shbg

SHBG is talked about a lot as a good predictor of how fast one clears testosterone out of their body. Low SHBG frequently necessitates the need for more frequent injections per week. Do factors such as EGFR and hypothyroidism also factor into how fast an individual processes testosterone? On the...

I'm a little confused as to what low SHBG means in terms of dosage. I've seen multiple posts say one of two things 1) Low SHBG means that a lower dosage (<125mg/week) is most likely necessary due to high Free T/ Free E 2) Low SHBG means that a higher dosage (>150mg/week) is necessary because...

Hi all, First time poster. I'm hoping to get some thoughts on my recent blood tests asap as I have an appointment with my doc tomorrow morning so want to be informed and prepared. Blood test results are attached in photos. I've been on trt 6 weeks, had the bloods done on Monday before HCG, T...

The all knowing FDA does not approve of human use. You cannot have it prescribed. I have crazy high SHBG that was stealing most of my free T even on heavy handed TRT. You'll have to do your own homework to find a source that is reliable.

Hi guys my SHBG is consistently in the upper part of the range (e.g. last test: 45.8 nmol/l with a range of 14.5-48.4). What would be a recommended injection frequency? Thx

Hello everyone. I was thinking about how testosterone levels are lower among all age groups for reasons that are difficult to explain and it got me to thinking about shbg. Are shbg values skewed high or low for unknown reasons because the top or bottom of the range can be problematic for some...

Hi everyone, I'm 32 years old and have secondary hypogonadism (was diagnosed at 25 years old). I've been on clomid for around 7 years now that was prescribed by my urologist. My main question is whether testosterone injections are more effective than clomid for secondary sexual characteristics...

My current protocol is injecting 50mg of testosterone every 4 days and 150IU of HCG every 4 days, no AI.. My last blood test came back as follows: TT 764, Free test 14, Estradiol 43, SHBG 46... My issue is that the 1st 2 days after the test injection, I kind of feel like crap. Tired, bags under...

SHBG, low testosterone, and type 2 diabetes. It's frequently said that a low SHBG value is a marker for type 2 diabetes - is that really the case? An Australian study examined prospective associations of SHBG and sex steroid levels in a cohort of community dwelling-men (ages ranging from 35-80)...

Dear forum, My wife is on the way to optimize her hormone levels after long period of inaccurate Levythyroxin medication and the possible damage it did (it went on for few years before she learned about the topic and found a doc that would prescribe Armour). Looking for expert thoughts on the...

Many times the articles, more specifically, the research articles we read relating to all the various components of TRT are not written for the layman to understand. Therefore, I believe a lot of us, myself included, stop reading because trying to self-educate ourselves can be a difficult...

Hi, Age: 44 Physics: slim, muscular, physically active (workout 4-5 times/week). Diet: very healthy Alcohol consumption: normal. 11/6-18: I got blood work done due to depression, fatigue, loss of sex drive, ... [see test/20171116]. 04/01-18 started Testogel. Gels both had an effect on the...

My recent experience with boron. I did blood tests on 1/5/2018, 2/20/2018 and 4/21/2018. The only thing I changed was taking the boron supplement late February. The first month I mixed up my own boron from 20 mule team borax, so I was probably taking 7-10 mg daily, since I would take a...

I read that thyroid meds can increase SHBG. Questions: 1. I have not found definitive info if it is the T4 in the meds or the T3 or both that cause this effect? 2. Is there any info on dose-response of Thryoid on SHBG? I'm being treated for hypogonadism (Cypionate 200mg/weekly +...

I'm 42 yrs old and the last 4 years my energy, strength, and stamina have plummeted. I am generally an athletic/slender guy but my midsection has increased a lot, and I have become very sluggish. My sex drive isn't great so I thought I might take a stab at this TRT stuff&#8230; Here is...

Hello guys. I need some guidance on possibly adjusting my protocol due to high SHBG. Here is my story, I have been on Test Cyp for about 4 months and it has worked very well for me. Started with a low dose of 100mg per week injecting E3.5D, no AI, no HCG. Two months later, on my follow up lab, I...

Hello all and thank you in advance. Little bit of history, I'm a 42yo male, 6'1”, 193lbs and 13% BF. Workout with heavy weights 5 times a week and cardio once per week. I'm on my 6th week of TRT recommended by my doctor for low energy and low libido, poor erections. The doctor found issues with...

Hi everyone, i have too high SHBG. Have you got any ideas how should i deal with it? For last month i was taking 10 000 vit D per day, but felt no changes so since week i take 20 000 vit D per day. Is there any difference if i take vit D once per day or should i take it 2-3 times per day? I...

Does any one have labs that show the SHGB increase after they started more frequent smaller injections? How much did numbers change? Did symptoms you were having dismiss and if so how long did it take for them to dissipate?

So I've done numerous blood tests with similar results. Here are my latest ones: E2: 0.12 (nmol/l) <0.15 [about 33 pg/ml] - Stupid range, but this is actually quite sensitive test Free T: 194 (pmol/l) 155-800 SHBG: 10 (nmol/l) 15-95 T: 8.5 (nmol/l) 8.0-29.0 [about 245 ng/d] These were...

Sex Hormone Binding Globulin levels play a critical role in the success or failure of a TRT protocol. Many men come to Excelmale never having had their SHBG levels checked. In some cases that may be a cost-saving measure, but in far more situations it's simply physician ignorance. Recently the...

I'm a lowish SHBG guy (~19 ref range 19.3-76.4) - started on gels with an endo with limited success and switched to Defy in April. Dr Saya's protocol is subq 44 mg of TestC + 300 IU of HCG 3x/week. Before starting BP normal ~120/83 hematocrit 47.5 (37.5-51.0) Hemoglobin 16.0 (12.6-17.7) PSA...

Have found some information while browsing on this SERM. One of the negative side effects most commonly brought up is that it raises SHBG. However, for those that have low SHBG such as myself..... wondering if this could this be of benefit ? Other benefits are listed as reversing/preventing...

I'm 41 and started TRT Novemeber 2016. Currently on Test. Cyp. (IM) and HCG (SQ) every other day and 25 mg DHEA twice daily (From Defy). I have an appointment in July. Just had blood work and have some questions. Here are the highlights. T total = 932 (up from ~200 pre-TRT, feeling...

Please advise. Just finished first round of Bio T pellets and about to switch to T gel (20%) next week to get a steady consistent dose. My dilemma is my high SHBG levels. Total T: 646 SHBG: 77.4 Free T: 7.6 Two part question. Will lowering SHBG level increase Free T, and is there a...

I have been on TRT for almost one year now and I am trying to keep my Total Testosterone around 1100-1150 ng/dl. Protocol and bloodwork results below: Testosterone cypionate 200mg/ml 0.35ml 2x a week. HCG 400IU 2x week TT 1331 ng/dl FT 35.6 pg/ml SHBG 25.3 nmol/L Testosterone cypionate...

SHBG is mentioned a LOT on this forum, and often many men are unhappy with their levels. Very few comments regarding SHBG are positive in nature, in fact SHBG is seen as a problem by many, and in the steroid community it is seen as something that needs to be lowered otherwise it'll "steal" all...

Hello, I've had libido and erection issues off and on for at least five years. During the same time frame I've also experienced periods of melancholy mood. I have a bit of anxiety but I've not needed medication. My sex drive and erection quality have both taken a huge dive over the past 12...

Hello guys, I've been on TRT for about a year now. After a lot of trial and error I found a protoclo that works for me and it's 140 mg Test E split into 2 doses 1.25 mg arimidex per week This puts me at around 1.000 ng/dl and keeps my e2 low. Now my SHGB is 21 which falls into the normal range...

Hey guys I have low Shbg 15-18nmol/l pre-trt I wonder if low shbg should stick to a lower trt dose? Like 80-100mg/week, if I'm correct low SHBG Leads to easier elevated estrogen? As I feel some lump and strings under my chest mass if I grab hard and feel I am currently on 150mg/week split on...

Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans Andreas Peter1, Konstantinos Kantartzis1, Jürgen Machann2, Fritz Schick2, Harald Staiger1, Fausto Machicao1, Erwin Schleicher1, Andreas Fritsche1, Hans-Ulrich Häring1 and Norbert Stefan1 1Department of...