shbg

My TRT SHBG is 16 which is kinda low. I've read TRT lowers SHBG, but by how much? Is is possible my natural SHBG is around 16? I don't have bloodwork that measured SHBG pre TRT

For those of us with average T levels and/or higher SHBG, our bodies are producing enough T, they just aren't using what's there because it is being bound by SHBG and isn't bioavailable. Why hasn't the pharmaceutical industry focused on producing medications that control (increase/decrease)...

My question might be a basic one, but what is the purpose of Sex Hormone Binding Globulin (SHBG)? In general terms I appreciate that SHBG binds to Total Testosterone (along with Albumin) to give us Free Testosteron. My question is not about what “normal values” of SHBG might be, it is more...

Hi there, I'm 44 now and 6yrs ago I was diagnosed with Type1-Diabetes. I changed my way of life then, lost about 30kgs, started with sports. My diet changed from typical western high-carb diet to a primal eating habit. No grains, sugar, rice. Mainly meats, eggs, dairy, some legumes, seeds,nuts...

How long does it take SHBG to change if, for example, it has been lowered through the use of say high dose testosterone or the use of oxandrolone? If one were to lower the dose of testosterone or cease using oxandrolone, when could one expect to see a rise in SHBG in lab work? We’ll assume...

I can't find the pubmed study at the moment, but it's all over Google if searched. Apparently, fish oil lowers SHBG. I'm wondering how drastic this effect could be and if cutting my EPA/DHA dose from 2.4g to 1.2g may let it rise. I've read on here that guys with low SHBG have harder times...

Hello all, I have seen this idea thrown around on trt and steroids forums that low SHBG causes high free E2 and that the use of DHT derivatives like Proviron, Anavar can cause gyno by lowering shbg = > high free Test => more aromatization. But as per this study SHBG preferentially binds to DHT...

so due to low T for a long time i sadly got into drinking alcohol for like 5 months now, daily (except a week and some days off here and there) around 12 beers a day. obviously that needs to stop and im already trying to reduce and then stop alcohol completely. so, ive heard that alcohols...

So I don’t want the medical technical Mumbo jumbo about it’s a carrier protein and all but what I want to know is if someone has low shbg what do they feel like . Should they feel tired , not optimized , workouts suck ,low sex drive, recovery ect . Does having normal levels make you feel better ?

I have a weird question I do t know if I'm going to be able to word it right. But I'm curious why free testosterone is so import if shbg transports androgens to the cellular targets. This paragraph is from a study on pub med. I can be completely off on my interpretation. classical hormones...

It doesn't make sense to me, but I am sure there's something I'm missing. Note, I know that there is a complex relationship here, but I'm looking at this on the surface level. Isn't the "low SHBG = more frequent injection at a lower dose" protocol a bit counterintuitive? For example. Let's...

Maybe someone here can advise me on where and how to proceed next. Perhaps there is some obscure hormone level or something else that the doctors have neglected to test for that would unlock the mystery of my condition. I am in despair that I will ever get an answer, much less any treatment. I...

Any guys here with normal total t and high shbg (pre trt) that could give me some advice please? Had blood tests done 4 time over the last year. Each time everything was right where it needed to be axcpet for my shbg. Total t has been 620-743. Shbg has been 56-75. Putting my free t between 9.1...

If there is some ideal T/E2 ratio, what role does SHBG have there? I have extremely low SHBG, so should I reduce or increase ratio, because of different binding affinity.

Long-term TRT patient, current protocol is 154mg/week in EOD SubQ shots (into thigh, belly, hip, etc). I've struggled on and off with digestion issues (constipation) and lack of deep sleep. A few months ago I started intermittent fasting and it's been good for dropping some weight. That combined...

Over the past decade, there have been important breakthroughs in our understanding of the regulation and function of sex hormone-binding globulin (SHBG). A recent genome-wide association and Mendelian randomization study have provided new insights at the population level. A thorough study of...

Hey guys, It seems like this has been a great method to increase libido for many of the members and in particular DHT levels. For those where it has worked when you have introduced cream with normal injections is there a protocol that you found worked best or a cream dosage that was sufficient...

I've tried to see effects of enclomiphene on SHBG levels. Seen a study but lost the link for it. I think it was a study done as part of FDA approval. I've also seen a few different people posting before and after blood test results in a few different forums. It's starting to seem that maybe if...

My current protocol is 30mg Test Cyp eod. Before trt, my shbg was in the 80s n/mol. With every blood test over the past year it has gotten progressively lower 45 n/mol, 35, and now my most recent is 29. Im getting concerned that it might get TOO low (sub 20). Anyone have experience with this...

What's up guys. I'm wondering how many low shbg guys use an a.i. I've never felt 100% dialed in on trt and have been at this on and off for over 10 years. I feel decent on 90mg of test e a week split mwf. I've tried many different frequency and doses and this has me feeling ok with tt of 500...

I have been on TRT for about three years. In January I switched to daily injections in an effort to control hematocrit, acne and sleep issues. I began at 20 mg per day and have slowly decreased my dose down to what is now 14 mg per day under the theory that the lowest possible dose is best. I...

Hey guys, I am going to be trying NDT in the near future to increase my low thyroid numbers and am hoping a side effect may be increased SHBG from what other members have experienced. That said my TT is 1100, FT 29 and DHT 60. Right now my SHBG sits around 16. Say it increases to 30 what kind...

Is 25 nmol litre considered low?

New to the forum and very new to trt (only 10 days in). I've had 4 tests pre trt over 18m and all with shbg with following results: 23 (latest and lowest) , 26, 31, 34 nmol/L. Should I be worried about having low shbg? Currently my protocol is e5d 125mg Sustanon. Do I need to move to EoD or...

Hi everyone ,I « heard »different thought about the effect of injection frequency on shbg For the same dose ,let’s say 200 mg. Injecting everyday instead of once a week for example will it increase or decrease shbg?

I’m currently injecting 80mg once a week but I’m increasing my dose to 100mg. My current SHBG is 23 but I’m concerned this increase will lower it? What do you guys think?

Hey guys, I recently began supplementing with a low dosage of micronized DHEA(10mg daily) to see if I can boost my lower levels. I ran 25mg a day at one point in the past with a cheap version and it caused some estrogen related side effects which I was trying to avoid with a better quality...

Thanks for taking the time. This is a follow up to my thread from last week (Total T > 1000 ng/dl (very high), Free T < 65 pg/ml (very low)). Total and Free same deal as last time, and not surprisingly SHBG is super high. Is there anything else in there I should pay attention to? I'm 40yo, in...

VA didn't have a Dr for me at local clinic, result I got a bunch of test done! I was really struggling with a T dose of 200mg split daily and in anticipation of new bloods I lowered dose to 150mg a week for one week and then to 140mg a week, a game I have to play so VA wont cut my dose. However...

Hey TRT fellows, I’m still struggling to get the best out of my trt journey and have a question that I can’t seem to find a definitive answer for: Is a SHBG of 24.2 nmol/L considered low ? And Would u go with an ED or EOD protocol with a SHBG level similar to mine ? Thank you

Has anyone been successful in decreasing SHBG level by using boron supplement without TRT?if YES, please give details