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![Nelson Vergel of ExcelMale.com and DiscountedLabs.com discusses two crucial studies concerning testosterone's impact on the cardiovascular system. The studies are:
The Traverse Study:
Published recently.
The Endocrine Society concluded that men using testosterone replacement do not have an increased risk for cardiovascular events.
This counters some prior studies which suggested the opposite.
There were signals of non-fatal arrhythmias needing intervention in the testosterone group.
The ToM Trial:
Conducted from 2008-2010.
Involved 209 elderly men with low testosterone levels.
The primary goal was to see if testosterone treatment increased their strength.
The trial was halted due to cardiovascular events being more common in the testosterone group than the placebo group.
Nelson highlights his concerns with these studies. He notes the following:
Older men with hypertension or afib taking testosterone might need closer monitoring.
There's an unexplored potential link between increased hematocrit (blood viscosity) due to testosterone replacement and cardiovascular events.
He raises the question if the observed non-fatal cardiovascular events in these studies could be due to the neurological stimulatory effects or the increase in blood viscosity caused by testosterone replacement therapy.
Lastly, Nelson also emphasizes the need for studies comparing testosterone injections with gels and creams.
Heart palpitations and AFIB (Atrial Fibrillation) risk in older men using testosterone is examined in the context of two studies: TOM and TRAVERSE.
Highlights
[⚠️] Testosterone use in older men and its link to heart palpitations and AFIB.
[💡] Research findings suggesting a potential association between testosterone therapy and heart rhythm disturbances.
[📋] Discussion about the need for cautious testosterone administration in older male patients.
[⚙️] Insights into the mechanisms through which testosterone might impact heart health.
[🔍] Examination of existing studies to assess the credibility of the testosterone-heart health connection.
[🩺] Importance of monitoring heart health during testosterone treatment for older men.
Remaining Questions About Testosterone and Cardiovascular Events
Would testosterone injections have a more significant negative effect on hypertension and arrythmias in older men than testosterone gels/creams?
What is the role of increased hematocrit in fatal and non-fatal cardiovascular events?
Should older men with hypertension or AFIB given testosterone be monitored more closely?
Is the observed increased incidence of non-fatal cardiovascular events in the two T-gel studies (TOM & TRAVERSE) caused by stimulatory, neurological, or increased blood viscosity effects of TRT?
DEFINITIONS OF TERMS:
Cardiac syncope: This can occur due to an underlying heart condition, such as an arrhythmia or structural heart problem, which disrupts the normal pumping of blood to the brain
Atrial fibrillation (AFIB) is an irregular and often very rapid heart rhythm, also known as an arrhythmia[1][2][3][4][5][6]. During AFIB, the heart's upper chambers (the atria) beat chaotically and irregularly, out of sync with the lower chambers (the ventricles) of the heart[1][2][3][4][5][6]. This can lead to blood clots in the heart, which can be extremely dangerous if they travel to the brain and cause a stroke[2][3][5]. Some people with AFIB may have no symptoms, while others may experience a fast, pounding heartbeat (palpitations), shortness of breath, weakness, lightheadedness, extreme fatigue, chest pain, or other symptoms[1][2][4][5]. AFIB can increase the risk of stroke, heart failure, and other heart-related complications[1][2][3][4][5][6]. The risk for AFIB increases with age, high blood pressure, heart disease, obesity, diabetes, and other factors[5]. AFIB can be diagnosed through a physical exam, including a check of the heart rate and rhythm, and an electrocardiogram (ECG or EKG) [3]. Treatment for AFIB may include medications, therapy to reset the heart, and other interventions[1][2][4][5][6].
Citations:
[1] https://www.mayoclinic.org/diseases-conditions/atrial-fibrillation/symptoms-causes/syc-20350624
[2] https://www.heart.org/en/health-topics/atrial-fibrillation/what-is-atrial-fibrillation-afib-or-af
[3] https://www.hopkinsmedicine.org/health/conditions-and-diseases/atrial-fibrillation
[4] https://my.clevelandclinic.org/health/diseases/16765-atrial-fibrillation-afib
[5] https://www.cdc.gov/heartdisease/atrial_fibrillation.htm
[6] https://www.nhlbi.nih.gov/health/atrial-fibrillation
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