Retatrutide entered 2026 with impressive Phase 2 data. Five positive Phase 3 studies have since changed the discussion.
The strongest obesity trial reported 70.3 pounds of average weight loss with 12 mg over 80 weeks. A two-year extension involving people who started with a BMI of at least 35 reported an average loss of 85 pounds.
Those numbers deserve attention. They also need context because higher doses produced more gastrointestinal symptoms, dysesthesia, and treatment discontinuation...
Featured content
GLP-1 medications such as Ozempic, Wegovy, Mounjaro, and Zepbound have transformed weight-loss treatment. Yet the scale tells only part of the story.
Rapid weight loss often includes lean mass. Losing muscle affects your strength, metabolism, mobility, appearance, bone health, and ability to maintain your results.
Lose Fat, Not Muscle gives women and men a practical plan for reducing body fat while preserving strength, function, and long-term health.
Inside this book, you will learn...
For years the same question has come up on this forum in a hundred different forms: the pills stopped working, now what?
I finally wrote the full answer down. My new book, From Pills to Implants: The Honest Guide to Every Erectile Dysfunction Treatment, comes out soon.
It walks through every ED treatment that actually exists, in order, from first-line pills to injections, vacuum devices, hormones, PT-141, shockwave, and implants. For each one it grades the evidence honestly and names the...
Thread title (enter separately in XenForo): What Testosterone Level Do You Need to Protect Muscle After 50?
By Nelson Vergel | B.S. Chemical Engineering, MBA | Founder, ExcelMale.com | 34+ years on TRT | NIH and FDA advisory panel service | Author: Testosterone: A Man's Guide, Beyond Testosterone, The Peptide Consensus
Updated July 2026
Total testosterone in the 1,001 men studied was 400 ng/dL in the 40s and 403 ng/dL in the 50s. Statistically the same number. Grip strength was not...
HOW TO PREVENT PRIAPISM CAUSED BY TRIMIX
What is priapism:
Priapism is an erection which lasts more than 4 hours and is unrelieved by ejaculation. This condition is a true urological emergency and early treatment allows the best chance for functional recovery. Failure to manage this issue can result in penile fibrosis that may increase the risk of curvatures or impaired penile blood flow that may lead to erectile dysfunction.
How to prevent priapism when using Tri-Mix or other penile...
Could microdosing PT-141 (bremelanotide) deliver better libido results than standard doses? Many men find that typical PT-141 doses (500mcg-2mg) produce disappointing or inconsistent effects on libido—but a different dosing strategy involving multiple small daily doses may unlock dramatically better results by better mimicking natural α-MSH physiology.
This detailed discussion documents a protocol using 15-20mcg of bremelanotide injected 5 times throughout the day, which produced high...
New to retatrutide? This beginner guide covers starting doses, how to titrate, safely, what results to expect, and how to avoid common side effects.
Looking for the full protocol? See the complete dosing, results & side-effects guide.
Curated By Nelson Vergel | ExcelMale.com | Updated March 2026
Key Takeaways
Retatrutide is a first-in-class triple hormone receptor agonist (GLP-1 + GIP + glucagon) from Eli Lilly, currently in Phase 3 clinical trials under the TRIUMPH program.
In...
HRT in Women — Master Index
Comprehensive guide to hormone replacement therapy resources for women, including testosterone therapy, menopause management, sexual health, and clinical guidelines. Last updated: February 2026
▶ GETTING STARTED
Hormone Replacement Therapy HRT for Women Guide ⭐ Start Here (3K views)
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Practical Clinical Summary on Testosterone Therapy in Women (196 views)
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Nutrition & Supplements — Master Index
Your guide to nutrition, supplements, and dietary strategies for optimal health. Last updated: February 2026
▶ GETTING STARTED
Clean Nutrition for Health, Muscle Gain and Fat Loss ⭐ Start Here (22K views)
Best Vitamins and Supplements by Nelson Vergel (15K views)
Collection Of 250+ Studies: Supplements, Vitamins, Bioavailability, Micronutrients (6K views)
▶ NITRIC OXIDE & CARDIOVASCULAR SUPPORT
Gene's Nitric Oxide Stack ⭐ (662K views)
NO: The...
How-To Guides & Calculators — Master Index
Dosing calculators, injection guides, lab test resources, and reference materials. Last updated: February 2026
▶ CALCULATORS & TOOLS
Free Hormone Calculator Suite ⭐ Start Here — TRT, hCG, E2/DHT prediction
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Your complete guide to understanding and ordering lab tests for TRT monitoring. Last updated: February 2026
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Welcome to the HCG, Clomid & Fertility Forum!
This index organizes our best resources to help you find what you need quickly. Whether you're preserving fertility on TRT, considering Clomid therapy, or planning PCT, start here.
▶ FERTILITY PRESERVATION & TRT
Fertility Preservation on TRT: The Complete Guide ⭐ Start Here
hCG Plus TRT Testicular & Fertility Restoration Protocol
Semen Analysis and Freezing Sperm Prior to TRT
Success Story: Fertility Restored While on TRT with hCG
Fertility...
TRT Resources Hub
Your Complete Guide to Testosterone Replacement Therapy
Welcome to ExcelMale's TRT Resources Hub!
This thread consolidates our best educational content into one easy-to-navigate guide. Whether you're just starting to research TRT or you're optimizing an existing protocol, you'll find organized, evidence-based information here.
How to use this guide:
• Scroll to find your topic of interest
• Click any link to open the detailed discussion thread
• Bookmark this page for...
tldr; absolutely the best weight loss peptide IMHO to date
I want to summarize my early exp. with retatrutide. I could not handle any semaglutide in the past, even 0.1mg gave me hellish nausea and lethargy. but R. is different.
- 2 weeks ago I started a protocol, 2mg/week, divided in 2 injections.
- absolutely no nausea or lethargy, if anything a good energy boost
- significant appetite reduction, but you can still eat, to give you an example, my typical lunch would be normally 400g ground...
What if one molecule controls your blood flow, oxygen delivery, metabolism, immunity, sexual function, and cognitive performance — and most people are critically deficient in it? In this episode of Metabolic Matters, Dr. Nasha Winters sits down with Dr. Nathan Bryan, one of the world’s leading experts in nitric oxide biochemistry and a pioneer whose discoveries have reshaped cardiovascular and metabolic health.
With 20+ years of groundbreaking research, dozens of patents, multiple biotech...
Porn Addiction- Diagnostic Landscape and Controversy
The clinical status of problematic pornography use remains contested. Compulsive Sexual Behavior Disorder (CSBD) is recognized by the WHO in the ICD-11 as an impulse control disorder, but the DSM-5 does not recognize it as a standalone diagnosis. Wikipedia CSBD is characterized by a persistent pattern of failure to control intense, repetitive sexual impulses or urges, resulting in repetitive sexual behavior over an extended period (six...
This review investigates the use of the synthetic steroid oxandrolone across various clinical populations. The review analyzes twenty-four randomized controlled trials to synthesize evidence regarding the safety and effectiveness of oxandrolone for conditions such as severe burns, HIV-associated weight loss, Turner syndrome, and Klinefelter syndrome. Overall, the findings suggest that oxandrolone is associated with improvements in body composition indices and reduced hospitalization time...
PARTICIPATION NEEDED!
Of those EM members that have taken nandrolone or are currently taking nandrolone alongside their TRT, we are conducting a small ExcelMale study to help determine the effect that nandrolone has on Total Testosterone, E2, Prolactin, SHBG, free T, and DHT while taking TRT.
Here is what is needed:
Simply post the following information...
(1) Pretest Labs (Labs taken before adding nandrolone to TRT):
TT
Free T
SHBG
E2
Prolactin
DHT
Blood Assay Methodology
RX Protocol...
Thread 'Nandrolone Use in Testosterone Replacement Therapy: Insights from ExcelMale.com Discussions'
Comprehensive Analysis of Nandrolone Use in Testosterone Replacement Therapy: Insights from ExcelMale.com Discussions
Nandrolone, a synthetic anabolic-androgenic steroid, has garnered significant attention within the ExcelMale.com community as an adjunct to testosterone replacement therapy (TRT). This report synthesizes evidence from forum discussions, clinical studies, and expert insights to explore nandrolone's therapeutic benefits, dosing protocols, physiological mechanisms, and...
Is Clomid (clomiphene citrate) a good alternative to TRT for men with low testosterone? Clomiphene can raise testosterone levels while preserving fertility—making it attractive for younger men who want to avoid testicular shutdown. But new research suggests we should be monitoring IGF-1 levels in all patients on clomiphene therapy.
This thread discusses the latest clinical findings on clomiphene's effects on IGF-1, growth hormone pathways, and what this means for long-term safety. We'll...
I hope you enjoy this part 1. Yes, it is almost 2 hours long but I concentrated everything I know so that you do not have to read for hours.
What is low testosterone (hypogonadism) and how is it diagnosed?
Low testosterone, or hypogonadism, refers to insufficient testosterone levels in men, which can impact various bodily functions. It's broadly defined by total testosterone levels ranging from 300-350 ng/dL (nanograms per deciliter) to 1100 ng/dL, with some experts considering levels...
ExcelMale.com Quick TRT Guide:
DIAGNOSIS OF HYPOGONADISM:
Symptoms and signs suggestive of testosterone deficiency in men:
A. More specific symptoms and signs
• Incomplete or delayed sexual development, eunuchoidism
• Reduced sexual desire (libido) and activity
• Decreased spontaneous erections during sleep
• Breast discomfort, gynecomastia
• Loss of body (axillary and pubic) hair, reduced shaving
• Very small (especially <5 ml) or shrinking testes
• Inability to father children, low...
