Hormones

FDA Expert Panel on Menopause and HRT Recommends Removing Black Box Labels

Jul 19

This was a very important meeting with top experts that are trying to change guidelines. This FDA panel recently recommended removing the warning (“black box”) labels on menopausal HRT, citing potential benefits like reduced heart attack and bone...

Heart Health Hormones HRT in Women Women's Health

How Compounding Pharmacies Are Challenging Big Pharma on Fair Access

Jul 08

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13-Minute Podcast: This podcast discussion examines the burgeoning role of compounding pharmacies, particularly in the context of GLP-1 medications, and how they are challenging the established dominance of Big Pharma. Driven by soaring drug...

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Deca Gains. What to expect

Jun 26

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Doc just prescribed me 100mg weekly of Deca for joint pain and a bad shoulder. my current protocol is Test Cyp 180mg weekly (pin eod). I am a seasoned lifter. 38 years old. about 12% bf. Pull 500 pound deadlifts for reps. Since starting TRT...

Anabolic Agents Health & Wellness Hormones Men's Health Muscle Gain

Testosterone Replacement Therapy (TRT) Facts Every Man Should Know

Jun 23

Testosterone Replacement Therapy (TRT) can be life-changing for many men suffering with low testosterone symptoms. However, there are crucial facts that most men are not told by their physicians before they start TRT. Here are the top facts that...

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Pregnenolone in Men: Help determining proper dosage and frequency

Jun 21

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Hi all, I've been experimenting with pregnenolone for over a year now, with varied success. I seem to get benefits at 100mg (such as higher libido, more pronounced nighttime erections and better sleep); however, I don't get these results...

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What it the purpose of Sex Hormone Binding Globulin (SHBG) ?

Jun 17

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My question might be a basic one, but what is the purpose of Sex Hormone Binding Globulin (SHBG)? In general terms I appreciate that SHBG binds to Total Testosterone (along with Albumin) to give us Free Testosteron. My question is not about...

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Best HCG Dose for Men on TRT: Two Studies That Used HCG with Testosterone

Jun 15

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Note:HCG mimics LH but it is not LH and it's not picked up by the LH blood test. In fact, it suppresses LH like endogeneous testosterone does. But the amazing thing that the study below found is that HCG can increase sperm production and quality...

Erectile Dysfunction Fertility HCG Hormones Men's Health Sex drive Sperm count Testicular Atrophy Testosterone Testosterone side effects TRT

Diagrams: Accurate Androgen and Estrogen Measurement in Human Serum and Plasma

Jun 06

* Probably the most challenging forms to quantify, due to their relatively low concentrations are the so called free forms. The free forms of all the hormones (shown in Figs. 1–3) are the hormones not bound to proteins, or conjugated to other...

Blood Tests Hormones TRT blood tests

Testosterone blood level is correlated with immune cell abundance in transgender young people on gender affirming hormones

Jun 03

Sex hormones like estrogen and testosterone don’t just affect things like body shape or voice—they also play a role in how the immune system works. This is especially important for transgender people who take these hormones as part of their...

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Estradiol: The "Other" Male Hormone

May 31

Download slides (from my book "Beyond Testosterone"): Estradiol in Men Slides Estradiol in Men: The Stigma In the 2014 film The Other Woman, Cameron Diaz, Leslie Mann, and Kate Upton, portray three jilted females who discover they are...

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Clomid (Clomiphene) Reduces IGF-1, a measure of Growth Hormone

May 27

Summary of Study Findings: "Reduced IGF-1 Levels Following Clomiphene Treatment for Male Hypogonadism" (Journal of the Endocrine Society, 2025) Objective: To investigate whether clomiphene citrate—a selective estrogen receptor modulator used...

Clomid (Clomiphene & Enclomiphene) Hormones Men's Health Muscle Gain

Oxandrolone (Anavar) : The Most Studied Oral Anabolic Agent in Wasting and Catabolic Conditions

May 20

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Oxandrolone is a man-made anabolic androgenic agent that has been studied by doctors for more than 30 years, mostly because it might help treat catabolic disorders and chronic wasting conditions like alcoholic hepatitis, severe burn injuries...

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038