Hormones

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Testosterone and LH Levels Are Falling in Healthy Men: New Evidence of a Global Reset in Male Hormone Health
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Meta-regression analysis, using testosterone serum levels as effect of the regression, the years of sample collection as covariates and subjects’ number, age and BMI as co-factors (BMI was available for 742 study groups). Statistical details are...
Comprehensive Analysis of Testosterone Carrier Oils: Formulations, Clinical Implications, and Emerging Developments
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The selection of carrier oils in testosterone formulations represents a critical yet underappreciated aspect of hormone replacement therapy. This report synthesizes data from pharmaceutical manufacturers, clinical reports, and patient experiences...
A Deep Dive into Growth Hormone Secretagogues (Peptides): Clinical Evidence, Mechanisms, and Therapeutic Applications
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A Deep Dive into Growth Hormone Secretagogues: Clinical Evidence, Mechanisms, and Therapeutic Applications Growth hormone secretagogues represent a revolutionary approach to enhancing human growth hormone production through targeted stimulation...
Testosterone clinics - Do they know what they are doing?
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* They discuss how these clinics often bypass proper lab testing, ignore fertility risks, and prioritize quick prescriptions over patient safety—all under the buzzword of “optimization.” Testosterone therapy is trending—but are clinics...
427-Page Illustrated Book: Beyond Testosterone
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I am very pleased to announce that I finally finished my full color 427-page booK: Nelson Vergel's "Beyond Testosterone: The Illustrated Guide" and the associated free online resource at Excelmale.com serve as comprehensive guides to...
What Really Happened at the FDA Menopause Panel
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The FDA finally held a hearing on menopause—and it was long overdue. Georgie Kovacs breaks down the powerful expert testimony, the systemic failures, and why this matters for every woman navigating midlife care. In this grounded recap, you’ll...
FDA Expert Panel on Menopause and HRT Recommends Removing Black Box Labels
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This was a very important meeting with top experts that are trying to change guidelines. This FDA panel recently recommended removing the warning (“black box”) labels on menopausal HRT, citing potential benefits like reduced heart attack and bone...
How Compounding Pharmacies Are Challenging Big Pharma on Fair Access
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13-Minute Podcast: This podcast discussion examines the burgeoning role of compounding pharmacies, particularly in the context of GLP-1 medications, and how they are challenging the established dominance of Big Pharma. Driven by soaring drug...
Deca Gains. What to expect
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Doc just prescribed me 100mg weekly of Deca for joint pain and a bad shoulder. my current protocol is Test Cyp 180mg weekly (pin eod). I am a seasoned lifter. 38 years old. about 12% bf. Pull 500 pound deadlifts for reps. Since starting TRT...
Testosterone Replacement Therapy (TRT) Facts Every Man Should Know
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Testosterone Replacement Therapy (TRT) can be life-changing for many men suffering with low testosterone symptoms. However, there are crucial facts that most men are not told by their physicians before they start TRT. Here are the top facts that...
Pregnenolone in Men: Help determining proper dosage and frequency
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Wondering what pregnenolone dose and frequency works best for optimizing your hormone balance on TRT? Pregnenolone, the "mother hormone" that serves as a precursor to numerous steroid hormones, requires careful dosing consideration due to its 3-4...

What it the purpose of Sex Hormone Binding Globulin (SHBG) ?

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My question might be a basic one, but what is the purpose of Sex Hormone Binding Globulin (SHBG)? In general terms I appreciate that SHBG binds to Total Testosterone (along with Albumin) to give us Free Testosteron. My question is not about...

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