Off-Label Use of Bremelanotide (PT-141) in Men: Insights on Libido, Erections, and Safety from Experts

[madman]

In this episode, Dr. Brandon & Dr. Morgentaler talk about the off-label use of bremelanotide (Vyleesi/PT-141) in men—its potential benefits for libido/erections, origins, side effects (notably nausea), and how patients often access it via compounding pharmacies.




Chapters

00:05 – Dr. Brandon & Dr. Morgentaler dive into Bremelanotide and share how the Goldsteins have been pioneering its research.
02:08 – They laugh about the iconic Katz’s Deli “When Harry Met Sally” scene and its connection to sexual medicine history.
03:06 – The doctors explain how Bremelanotide works, how it’s used by both women and men, and why refills tell an important story.
08:43 – They tackle the criticism that women take these meds “for men,” pushing back and stressing women’s right to pleasure.
19:48 – Wrapping up, they encourage listeners to talk with their doctors or compounding pharmacies if they want to explore this option.

 

[madman]

Thread 'USE OF THE CNS AGENT BREMELANOTIDE IN MEN WITH SEXUAL DYSFUNCTION: RESULTS FROM A SEXUAL MEDICINE CLINIC'

Apr 19, 2024

USE OF THE CNS AGENT BREMELANOTIDE IN MEN WITH SEXUAL DYSFUNCTION: RESULTS FROM A SEWXUAL MEDICINE CLINIC
Sue W. Goldstein, Irwin Goldstein*, San Diego, CA


INTRODUCTION AND OBJECTIVE

Bremelanotide is FDA approved for premenopausal women with generalized, acquired hypoactive sexual desire disorder (HSDD). It modulates dopaminergic pathways involved in sexual desire and arousal in men and women and has been reported to increase genital blood flow within hours of subcutaneous administration. We have been prescribing bremelanotide off-label to men with sexual dysfunctions...

• madman
• bremelanotide; dopamine; sexual dysfunction
• Replies: 5
• Forum: When TRT Is Not Enough (ED, Libido, & More)

 

[madman]

Thread 'Treatments for Low Libido in Men'

Jan 25, 2022

The Potential for Pharmacological Interventions for Low Sex Drive in Men (2021)

Amit G. Reddy, MD,1 Amelia A. Khoei, BS,2 and Mohit Khera, MD1




NTRODUCTION

Despite numerous advancements in the field of sexual medicine, there remain a handful of conditions that are difficult to characterize, have poorly understood pathophysiology, and are challenging to treat. Of this subset of pathologies, a complaint of decreased libido or low sex drive (LSD) is one that is familiar to most sexual medicine providers. The reported prevalence of LSD in the male population...

• madman
• low libido; hssd
• Replies: 14
• Forum: When TRT Is Not Enough (ED, Libido, & More)

MELANOCORTINS

Melanocortins are another drug class with the potential to be pharmacologic treatment options for patients with HSDD. In 2019, the FDA approved the bremelanotide therapeutic (Vyleesi) for the treatment of HSDD in premenopausal women. Early evidence suggests that bremelanotide, an analog of the neuropeptide a-melanocyte-stimulating hormone, acts on a multitude of melanocortin receptors that are involved in excitatory pathways that have been implicated in sexual desire and arousal.14 Similar to flibanserin, bremelanotide’s mechanism of action in improving sexual desire has still not been fully elucidated and more pre-clinical data will be necessary to better characterize these neural pathways. In addition, even less information exists regarding bremelanotide’s safety and efficacy in improving low sex drive in male HSDD patients. However, bremelanotide has been shown in pre-clinical and clinical studies to improve erectile function in men through stimulation of centrally-acting melanocortin receptors located in the hypothalamus, and some data suggest that activation of this pathway also may trigger oxytocin release that may be implicated in sexual function.15,16 Future investigation into bremelanotide may provide more information regarding its role in the treatment of low libido in men.