Seeker of Wisdom
Incredible post! Very valuable experience you've gained and shared. Yes, I agree this deserves its own thread. I took my first 10 mg dose today and don't feel much of anything yet. So far so good I guess.Probably better for another thread specifically on MIF-1, I'll make one soon in the Mental Health forum.
But I've done multiple cycles of it and each one is kinda different. The 1st one I did back in May I didn't even feel anything until like the 4th day when suddenly while at an outdoor mall I could feel that "vibe" again. This peak effect subsided but I still felt like my baseline was higher for some time until crashing later on for unrelated reasons.
No side effects. Its an amazing peptide for me. When I first did it though I started the first day at a smaller dose like 5 mg just to make sure no adverse effects. One might think "Oh because PT141 improves libido then MIF1 will lower it" but this is absolutely not true and in fact its a little the opposite because if anhedonia improves, libido improves for me anyways and MIF is dopaminergic after all (But I wouldn't expect it to improve libido for a non-anhedonic/blunted person)
I was feeling horribly numb in late August, I had crashed badly and I was getting very worried and in a dark place. I took MIF-1 and then within 2 hours felt it this last cycle. Suddenly the world was brighter, I felt a huge motivation and hedonic tone boost, could anticipate the future again, feel the sun out. This peak effect went down but I still came out of the cycle "reset" back to a copable point. It has a great effect on lowering stress-too. And while on it, the morning dread of the day (when my symptoms are worst) gets so much better.
It seems like I feel the effects earlier with each cycle. Know that MIF-1 the effects can actually go backwards if you take too much too long (this is mentioned in a study on the oral form), which is why its important to keep the schedule/dosing in accordance with that study. The longest I've done it is 8 mg for 8 days and when I did it on the 8th day things kinda went backward slightly. 5-7 days at most seemed ok for me. 6 days for me is the sweet spot. I believe its because it inhibits alpha-MSH and some is needed.
I did do bloodwork on my alpha-MSH before and at the end of one of my cycles though and it didn't go down that much just from 13 to 9.
Also I think MIF-1 should be used like a 'reset' opportunity. So literally exercise intense every single day you are on a cycle of MIF to make use of that dopamine to try to make it stick. Another thing I found is taking Mucuna Pruriens L-dopa supplement synergises with it (this is also in studies, MIF potentiates L-dopa).
LDN I stop while on MIF to avoid any interactions with opiod system (MIF-1 is kind of like a super LDN, its an opiod antagonist in ways I don't really get) , but afterwards, I notice my LDN endorphin rebound is stronger too for like a few days.
These days Ketamine IV is presented as the 'hot' thing for anhedonia but MIF1 was way way better for me.