A different dosing strategy with bremelanotide (PT-141) yields dramatically better results

TL;DR: It may be possible to improve results with bremelanotide by taking multiple daily micro-doses.

Like many, I have experimented with bremelanotide at the recommended doses, which range from a few hundred micrograms up to a couple milligrams in one subcutaneous injection. And also like many, I found the results to be disappointing. Libido was not affected, spontaneous erections during the day were infrequent and random, and nighttime erections were prominent and disturbed sleep. Although the effects were not as desired, they seemed quite strong, leading me to question how bremelanotide compares to α-melanocyte-stimulating hormone, aka α-MSH, the hormone it augments. Some rudimentary calculations suggest that standard doses of bremelanotide could be comparable to an increase in α-MSH by as much as two orders of magnitude. That’s somewhat like giving a hypogonadal male 100 mg of testosterone propionate every couple weeks. He may experience some interesting effects, but there’s still some likelihood the overall experience would be poor, and certainly not comparable to TRT.

Credit to @Guided_by_Voices for also experimenting with and recommending lower doses of bremelanotide. I suspect these doses of 100-300 mcg could still be large relative to normal physiology — having very roughly estimated that multiple small daily doses on the order of 10 mcg would provide stimulation comparable to endogenous α-MSH. I set about testing this premise as follows:

Phase 1, days 1-4
Protocol: 20 mcg bremelanotide injected SC at 6 am, 9 am, 12 pm, 3 pm and 6 pm.
Results: Compared to a lackadaisical baseline, libido was high, even excessive and distracting. This began on the first day and continued for the entire phase. The “itch” was nearly constant, and erections came easily in response to sexual ideation or the presence of nubile females. This was again in marked contrast to baseline, where daytime erections were very uncommon without more substantial stimulation. The two negatives during this phase were a reduction in average sleep duration by 30-40 minutes and a slight feeling of overstimulation throughout. In fact these led to a dose reduction and the second phase. This was unfortunate from a data-gathering standpoint, because if the first phase was part of a honeymoon period then the period’s full duration was not established.

Phase 2, days 5-8
Protocol: 10 mcg bremelanotide injected SC at 6 am, 9 am, 12 pm, 3 pm and 6 pm.
Results: There was a rapid return to near-baseline conditions, though sleep still seemed degraded.

Phase 3, days 9-12
Protocol: 15 mcg bremelanotide injected SC at 6 am, 9 am, 12 pm, 3 pm and 6 pm.
Results: Libido improved a small amount. There was improvement in spontaneity of erections, but nothing like during the first phase. Sleep was modestly impaired compared to baseline.

Phase 4, days 13-15
Protocol: 20 mcg bremelanotide injected SC at 6 am, 9 am, 12 pm, 3 pm and 6 pm.
Results: This was an attempt to see if the results of the first phase would reappear after the prolonged exposure to slightly lower doses. They did not. Over these three days libido and sexual function dropped below baseline. Modest sleep impairment continued.

Phase 5, days 16-17
Protocol: no bremelanotide
Results: After this washout period things seemed to return to baseline.

Discussion: These results point to the need for further research. It’s intriguing to consider that it may be possible to obtain much better results with bremelanotide when it is dosed appropriately. While multiple daily injections are going to be unappealing to most, it seems likely that these protocols could be reproduced with correctly dosed troches and buccal delivery. It looks as though four days of the initial protocol was nearing the end of a possible honeymoon period, with most benefits dissipating soon thereafter. If so then the appropriate reset period is yet to be determined. If this period is only a week or two then the protocol is promising. My sense is that even 20 mcg taken five times a day is a pretty high level of stimulation relative to baseline α-MSH activity — thus caution is advised if long-term use is contemplated. It is concerning that prolonged continuous use in this trial seemed to degrade libido and sexual function below baseline, though at least recovery was rapid.

I continue to speculate that this is not the only case where overdosing a peptide obscures its full potential. For example, long-term micro-dosing of oxytocin may yield profound results that are dissimilar to what’s seen with occasional administration of much higher doses.
 
Probably better for another thread specifically on MIF-1, I'll make one soon in the Mental Health forum.

But I've done multiple cycles of it and each one is kinda different. The 1st one I did back in May I didn't even feel anything until like the 4th day when suddenly while at an outdoor mall I could feel that "vibe" again. This peak effect subsided but I still felt like my baseline was higher for some time until crashing later on for unrelated reasons.

No side effects. Its an amazing peptide for me. When I first did it though I started the first day at a smaller dose like 5 mg just to make sure no adverse effects. One might think "Oh because PT141 improves libido then MIF1 will lower it" but this is absolutely not true and in fact its a little the opposite because if anhedonia improves, libido improves for me anyways and MIF is dopaminergic after all (But I wouldn't expect it to improve libido for a non-anhedonic/blunted person)

I was feeling horribly numb in late August, I had crashed badly and I was getting very worried and in a dark place. I took MIF-1 and then within 2 hours felt it this last cycle. Suddenly the world was brighter, I felt a huge motivation and hedonic tone boost, could anticipate the future again, feel the sun out. This peak effect went down but I still came out of the cycle "reset" back to a copable point. It has a great effect on lowering stress-too. And while on it, the morning dread of the day (when my symptoms are worst) gets so much better.

It seems like I feel the effects earlier with each cycle. Know that MIF-1 the effects can actually go backwards if you take too much too long (this is mentioned in a study on the oral form), which is why its important to keep the schedule/dosing in accordance with that study. The longest I've done it is 8 mg for 8 days and when I did it on the 8th day things kinda went backward slightly. 5-7 days at most seemed ok for me. 6 days for me is the sweet spot. I believe its because it inhibits alpha-MSH and some is needed.

I did do bloodwork on my alpha-MSH before and at the end of one of my cycles though and it didn't go down that much just from 13 to 9.

Also I think MIF-1 should be used like a 'reset' opportunity. So literally exercise intense every single day you are on a cycle of MIF to make use of that dopamine to try to make it stick. Another thing I found is taking Mucuna Pruriens L-dopa supplement synergises with it (this is also in studies, MIF potentiates L-dopa).

LDN I stop while on MIF to avoid any interactions with opiod system (MIF-1 is kind of like a super LDN, its an opiod antagonist in ways I don't really get) , but afterwards, I notice my LDN endorphin rebound is stronger too for like a few days.

These days Ketamine IV is presented as the 'hot' thing for anhedonia but MIF1 was way way better for me.
Incredible post! Very valuable experience you've gained and shared. Yes, I agree this deserves its own thread. I took my first 10 mg dose today and don't feel much of anything yet. So far so good I guess.
 
I think PT-141 (bremelanotide) is quite dangerous, years back in 2018 it sent me into a severe anhedonia episode at 200 mcg. ...
The dose makes the poison. That 200 mcg could still be tenfold more potent than your endogenous α-MSH. You should also investigate whether milligram-level doses of MIF-1 are similarly excessive.

Now that I'm further from the daily dosing experiments I am finding that even a single 20 mcg dose of bremelanotide taken every third day has an effect on libido, albeit a modest one.
 
The dose makes the poison. That 200 mcg could still be tenfold more potent than your endogenous α-MSH. You should also investigate whether milligram-level doses of MIF-1 are similarly excessive.

Now that I'm further from the daily dosing experiments I am finding that even a single 20 mcg dose of bremelanotide taken every third day has an effect on libido, albeit a modest one.

Yea based on your analysis it probably was an issue, which is surprising given that 200 mcg is still within the lower end of what is typically dosed. My MC4 receptors must have still been hypersensitive

I do need do check what endogenous levels of MIF1 are. I know that when I tested alpha MSH on bloodwork before and after was 13 and 9.
 
The dose makes the poison. That 200 mcg could still be tenfold more potent than your endogenous α-MSH. You should also investigate whether milligram-level doses of MIF-1 are similarly excessive.

Now that I'm further from the daily dosing experiments I am finding that even a single 20 mcg dose of bremelanotide taken every third day has an effect on libido, albeit a modest one.
Since it's a modest one could it just be a placebo?
 
I can share my experience with pt141 1.5mg . Maximum consecutive daily use 2 days before tolerance develops. Minimum one week reset needed but even better one month. Perhaps some very mild anhedonia day 3and 4 after use but then rapid return to baseline mood. So for me it's a occasionally special treat use . Proerecttile but not prolibido for me. Btw I took a dose to sort out a booty call I wasn't that into tbh. All I can say is it's not that effective to do the job if you are doing a duty screw .
 
The dose makes the poison. That 200 mcg could still be tenfold more potent than your endogenous α-MSH. You should also investigate whether milligram-level doses of MIF-1 are similarly excessive.

Now that I'm further from the daily dosing experiments I am finding that even a single 20 mcg dose of bremelanotide taken every third day has an effect on libido, albeit a modest one.
Did you experience any of the anhedonia/blunting that is being discussed as possible side effect?
 
This is interesting so some men have a little sexual desire so they use bremelanotide to get their libido back. It makes me wonder what makes them to lose it in the first place. I would think it's anxiety. Maybe if you got rid of your anxiety your libido would stay strong?

This is a great thread and definitely some good information that may benefit us all
Capacious that's some testing and I think I amngoing to actually follow that for myself.
My problem is slightly different Vince you ask how fo some men lose libido I never lost it it was taken away when I had prostate surgery (nerve sparing robotic prostatectomy) for cancer. Cialis/viagra no real help but Bremelanotide (pt-141) filled a gap, I purchased and tried it from reputable peptide companies until I had my primary Dr write a prescription to a compound pharmacy and honestly that worked better, morning wood, arousal and erection more frequently. Bremelanotide (pt-141) bridged the gap.
Now to test myself with Caragious work

Stay tuned
 
This is a great thread and definitely some good information that may benefit us all
Capacious that's some testing and I think I amngoing to actually follow that for myself.
My problem is slightly different Vince you ask how fo some men lose libido I never lost it it was taken away when I had prostate surgery (nerve sparing robotic prostatectomy) for cancer. Cialis/viagra no real help but Bremelanotide (pt-141) filled a gap, I purchased and tried it from reputable peptide companies until I had my primary Dr write a prescription to a compound pharmacy and honestly that worked better, morning wood, arousal and erection more frequently. Bremelanotide (pt-141) bridged the gap.
Now to test myself with Caragious work

Stay tuned
I'm happy it's working for you and you have your love life back.
 
This is a great thread and definitely some good information that may benefit us all
Capacious that's some testing and I think I amngoing to actually follow that for myself.
My problem is slightly different Vince you ask how fo some men lose libido I never lost it it was taken away when I had prostate surgery (nerve sparing robotic prostatectomy) for cancer. Cialis/viagra no real help but Bremelanotide (pt-141) filled a gap, I purchased and tried it from reputable peptide companies until I had my primary Dr write a prescription to a compound pharmacy and honestly that worked better, morning wood, arousal and erection more frequently. Bremelanotide (pt-141) bridged the gap.
Now to test myself with Caragious work

Stay tuned
This is interesting. So after the surgery you lost erections AND libido?
Do you perhaps remember what drugs/meds (if any) you were given prior to surgery?
 
At my doctor appointment in September, he mentioned there is a new study out showing the positive effects of low daily dosing of PT141 versus the "on demand" high dose protocol. Similar benefits but much lower sides. I will see if I can get my hand on it and post here.

In the meantime, I had him call it in for me based on the lower dosing instructions. I will report back in due time.
 
At my doctor appointment in September, he mentioned there is a new study out showing the positive effects of low daily dosing of PT141 versus the "on demand" high dose protocol. Similar benefits but much lower sides. I will see if I can get my hand on it and post here.

In the meantime, I had him call it in for me based on the lower dosing instructions. I will report back in due time.
Thanks! What is your doc's low dosing regimen?
 
Sorry no info yet. Been so busy haven't been able to get going on the daily dosing program. Hope to give it a try once life calms down a bit.
 
I haven't seen an update to this thread for a while. I was wondering how you guys are doing with low libido and this protocol.
 
I haven't started yet. Doing some year end shock wave sessions which really boost EQ for me. Not sure I want to do both at the same time. Will keep you posted.
 

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