PT - 141 (Bremelanotide) for Improved Sex Drive (Libido) and Erections

[Nelson Vergel]

• Bremelanotide (PT 141) is a synthetic melanocortin compound
• It is a ‘melanocortin receptor agonist’- activates melanocortin receptors in the body
• ‘Melanocortins’ refer to a group of peptide hormones derived in the pituitary gland
• Several melanocortins have been identified, each producing different effects
• Researchers have investigated multiple synthetic melanocortin compounds for different uses including:
– Aphrodisiac drug; tanning agent; anti-obesity
– Studied for effects on mood and cognition
-Used to treat sexual dysfunction or used to improve sexual performance in healthy patients
• Produces multiple effects that influence sexual response including a noticeable increase in desire, increased libido, increase in physical response, vaginal vasocongestion (women), and erection (men)

SIDE EFFECTS:

• Nausea
• Hypertension
• Flushing
• Priapism (men)
• Injection site reactions
• Headache
• <4% reported in Vyleesi trials

PHARMACEUTICAL PRODUCT APPROVED IN THE US FOR WOMEN:

• Commercially available as Vyleesi™
– Specific indication
– One time use injection pen with two dose options
– >$2000 retail price for four (4) doses
– Not covered by insurance for off-label uses
– Only commercial product in the US that contains bremelanotide

OFF-LABEL USES:

• Hypoactive sexual desire disorder (HSDD) in premenopausal women
• Sexual dysfunction in men
• Erectile dysfunction
• Premature ejaculation
• Low libido; underactive sex drive
• Lack of desire
• Low response to sexual stimulation; anorgasmia

COMBINATION THERAPY:


• Some doctors prescribe a combination of two or more treatments to effectively treat the complex issues that result in sexual dysfunction
• Bremelanotide + Sildenafil has been shown to enhance erectile response in some patients
• Men with low testosterone + sexual dysfunction are often given TRT

COMPLEMENTARY PRODUCTS USED WITH PT 141

• Sildenafil (capsules, ODTs, troches)
• Tadalafil (capsules, ODT, troches)
• Vardenafil (capsules, ODT, troches)
• Bimix, Trimix, or Quadmix (+ Supers)
• Testosterone (cream, injectable, pellets, nasal gel)
• Arousal Cream
• Oxytocin (nasal spray or troches)
• Premature ejaculation (PE) medications

Erection peptide: Pt-141

When I have used Melanotan II I get very, very sexually aroused. But, when I have tried PT-141...nothing. I use 1.5mg Melanotan II. I have tried up to that much PT-141. Who here has tried Pt-141? Anyone else get horny using Melanotan II ? BTW, I get really very tan!!!

www.excelmale.com

PT 141

Good morning, I recently received PT 141 from a compounding pharmacy with a script from my provider. I'm a little confused about dosing even after speaking to my provider about this. I received a 2 milliliter vial which states 10,000mcg/10mg per milliliter. The instructions state inject 2-5...

www.excelmale.com

The Amazing Bremelanotide PT-141 (Vyleesi)

Bremelanotide PT-141 is a promising treatment option for men experiencing sexual dysfunction, particularly those struggling with low libido and erectile issues. This synthetic peptide works differently from traditional ED medications like Viagra or Cialis, targeting the nervous system rather...

www.excelmale.com

Why so little info on Bremelanotide (PT-141-Vyleesi)?

There is an astonishing lack of talk on here about a drug which attempts to address something that we talk about all the time and have zero tools to fix - libido. Now that we have multiple phase three studies to review on Pubmed and an FDA approved product perhaps we need to start gathering...

www.excelmale.com

PT-141 and Trimix?

Just putting my feelers out there before I experiement myself. Has anyone used both PT-141 and Trimix? Since they work on seperate systems I don't think there will be much of a chance of complications but just curious what you guys think. Thanks!

www.excelmale.com

Libido Peptide for Men and Women: PT 141 (Brand: Vyleesi for Premenopausal women)

If one were to use pt 141 and it was successful does that imply anything? In other words, the mechanism that made it work can that be made to do the same thing with any other supplement or drug that doesnt have the pt 141 side effects? Im tired, not sure im typing this right. Is there another...

www.excelmale.com

Has anyone used PT-141 to improve erections?

I am curious re: the peptide PT-141. It sounds like it is useful for those suffering from ED and sex drive/sexual satisfaction issues. Does anyone here have experience with this? Is it safe to use? What kind of dosage?? Regards, Gemini99

www.excelmale.com

Lecture: What You Should Know About CJC-1295 with Ipamorelin, PT-141 also known as Bremelanotide, and BPC-157

Table of Contents Transcription Of CJC-1295 with Ipamorelin Good afternoon, everyone, and thank you for joining us for today's webinar on some new products being offered by Wells Pharmacy Network. We're going to talk about three new items: CJC-1295 with Ipamorelin, PT-141 also known as...

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[Nelson Vergel]

PT 141 diminishing effect on erections?

Has anyone experienced diminishing effect from Pt 141 over time? It worked extremely well for me the first few uses but got less and less over time. The side effects, nausea and muscle soreness, did not decrease. The vial, which I keep refrigerated, is a couple months old. Could it degrade...

www.excelmale.com

 

[Nelson Vergel]

Libido Peptide for Men and Women: PT 141 (Brand: Vyleesi for Premenopausal women)

If one were to use pt 141 and it was successful does that imply anything? In other words, the mechanism that made it work can that be made to do the same thing with any other supplement or drug that doesnt have the pt 141 side effects? Im tired, not sure im typing this right. Is there another...

www.excelmale.com

 

[KGB197]

Yes I experienced the same. I was using it probably 3x/week and noticed by time I got done with a 2nd 2 ML vial the effects were not as good. I took a couple of months off and I am seeing the benefits again, although still not as strong as when I first started taking it. I only take is 2x/week max now. Halandale Pharmacy seems to be a good source. Peptide Sciences I was not as impressed, but that maybe because I was already using it for awhiel before I took a break from it. The muscle soreness is my major isue with it. I feel like I was in a car accident for a couple of days afterwards (I have a lot of old injuries).

 

[Nelson Vergel]

What are your experiences with PT-141? (as an aphrodisiac)

I found this thread submitted by @Nelson Vergel : PT 141 forum But it is only general information. Does anyone here use PT-141 for assistance with arousal? How has it been? I just got approved for this treatment since I have been disinterested in sex recently... (I haven't felt the need to...

www.excelmale.com

 

[Nocalves]

Is there any tips/tricks how to avoid nausea and hot flushes after injection.
Works good for libido and erection, but sides are unbearable.

 

[DorianGray]

Is there any tips/tricks how to avoid nausea and hot flushes after injection.
Works good for libido and erection, but sides are unbearable.

Some people have such reactions, others not. You may be more sensitive to it. You can try reducing dose to level where you do not get symptoms then gradually increase it with subsequent sessions.

 

[Guided_by_Voices]

I think the side effect and desensitization issues come from people taking way too much. I take less that .5mg 2 or 3 times a week and I get a consistent boost although not the unnatural boost that many report at higher doses. Another thing to be careful of is that there is still a tanning-amplification affect but much less that MTII which IMO is unusable in all but the winter months for that reason. Dr. Hertoghe has a protocol where he recommends building up gradually from .1mg. I've also heard that for people bothered by the flushing issue, taking a shower right after the injection will mitigate the flushing, although it hasn't been much of an issue for me so I haven't tried that.

 

[Goel]

PT-141 is supposed to be injected sub-Q, but purely out of curiosity what would be the result of IM injection instead?

 

[lutherdingle2]

Didn't help me at all.

 

[52hoosier]

Has anyone tried Pt-141 from Empower? I have tried it from Peptide Science. It did not produce full results other than making me sick to my stomach. Would there be any difference in potency and side effects? There is certainly a difference in price.

 

[tropicaldaze1950]

How about compounded intranasal bremelanotide? I just sent an email to a local compounding pharmacy. My urologist would rx it. I know injectable PT-141 isn't expensive but a nasal spray would be so convenient.

 

[Nelson Vergel]

PT-141:Future Dopamine-Related Erectile Dysfunction Cure For Some Men.

PT-141 should never be used without a doctor. It is a melanocortin and melanocortins are involved in anhedonic depression.

www.peaktestosterone.com

 

[modernist]

I'm 52 years old. The first time I used PT-141 about 7 years ago, I thought I found the holy grail. Spontaneous rock hard erections for 24 hours. But after that first time, results have been mixed to the point that I only rarely try it now. Worst side effect is horrible nausea that lasts for 2 to 3 hours. I last used it about a week ago for the first time in a few years and felt a bit nausea, and the next day did have increased turgidity throughout the day but no full on erections like my first use long ago. For the record, I'm on TRT and take daily Cialis, between 6 and 12 mg per day.

 

[tropicaldaze1950]

Possibly, takyphylaxis. My urologist explained it to me. It's where the body/brain stop responding to a medication. It's not the same as developing drug tolerance. I have bipolar illness and a history of drug failures. Likewise, testosterone injections never restored erectile function. Can't tolerate PDE-5 inhibitors. Problems even with thyroid medication. He believes that I'm experiencing takyphylaxis. He called in a prescription to Empower for PT-141. I never ordered it. Don't want to be disappointed and, worse, sick form any side effects.

 

[50BMGdoesitforme]

Hey all - I've had really good results taking 750 mcg pf PT-141 (if my math is right, it's .15ml of 10mg/ml), and decided to try Melanotan 2 for the added tanning benefit. I'm just a little confused on the right way to dose it; at 750 mcg of PT-141, I get substantial nausea (less if taken on a full stomach, also going to try Taurine this next time) but excellent performance; 875mcg was a bit too much. Should I take 750mcg of Melanotan? I'm paranoid of turning a strange or uneven color - is there value in starting low and slowly increasing the dose? Does knowing how I respond to varying doses of PT-141 give me any useful info here?

Also, does the tanning effect happen immediately or does it take time? Just trying to avoid turning into a piece of wood and having to explain myself

Many thanks!

 

[Guided_by_Voices]

IME MT2 is way too strong for tanning and it gave me a tan with splotchy white spots. If you try it use the smallest possible dose. The effect comes on quite fast. I would recommend canthaxanthin instead for tanning. It is often faked but I had good results with the MASS brand. It seemed to help fix the splotches but they have persisted for years. They are not highly visible but that is likely because I was very cautious. For me. the tanning affect of PT-141 is more than enough. It will obviously vary based on where you are located, but less is more and you want to be really careful. Tyrosine is a key part of skin pigmentation so it would help to add that as well.

 

[Nelson Vergel]

A different dosing strategy with bremelanotide (PT-141) yields dramatically better results

TL;DR: It may be possible to improve results with bremelanotide by taking multiple daily micro-doses. Like many, I have experimented with bremelanotide at the recommended doses, which range from a few hundred micrograms up to a couple milligrams in one subcutaneous injection. And also like...

www.excelmale.com

 

[amex]

Hi Everyone,
I am looking for some help and info about this PT-141.
I already use this peptide since last November. But I felt really positive effect only at the very first time and only in the night and in the morning after that. And later some medium positive effect. Basically, I don't have ED or other problem with my erections. If I have a partner, my man part is absolutely working as normal. But... when I'm alone, I can't get sexually aroused. I can't manage my brain to get it. So the spontaneous erections missing from my day life. I am using this peptide, because basically all the information on the internet says this peptide cause spontaneous erections. This is what I want to reach. I already ordered from so many suppliers in the UK. I don't understand what the problem could be, but all of those orders were useless. I don't know that all UK sellers delivered fake product or just this peptide is effectless for my body. Few months ago, I read about this peptide can be used together with low dose Tadalafil/sildenafil or other ED tablet. I am tried that. Results was nothing! A bit later I started to take L-Arginine +L-Citrulline and of course daily 5mg Tadalafil+ 2mg PT-141. Same as when I started... The first night and morning was wonderful. After that absolutely no effect. If anyone understand what's wrong, please help me. Today I read about that this peptide can be take together with oxytocin. So P-141+ocytocin+ Tadalafil. Anyone tried this mix already?

 

[tropicaldaze1950]

This comes from my a conversation with my urologist: tachyphylaxis. A condition where a drug essentially stops working, sometimes quickly. It's not the same as tolerance. You can't overcome the problem by taking a higher dose. Maybe that's what you're experiencing. Just a guess. See what other guys have to say.