A different dosing strategy with bremelanotide (PT-141) yields dramatically better results

[Vince]

I haven't started yet. Doing some year end shock wave sessions which really boost EQ for me. Not sure I want to do both at the same time. Will keep you posted.

Sorry the meaning of EQ? I know it's not emotional intelligence.

 

[Golfboy307]

Hah! Sorry for the acronym. Erection Quality! I think that is old Peak T abbreviation.

 

[Nujace]

Let me know if you find out!

Cabergoline will lower prolactin in men and raise dopamine. It’s like a 3 day dopamine buzz when I have used it in the past. Probably much healthier ways to get it but since you asked…

 

[Golfboy307]

Gents, I thought I would update you on my daily dosing PT141 experiment. I finally got around to trying out multiple days recently. For reference, my doctor prescribed me compounded Bremelanotide from APS Pharmacy. The prescription reads: "Inject SubQ 0.01ML to 0.05ML daily for two weeks, followed by up to 3 times per week". The concentration on the bottle reads 1mg/0.1ML. In my head, if the typical dose of Vyleesi is 1.00 to 1.75Mg, he has me injecting less than 10% of that on a daily basis.

I tried a couple of one-time trial does at .01ML- .02ML (1-2 ticks on the insulin syringe). Both of these were in the afternoon. I noticed within about 10 minutes a very hot and red flushing of my face and neck. Lasted about an hour. No other sides, no nausea etc. In each instance I noticed some definite erectile "improvement" overnight. Better tingling, sensitivity and duration. Nothing off the chart however.

Given the flushing, I decided to try my consecutive daily doses injecting right before bed. That worked fine as I fall asleep very easily. Injected Thursday through Sunday. All I can say is "holy cow". Really strong and random erections throughout the night and into the next morning. I often complain to my wife that I seem to "lose the signal" and erections can go numb and limp at the wrong time. If PT141 helps the brain signal the penis, it certainly seemed to work that way for me. Had a hard time bringing a few of those boners back down. Wife was enlisted to help...

I think for now I am going to keep this small dosing to 3-4 days a week and see how it goes. I don't want to burn out the receptors. Given my relatively small dosing, I would NOT want to ever take a full dose that you often see prescribed. Can't imagine the sides.
I am not totally sure how this compares to the data points in the original post. But credit my doctor for giving this a try. I am hopeful it will be a good tool for the long term. Keep you posted!

 

[Guided_by_Voices]

Gents, I thought I would update you on my daily dosing PT141 experiment. I finally got around to trying out multiple days recently. For reference, my doctor prescribed me compounded Bremelanotide from APS Pharmacy. The prescription reads: "Inject SubQ 0.01ML to 0.05ML daily for two weeks, followed by up to 3 times per week". The concentration on the bottle reads 1mg/0.1ML. In my head, if the typical dose of Vyleesi is 1.00 to 1.75Mg, he has me injecting less than 10% of that on a daily basis.

I tried a couple of one-time trial does at .01ML- .02ML (1-2 ticks on the insulin syringe). Both of these were in the afternoon. I noticed within about 10 minutes a very hot and red flushing of my face and neck. Lasted about an hour. No other sides, no nausea etc. In each instance I noticed some definite erectile "improvement" overnight. Better tingling, sensitivity and duration. Nothing off the chart however.

Given the flushing, I decided to try my consecutive daily doses injecting right before bed. That worked fine as I fall asleep very easily. Injected Thursday through Sunday. All I can say is "holy cow". Really strong and random erections throughout the night and into the next morning. I often complain to my wife that I seem to "lose the signal" and erections can go numb and limp at the wrong time. If PT141 helps the brain signal the penis, it certainly seemed to work that way for me. Had a hard time bringing a few of those boners back down. Wife was enlisted to help...

I think for now I am going to keep this small dosing to 3-4 days a week and see how it goes. I don't want to burn out the receptors. Given my relatively small dosing, I would NOT want to ever take a full dose that you often see prescribed. Can't imagine the sides.
I am not totally sure how this compares to the data points in the original post. But credit my doctor for giving this a try. I am hopeful it will be a good tool for the long term. Keep you posted!

What you've arrived at seems very similar to my approach. Many people elsewhere have reported that sleep seems to be necessary to "activate" its effect so I've always used the before-bed approach. It would be interesting to know if the pharma PT-141 you have and the Peptide Sciences version has about the same potency. More good citizen science.

 

[amex]

What you've arrived at seems very similar to my approach. Many people elsewhere have reported that sleep seems to be necessary to "activate" its effect so I've always used the before-bed approach. It would be interesting to know if the pharma PT-141 you have and the Peptide Sciences version has about the same potency. More good citizen science.

It is depend on that where the Peptide Science get their peptide from.
For example, in the UK the PT-141 (Bremelanotide) is not approved and cannot be purchased legal (pharmaceutical version) privately. So it looks all UK seller get their peptide from China. So what exactly is in the glass bottle.... No one knows ....But it is 100% not pure peptide powder. Otherwise the peptide couldn't be effectless, as me and many other people reported.

 

[Cataceous]

...
I am not totally sure how this compares to the data points in the original post. But credit my doctor for giving this a try. I am hopeful it will be a good tool for the long term. ...

It is good to see a doctor taking a step in the right direction. There is a tradeoff between what's practical and what's effective, and this approach still favors the practical. It sounds like your lowest dose was 100 mcg in one daily injection. This is comparable to the total of the 5 x 20 mcg injections per day discussed in the original post. However, my sense is that some peptides act differently and/or with less potency when delivery is relatively infrequent. Consider that endogenous α-MSH is probably secreted continuously at much lower levels. Bremelanotide is aided by its much longer half-life, but at under three hours it still cannot provide a reasonable imitation of natural activity when give once daily.

In any case, I'm still hoping someone will take one for the team by trying distributed dosing for a few days — e.g. 5 x 20 mcg/day — to see if the results are similar to what's reported above. If there's previous use then there should be a decent washout period beforehand. A few weeks, perhaps?

 

[Golfboy307]

Thanks Cat! I appreciate the decimal conversion/comparison. While I had really nice results for that initial 3–4-night dosing period, it will be interesting to see if this can be repeated on a long-term basis.

 

[phalloguy100]

I just happened to find this thread while looking into PT-141. I recently got one bottle from BioTech Peptides and did 200mcg in the morning (day 1). Nothing. At night however, I woke up a couple of times extremely aroused to the point I had to release “manually” to be able to sleep.

The next day (day 2), there was still an improvement in libido. Had some really good sex in the middle of the day, and strangely, I felt really good the rest of the day as if I had taken antidepressants.

On day 3, I injected 300mcg in the morning. Again, nothing. But at noon, I took a 40 minute nap and woke up super, super horny. This continued all day. At night we had rough sex, for a long time.

Today, day 4, I have been so freaking horny all day long, with massive spontaneous erections (granted I also take cialis daily). Got some oral in the shower in the morning, and it was so sensitive at the head that it felt way better than usual. I took a nap in the evening and I kept waking up because my dick was so hard and sensitive that I couldn’t take the rubbing against my underwear.

So it definitely worked for me - it increased libido ten-fold, EQ and sensitivity. But, after reading this thread, I would hate for it to lose its effectiveness via high doses. I will have to try the lower dosage protocol mentioned here and report back. That is, once the 2 high doses are finally out of my system in the first place!

 

[Golfboy307]

Thanks for posting! Glad to hear another early success story with lower daily dosing. Again, it seems like sleep triggers something positive in the process.

 

[phalloguy100]

Yeah, sleep definitely triggers something, and it appears to be required for pt-141 to work. No idea why that is…

 

[Nelson Vergel]

Great thread, guys. I have only tried PT-141 once (forget the dose) and hated the tachicardia I felt (no erections at all).

I was curious about what happened with the phase 2 study that Palatin Technologies was doing with nasal PT-141 in 2017. This is what I found out today (AI generated)

What is the status in 2023 of Palatin Technologies study using PT-141?​

️ Answer​

In 2023, Palatin Technologies initiated a clinical program for a novel co-formulation involving bremelanotide, also known as PT-141. This program specifically targeted the treatment of erectile dysfunction (ED) in patients who are non-responsive to PDE5i treatment. The initial trial of this development program was set as a Phase 2 clinical study of bremelanotide co-formulated with a PDE5i. This indicates ongoing research and development efforts by Palatin Technologies in the field of sexual dysfunction treatments, particularly focusing on advancing the applications of PT-141 in new therapeutic areas [1], [2].

Sources​

• palatin.com - Palatin Initiates Clinical Program for Bremelanotide Co
• prnewswire.com - Palatin Initiates Clinical Program for Bremelanotide Co
• adisinsight.springer.com - Palatin Technologies - Bremelanotide
• sciencedirect.com - Co-administration of low doses of intranasal PT-141
• newdrugapprovals.org - PT 141
• wikipedia.org - Bremelanotide

I think they have changed their focus to a co-formulation (injectable):


"Working with a collaborator, Palatin has developed a co-formulation of bremelanotide and a PDE5i which can be administered as a single injection. The initial trial for the clinical development program for this novel co-formulation will be a Phase 2 clinical study of bremelanotide co-administered with a PDE5i in ED patients who have not responded to PDE5i treatment. This study is currently expected to start in the fourth quarter of the calendar year 2023."

Palatin Initiates Clinical Program for Bremelanotide Co-Formulated with a PDE5i for the Treatment of ED in Patients Non-Responsive to PDE5i Treatment

/PRNewswire/ -- Palatin Technologies, Inc. (NYSE American: PTN), a biopharmaceutical company developing first-in-class medicines based on molecules that...

www.prnewswire.com

 

[Golfboy307]

Makes sense. Already on a similar version of the "combo": 5-7mg Cialis and the low dose Brem. I get that a company would want to commercialize a version.

 

[phalloguy100]

Just a few days after starting the low dose, several people made comments about how "tanned" I look. Given its dead middle of winter, it's kind of hard to explain.

 

[Guided_by_Voices]

Just a few days after starting the low dose, several people made comments about how "tanned" I look. Given its dead middle of winter, it's kind of hard to explain.

I find that PT-141 still has a tanning effect if you're exposed to the sun. Not as much as MT2, but still there.

 

[Golfboy307]

I repeated the three night in a row dosing 0.01 to 0.02ML (Thursday, Friday Saturday). Same positive results: modest effect the first night, very strong erections the next two. Same side effect of flushing. Maybe some additional muscle aches, but that could have been workout related.

Haven't noticed any tanning..

 

[phalloguy100]

I stopped the low dose of PT-141 because I started a new T protocol and didn’t want to get mixed results. After T levels are stable, I’ll retry low dose PT-141 and post here if there were any changes in libido or EQ.

 

[Willyt]

Ok I'm game as always to experiment with the microdosing. I plan to start at single 10-20mcg injection and then start tweaking variables like number of injections per day and duration of multi-day break as mentioned above to avoid desensitization.

From a practical perspective, how much bacteriostatic water is needed to reconstitute a 10mg (10,000 mcg) vial of PT-141 from Peptide Sciences to accommodate microdoses as small as 10-20 mcg?

And what size insulin syringe is best for the injection of such a small amount? (I have a wide variety of sizes from all of my enanthate-propionate blend experiments!)

 

[Cataceous]

Ok I'm game as always to experiment with the microdosing. I plan to start at single 10-20mcg injection and then start tweaking variables like number of injections per day and duration of multi-day break as mentioned above to avoid desensitization.

From a practical perspective, how much bacteriostatic water is needed to reconstitute a 10mg (10,000 mcg) vial of PT-141 from Peptide Sciences to accommodate microdoses as small as 10-20 mcg?

And what size insulin syringe is best for the injection of such a small amount? (I have a wide variety of sizes from all of my enanthate-propionate blend experiments!)

Considering that you'll be using less than 100 mcg per day, and it's probably best not to let the stuff sit in the fridge for more than a month, I recommend splitting the hydrated peptide into at least four aliquots and freezing all but one. My experience jibes with the general statement that peptides don't lose much potency in a single freeze-thaw cycle. If you're using an ordinary refrigerator that defrosts on occasion then it may be good to put frozen peptides in an insulated bag with cold packs to buffer against temperature changes. For 10 mg of PT-141 I'd want a minimum of 10 mL of bacteriostatic water. With this amount you can reasonably measure doses in 5 mcg increments with certain 0.3 mL, U-100 insulin syringes; the Easy Touch, for example, have 0.005 mL graduations.

 

[phalloguy100]

Google “peptide calculator” - several peptide sites have one to help you figure out bac water and dosages.

E.g.:

Peptides Dosage Calculator | Peptides.org

The premier peptides dosage calculator on the interwebs. Here researcher's will be able to dial in any research chemical dosing needs with ease.

www.peptides.org