High reverse T3 the cause of high SHBG?

[Vvs1]

My SHBG is high. I believe I ruled out all other causes of high SHBG- sensitive e2 is on the lower end of normal, increased my Vitamin D to well over 100, natural testosterone is 8-900, and DHT is normal.

Last cause is thyroid.
Comprehensive thyroid panel was good except for a very high reverse T3. So being that T4 and T3 are normal, there’s technically extra thyroid circulating in reverse T3.

I know that reverse T3 is considered opposing, but maybe it doesn’t matter when the body/liver noticed it and makes extra SHBG?

 

[Systemlord]

My SHBG is high. I believe I ruled out all other causes of high SHBG- sensitive e2 is on the lower end of normal, increased my Vitamin D to well over 100, natural testosterone is 8-900, and DHT is normal.

Androgens balance SHBG levels, high level of androgens the lower SHBG.

Your SHBG is high because your free testosterone level is on the lower end. One way this can happen is starvation, which lowers your testosterone production while also increasing your SHBG.

Normally when one has low free testosterone, it’s not uncommon to also find low estrogen, because estrogen is converted from free testosterone.

I’ll bet you you’re free testosterone levels mirror that of your estrogen levels.

I know that reverse T3 is considered opposing, but maybe it doesn’t matter when the body/liver noticed it and makes extra SHBG?

Stop testing for reverse T3, because it’s biologically inactive.

 

[Vvs1]

Androgens balance SHBG levels, high level of androgens the lower SHBG.

Your SHBG is high because your free testosterone level is on the lower end. One way this can happen is starvation, which lowers your testosterone production while also increasing your SHBG.

Normally when one has low free testosterone, it’s not uncommon to also find low estrogen, because estrogen is converted from free testosterone.

I’ll bet you you’re free testosterone levels mirror that of your estrogen levels.

Stop testing for reverse T3, because it’s biologically inactive.

I was far from starvation but still had symptoms of low blood sugar, but also thyroid issues. Such as couldn’t stand the cold at all, I’d walk a very short distance to my car in 35F degrees and would shiver hard for 10 minutes until I could drive. Or in warm weather, a short walk would have me drenched in sweat like underboob sweat, and dripping down my face. Brain fog no matter the weather.

 

[Systemlord]

I had cold intolerance when I had low testosterone and in the summer, I was sweating like you wouldn’t believe.

 

[Vince]

My SHBG is high. I believe I ruled out all other causes of high SHBG- sensitive e2 is on the lower end of normal, increased my Vitamin D to well over 100, natural testosterone is 8-900, and DHT is normal.

Last cause is thyroid.
Comprehensive thyroid panel was good except for a very high reverse T3. So being that T4 and T3 are normal, there’s technically extra thyroid circulating in reverse T3.

I know that reverse T3 is considered opposing, but maybe it doesn’t matter when the body/liver noticed it and makes extra SHBG?

Can you post your thyroid levels along with ranges

 

[Vvs1]

Can you post your thyroid levels along with ranges

Here’s one set while I look for the comprehensive thyroid panel. Thanks

 

[Gman86]

Here’s one set while I look for the comprehensive thyroid panel. Thanks

How u feeling with these labs? They all look pretty good, so I’m just curious. I personally would need my free T higher than that to feel optimal, but I’m curious how ur feeling with these numbers

 

[Systemlord]

curious. I personally would need my free T higher than that to feel optimal

Also note, he’s using the Direct method for testing free testosterone which tends to overestimate, making things look better than they really are.

 

[Gman86]

Also note, he’s using the Direct method for testing free testosterone which tends to overestimate, making things look better than they really are.

Oh wow, ya I would have low T symptoms at that free T level for sure. I actually did before I got on TRT. My total T was higher than his, and free T was about the same on one test, and slightly lower on another. So I’m curious how he’s doing with these levels. Maybe these are his trough levels on like a twice weekly or once weekly injection schedule

 

[Systemlord]

Oh wow, ya I would have low T symptoms at that free T level for sure. I actually did before I got on TRT. My total T was higher than his, and free T was about the same on one test, and slightly lower on another. So I’m curious how he’s doing with these levels. Maybe these are his trough levels on like a twice weekly or once weekly injection schedule

I was listening to a podcast of Dr. Rob Kominiarek the other day and he was talking about if someone has toxicity in the body and he gives the a short acting oral testosterone and they don't feel something within 30 minutes, then that person has low receptor density and will never respond to testosterone until they detox.

Medical problem can a will prevent one from feeling the full effects of hormones.

 

[Gman86]

I was listening to a podcast of Dr. Rob Kominiarek the other day and he was talking about if someone has toxicity in the body and he gives the a short acting oral testosterone and they don't feel something within 30 minutes, then that person has low receptor density and will never respond to testosterone until they detox.

Medical problem can a will prevent one from feeling the full effects of hormones.

Ya I think a lot of people are starting to realize that receptor sensitivity plays a big role in how people do taking exogenous compounds, and how well they do with certain levels of endogenous hormones, as well, I would assume. I think the whole insulin sensitivity stuff has really opened people’s eyes to this concept. Everyone knows insulin sensitivity/ insensitivity is a real thing, and insulin receptors can’t be the only receptors that this can happen to. I would assume it can happen to any receptor on a cell.

I’ve been watching a lot of this guys vids lately. He has really really good info, imo. And he firmly believes that a guy taking exogenous test will need higher serum levels to get the same benefits as other men do with lower, but endogenous, levels. Aka a guy on trt might need a total of 1000, to feel similar to a guy that’s natural with a total of say 500-700, for example. Is he right? Idk lol. He could be. He believes it tho, and he’s got a good grasp on HRT, imo, and has the advantage of having helped thousands of clients over the past 10 years or so

https://m.youtube.com/@CortexLabsChannel/videos

 

[Systemlord]

Ya I think a lot of people are starting to realize that receptor sensitivity plays a big role in how people do taking exogenous compounds, and how well they do with certain levels of endogenous hormones, as well, I would assume. I think the whole insulin sensitivity stuff has really opened people’s eyes to this concept. Everyone knows insulin sensitivity/ insensitivity is a real thing, and insulin receptors can’t be the only receptors that this can happen to. I would assume it can happen to any receptor on a cell.

I’ve been watching a lot of this guys vids lately. He has really really good info, imo. And he firmly believes that a guy taking exogenous test will need higher serum levels to get the same benefits as other men do with lower, but endogenous, levels. Aka a guy on trt might need a total of 1000, to feel similar to a guy that’s natural with a total of say 500-700, for example. Is he right? Idk lol. He could be. He believes it tho, and he’s got a good grasp on HRT, imo, and has the advantage of having helped thousands of clients over the past 10 years or so

https://m.youtube.com/@CortexLabsChannel/videos

Dr. Rob Kominiarek also talking about inflammation blocking the effects of testosterone, he talked about by-lipid membrane inflammation blocking the effects on hormones at the receptors.

I never responded to 1-2 weekly injection, even with very high levels at trough!

Dr. Rob Kominiarek said the only way to bypass that problem is to use the short acting delivery systems, such as topicals and oral testosterone that spike hormone rapidly thus overcoming the by-lipid membrane inflammation/insulin insensitivity issues.

The oral testosterone is the only delivery method that has ever worked for me.

 

[Vvs1]

How u feeling with these labs? They all look pretty good, so I’m just curious. I personally would need my free T higher than that to feel optimal, but I’m curious how ur feeling with these numbers

Not kidding when I say this, but I feel like a eunuch.

 

[Vvs1]

SHBG and my crazy vitamin D when I was supplementing. Thyroid panel soon when my account is recovered.

 

[Systemlord]

View attachment 43830
SHBG and my crazy vitamin D when I was supplementing. Thyroid panel soon when my account is recovered.

I’m sorry to be the one to tell you this, but decreasing SHBG yeah isolation will not increase free testosterone. LH stimulation and the testicles response to stimulation is the only thing that will increase free testosterone.

 

[Gman86]

Dr. Rob Kominiarek also talking about inflammation blocking the effects of testosterone, he talked about by-lipid membrane inflammation blocking the effects on hormones at the receptors.

I never responded to 1-2 weekly injection, even with very high levels at trough!

Dr. Rob Kominiarek said the only way to bypass that problem is to use the short acting delivery systems, such as topicals and oral testosterone that spike hormone rapidly thus overcoming the by-lipid membrane inflammation/insulin insensitivity issues.

The oral testosterone is the only delivery method that has ever worked for me.

Very interesting stuff! Love progress/ breakthroughs/ great critical thinking skills like this! It’s little discoveries like this that can make all the difference for some guys/ people

 

[Gman86]

View attachment 43830
SHBG and my crazy vitamin D when I was supplementing. Thyroid panel soon when my account is recovered.

Oh ur natural? Not on hrt?

And how many iu’s of vitamin D were u taking during these labs? And how many iu’s are u currently taking?

 

[Gman86]

Not kidding when I say this, but I feel like a eunuch.

Ya I remember how I felt with even higher total T levels than u, but pretty similar free T levels, and my SHBG was slightly lower than urs at 55. I felt horrible! That was when I was around 27. Felt so much better once I started HRT. And have realized, through trial and error over the years, that I need a pretty high free T level to feel optimal. Around 40ish, or so

 

[Vvs1]

Oh ur natural? Not on hrt?

And how many iu’s of vitamin D were u taking during these labs? And how many iu’s are u currently taking?

That’s natural, and even seen just shy of 1000. But my endo said my testes were on the small side. I’m not on any hrt.

I took a liquid vitamin D in December before the test. Just a small dose every day or every other day. Thought I was deficient after working for years with not much sunlight. It was a small dropper bottle and didn’t finish the bottle.

I’m honestly not sure of the IUs but likely around 5k. Haven’t taken vitamin D since the test.

 

[Vvs1]

Ya I remember how I felt with even higher total T levels than u, but pretty similar free T levels, and my SHBG was slightly lower than urs at 55. I felt horrible! That was when I was around 27. Felt so much better once I started HRT. And have realized, through trial and error over the years, that I need a pretty high free T level to feel optimal. Around 40ish, or so

Did you have morning/nocturnal wood with a high Shbg? I don’t but then idk if that’s the problem