Hormones

Older Men Metabolize Testosterone More Slowly Than Young Men

Jan 18

Why Older Men May Need Less Testosterone: The Surprising Science of Metabolic Clearance 1. Introduction: The Hormonal Paradox In the world of hormone replacement therapy and longevity, the prevailing assumption is often that "more is better." If...

Hormones Men's Health Testosterone

The Testobolome: How Your Gut Bacteria Control Your Testosterone

Jan 14

What You Need to Know Scientists have discovered that the trillions of bacteria living in your gut don't just help you digest food—they also control how much testosterone your body has available to use. They're calling this system the...

Hormones Men's Health Nutrition TRT Women's Health

Sex Hormone Binding Globulin (SHBG): The Complete Guide for Men on TRT

Jan 02

By Nelson Vergel | ExcelMale.com | Updated December 2025 When evaluating testosterone levels, most men focus exclusively on total testosterone—a single number that tells only part of the story. What many don't realize is that a protein called...

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Key Historical Failures and Lessons Learned from Attempts to Get a Testosterone Product FDA-Approved for Women

Dec 12

FDA Approval of Testosterone Therapy for Women: An Analysis of Historical Failures, Regulatory Hurdles, and a Path Forward Executive Summary The landscape of testosterone therapy presents a stark gender disparity: while over 31 FDA-approved...

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HCG Use in Men on TRT or as Monotherapy: Over 200 Questions and Answers

Dec 05

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I collected questions and answers posted on ExcelMale.com in the last 10 years about the use of human chorionic gonadotropin in men who want to prevent loss of testicular size and fertility while on testosterone replacement therapy or that want...

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Nandrolone (Deca Durabolin): Effect on Lab Tests

Nov 28

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PARTICIPATION NEEDED! Of those EM members that have taken nandrolone or are currently taking nandrolone alongside their TRT, we are conducting a small ExcelMale study to help determine the effect that nandrolone has on Total Testosterone, E2...

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Clomiphene Citrate (Clomid) in Men With Low Testosterone - Do we Need to Monitor IGF-1 in All Patients?

Nov 26

Is Clomid (clomiphene citrate) a good alternative to TRT for men with low testosterone? Clomiphene can raise testosterone levels while preserving fertility—making it attractive for younger men who want to avoid testicular shutdown. But new...

Clomid (Clomiphene & Enclomiphene) Fertility Hormones Men's Health Muscle Gain

Practical Clinical Summary on Testosterone Therapy in Women

Nov 25

Practical Clinical Summary on Testosterone Therapy in Women (From ExcelMale.com) Based on the ExcelMale forum threads and related clinical literature, here's a comprehensive extraction of practical content for a clinical article: Physiological...

Health & Wellness Hormones Testosterone TRT Women's Health

Ozempic's and GLP-1 Inhibitors' Impact on Sexual Function

Nov 24

Today we are joined by Dr. Rahul Mehan, a renowned urologist, who sheds light on the impact of Ozempic on sexual function, particularly in relation to erectile dysfunction. He is also the founder of Snip City, which specializes in vasectomy...

Health & Wellness Hormones Men's Health Sex drive Weight Loss Women's Health

FDA Removes Black Box Warning: What the New HRT Guidelines Mean for Women’s Health and HRT

Nov 17

Dr. Rachel Rubin and Dr. Kelly Caspersen discuss with FDA Commissioner Dr. Marty Makary the significant impact of hormone replacement therapy (HRT) on women's health, particularly in the context of recent FDA changes to black box warnings. They...

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How Anabolic Agents Can Save Your Muscles: One Man's Journey from Death Sentence to Thriving at 66

Nov 17

Can testosterone and anabolic agents reverse muscle wasting? This is the story of how hormone therapy transformed HIV treatment—and what it means for men's health today. Nelson Vergel was diagnosed HIV-positive in 1985 when it was a death...

https://www.defymedical.com/get-started/.

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The pharmaceuticalization of ‘healthy’ aging: Testosterone enhancement for longevity

Nov 11

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Abstract The United Nations estimates that the world’s population will reach 8.5 billion by 2030, and the populations of most countries are expected to grow older. This is the case for many developed countries, including Australia, the United...

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