Hormones

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The FDA Announces Changes to HRT Product labels
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Great news today FDA Updates Hormone Therapy Labels: A Significant Shift in Menopausal Treatment Guidance In a major policy reversal announced today, the FDA has approved updated labeling for six menopausal hormone therapy (HRT) products...
Protect Your Access to Compounding Products- Submit Your Testimonial
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Dear ExcelMale Members, I'm reaching out to you today with a request that's deeply personal to me and I believe to many of you as well. As some of you know, compounded medications literally saved my life. In the early days of the AIDS crisis...
Optimizing Fat Loss and Muscle Preservation: Tirzepatide + Oxandrolone + TRT + Protein & Exercise
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This article outlines a comprehensive strategy for optimizing fat loss and muscle preservation, primarily discussed within the context of an online forum dedicated to men's health, ExcelMale.com. The core of the strategy involves a multi-faceted...
New Free Hormone Calculator Suite Now Live on ExcelMale.com!
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All the TRT tools you need — in one place, completely free. We're excited to announce the launch of our new Hormone Calculator Suite, designed specifically for the ExcelMale community to help you better understand and manage your hormone...
Older Men Metabolize Testosterone More Slowly Than Young Men
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Why Older Men May Need Less Testosterone: The Surprising Science of Metabolic Clearance 1. Introduction: The Hormonal Paradox In the world of hormone replacement therapy and longevity, the prevailing assumption is often that "more is better." If...
The Testobolome: How Your Gut Bacteria Control Your Testosterone
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What You Need to Know Scientists have discovered that the trillions of bacteria living in your gut don't just help you digest food—they also control how much testosterone your body has available to use. They're calling this system the...
Sex Hormone Binding Globulin (SHBG): The Complete Guide for Men on TRT
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By Nelson Vergel | ExcelMale.com | Updated December 2025 When evaluating testosterone levels, most men focus exclusively on total testosterone—a single number that tells only part of the story. What many don't realize is that a protein called...
Key Historical Failures and Lessons Learned from Attempts to Get a Testosterone Product FDA-Approved for Women
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FDA Approval of Testosterone Therapy for Women: An Analysis of Historical Failures, Regulatory Hurdles, and a Path Forward Executive Summary The landscape of testosterone therapy presents a stark gender disparity: while over 31 FDA-approved...
HCG Use in Men on TRT or as Monotherapy: Over 200 Questions and Answers
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I collected questions and answers posted on ExcelMale.com in the last 10 years about the use of human chorionic gonadotropin in men who want to prevent loss of testicular size and fertility while on testosterone replacement therapy or that want...
Nandrolone (Deca Durabolin): Effect on Lab Tests
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PARTICIPATION NEEDED! Of those EM members that have taken nandrolone or are currently taking nandrolone alongside their TRT, we are conducting a small ExcelMale study to help determine the effect that nandrolone has on Total Testosterone, E2...

Clomiphene Citrate (Clomid) in Men With Low Testosterone - Do we Need to Monitor IGF-1 in All Patients?

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Is Clomid (clomiphene citrate) a good alternative to TRT for men with low testosterone? Clomiphene can raise testosterone levels while preserving fertility—making it attractive for younger men who want to avoid testicular shutdown. But new...
Practical Clinical Summary on Testosterone Therapy in Women
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Practical Clinical Summary on Testosterone Therapy in Women (From ExcelMale.com) Based on the ExcelMale forum threads and related clinical literature, here's a comprehensive extraction of practical content for a clinical article: Physiological...
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