Heart Health

Repatha (Evolocumab) Effects on Coronary Artery Calcium (CAC) Scoring and CCTA

Jan 16

Prepared: January 2026, Curated by Nelson Vergel Key Finding: Evolocumab induces significant coronary plaque regression and stabilization but does not differentially affect coronary calcium accumulation compared to statin monotherapy. However...

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Coronary Artery Calcium (CAC) scoring and Coronary Computed Tomographic Angiography (CCTA) in Men with Low Testosterone

Jan 16

Diagnostic Assessment Strategy: Cardiovascular Risk & Systemic Health in Hypogonadal Patients 1. Strategic Framework for Cardiovascular Risk in the Hypogonadal Male In the contemporary clinical landscape, the management of the hypogonadal male...

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Testosterone and Your Heart: What a Major New Study Really Found

Dec 29

Summary: The TRAVERSE trial, a landmark FDA-mandated study involving over 5,200 men, has definitively concluded that testosterone replacement therapy (TRT) does not increase the risk of major cardiovascular events like heart attacks, strokes, or...

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NO: The One Molecule That Supercharges Your Heart, Brain, Metabolism, and Sex Life (And Why Most People Are Dangerously Deficient)

Dec 02

What if one molecule controls your blood flow, oxygen delivery, metabolism, immunity, sexual function, and cognitive performance — and most people are critically deficient in it? In this episode of Metabolic Matters, Dr. Nasha Winters sits down...

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FDA Removes Black Box Warning: What the New HRT Guidelines Mean for Women’s Health and HRT

Nov 17

Dr. Rachel Rubin and Dr. Kelly Caspersen discuss with FDA Commissioner Dr. Marty Makary the significant impact of hormone replacement therapy (HRT) on women's health, particularly in the context of recent FDA changes to black box warnings. They...

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The Relationship Between Testosterone Therapy and Atrial Fibrillation: A U-Shaped Curve Hypothesis

Nov 14

Does testosterone therapy increase the risk of atrial fibrillation? The relationship between TRT and heart arrhythmias is more nuanced than headlines suggest. Recent research points to a U-shaped curve—both very low AND very high testosterone...

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From Phlebotomy to Formulation: Optimizing Hematocrit Control in Testosterone Therapy

Oct 23

Briefing Document: Optimizing Hematocrit Control in Testosterone Therapy Source: Excerpts from "From Phlebotomy to Formulation: Optimizing Hematocrit Control in Testosterone Therapy - Excel Male TRT Forum" 1. Executive Summary Testosterone...

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On TRT: How to check the state of cardiovascular system & how to find heart specialist

Sep 21

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Currently I (37m) am taking 20mg testosterone propionate and 150 IU hcg per day. doing that since a couple of months. I asked the doc if he can check my carotis intima and so on to see if there is soft plaque etc.... He said I need to go to...

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Unmasking Risks: Prevalence of Erythrocytosis Among Men on T-Therapy Across Different Formulations

Sep 17

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* The study population included men with (i) early morning total testosterone (TT) using LCMS, (ii) free T (FT) measured using equilibrium dialysis, and (iii) who were started on TTH. * Men using intramuscular or topical testosterone face a...

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How to Lower High Hematocrit Caused by Testosterone Replacement Therapy (TRT)

Jul 23

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Does testosterone therapy raise hematocrit levels? Yes—and understanding this common TRT side effect is crucial for your long-term health. Elevated hematocrit (the percentage of red blood cells in your blood) can increase cardiovascular risks if...

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FDA Expert Panel on Menopause and HRT Recommends Removing Black Box Labels

Jul 19

This was a very important meeting with top experts that are trying to change guidelines. This FDA panel recently recommended removing the warning (“black box”) labels on menopausal HRT, citing potential benefits like reduced heart attack and bone...

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Managing Erectile Dysfunction & Heart Health

Jul 18

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Dr. Dapo lluyomade * I think erectile dysfunction, we should really begin to think of erectile dysfunction as subclinical atherosclerosis until proven otherwise Is your patient’s sexual dysfunction an early indicator of serious...

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