Blood Tests

Pregnenolone in Men: Help determining proper dosage and frequency

Jun 21

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Hi all, I've been experimenting with pregnenolone for over a year now, with varied success. I seem to get benefits at 100mg (such as higher libido, more pronounced nighttime erections and better sleep); however, I don't get these results...

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WARNING: Do not believe Internet "gurus" proclaiming no need to manage hematocrit on TRT

Jun 17

Debunking the Myth About High Hematocrit in Men on TRT I know many of you want to feel reassured that managing hematocrit isn’t necessary. However, misinformation is spreading, with some "bro science" videos and even a few so-called expert...

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Testosterone Therapy Induced High Hematocrit- Can Therapeutic Phlebotomy Be a Double-Edged Sword?

Jun 14

https://ec.bioscientifica.com/view/journals/ec/aop/ec-24-0283/ec-24-0283.xml Therapeutic Phlebotomy: A Double-Edged Sword? Current Guidelines: "Several endocrine organizations mention therapeutic phlebotomy as a means of treating TTh–induced...

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Why Men’s Fertility Is Declining: The Truth About Testosterone

Jun 13

In an insightful interview from the "Dr. Gabrielle Lyon" YouTube channel, Dr. Larry Lipshultz, a renowned expert in male reproductive health, discusses the alarming global decline in male fertility, attributing it to factors such as obesity...

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High Estradiol in Men on TRT: What to Do

Jun 11

Briefing Document: Estradiol in Men on TRT Source: Excerpts from "High Estradiol in Men on TRT: What to Do" by Nelson Viegel (excelmale.com) 1. The Role and Importance of Estradiol in Men Core Idea: Estradiol, often misconstrued as a solely...

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Diagrams: Accurate Androgen and Estrogen Measurement in Human Serum and Plasma

Jun 06

* Probably the most challenging forms to quantify, due to their relatively low concentrations are the so called free forms. The free forms of all the hormones (shown in Figs. 1–3) are the hormones not bound to proteins, or conjugated to other...

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Testosterone blood level is correlated with immune cell abundance in transgender young people on gender affirming hormones

Jun 03

Sex hormones like estrogen and testosterone don’t just affect things like body shape or voice—they also play a role in how the immune system works. This is especially important for transgender people who take these hormones as part of their...

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Estradiol: The "Other" Male Hormone

May 31

Download slides (from my book "Beyond Testosterone"): Estradiol in Men Slides Estradiol in Men: The Stigma In the 2014 film The Other Woman, Cameron Diaz, Leslie Mann, and Kate Upton, portray three jilted females who discover they are...

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Managing the Testosterone-to-Estradiol Ratio in Men on TRT

May 29

Managing the Testosterone-to-Estradiol Ratio in Men on TRT Introduction Testosterone replacement therapy (TRT) in hypogonadal men often leads to an increase in estradiol (E2) levels due to the aromatization of testosterone. This alters the...

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The TRT Guide from ExcelMale.com

May 17

Understanding the Symptoms, Diagnosis, and Treatment of Hypogonadism in Men Hypogonadism, a condition characterized by low testosterone levels, can significantly impact a man's quality of life. ExcelMale.com offers a comprehensive guide to help...

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What Every Man Needs to Know | Testosterone 101

May 17

Testosterone is a key hormone for men's health, but what happens when levels drop? In this episode, Dr. Alex Tatem and KG break down everything you need to know about testosterone—what it is, signs of deficiency, when to get tested, and the best...

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Regular testosterone test overestimates hypogonadism in men compared to the LC-MS/MS assay

May 12

* IA compared to LC-MS/MS in hypogonadal men overestimates significantly both the prevalence of biochemical Hy and TRT compensation both for TT and cfT. These results highlight the role of LC-MS/MS and SHBG assessments in every day clinical...

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038