As we very well know T s metabolites estradiol and DHT are needed in order to reap full beneficial effects of testosterone. Ts metabolites estradiol and DHT are needed in healthy amounts to experience the full spectrum of testosterones...
Using hCG in Men on Testosterone Replacement Therapy (TRT) – A Clinical Review Introduction Exogenous testosterone replacement therapy (TRT) can profoundly suppress the hypothalamic-pituitary-gonadal (HPG) axis through negative feedback. By...
This scientific paper investigates the effects of smoking cessation on hormonal levels in men, specifically focusing on steroid hormones like testosterone, DHEA, DHEAS, cortisol, and sex hormone-binding globulin (SHBG). The researchers aimed to...
From this thread: WARNING: Do not believe Internet "gurus" proclaiming no need to manage hematocrit on TRT - Excel Male TRT Forum Underlying Physiological Mechanisms Testosterone Replacement Therapy (TRT) and Erythrocytosis: Exogenous...
Wondering what pregnenolone dose and frequency works best for optimizing your hormone balance on TRT? Pregnenolone, the "mother hormone" that serves as a precursor to numerous steroid hormones, requires careful dosing consideration due to its 3-4...
Debunking the Myth About High Hematocrit in Men on TRT I know many of you want to feel reassured that managing hematocrit isn’t necessary. However, misinformation is spreading, with some "bro science" videos and even a few so-called expert...
https://ec.bioscientifica.com/view/journals/ec/aop/ec-24-0283/ec-24-0283.xml Therapeutic Phlebotomy: A Double-Edged Sword? Current Guidelines: "Several endocrine organizations mention therapeutic phlebotomy as a means of treating TTh–induced...
Briefing Document: Estradiol in Men on TRT Source: Excerpts from "High Estradiol in Men on TRT: What to Do" by Nelson Viegel (excelmale.com) 1. The Role and Importance of Estradiol in Men Core Idea: Estradiol, often misconstrued as a solely...
* Probably the most challenging forms to quantify, due to their relatively low concentrations are the so called free forms. The free forms of all the hormones (shown in Figs. 1–3) are the hormones not bound to proteins, or conjugated to other...
Sex hormones like estrogen and testosterone don’t just affect things like body shape or voice—they also play a role in how the immune system works. This is especially important for transgender people who take these hormones as part of their...
Download slides (from my book "Beyond Testosterone"): Estradiol in Men Slides Estradiol in Men: The Stigma In the 2014 film The Other Woman, Cameron Diaz, Leslie Mann, and Kate Upton, portray three jilted females who discover they are...
Managing the Testosterone-to-Estradiol Ratio in Men on TRT Introduction Testosterone replacement therapy (TRT) in hypogonadal men often leads to an increase in estradiol (E2) levels due to the aromatization of testosterone. This alters the...
