Is long term TRT a lifetime commitment?

Abonicex

Member
I've been seeing conflicting information regarding this. So searched around and I read a few threads that seems to indicate that for some people, normal testicular function is not restored after leaving TRT even after various months or years.

So, there's actually no guarantee that you will go back to normal after starting TRT? Is there any estimation of probabilities after certain years, age, etc?

I really want to start TRT, but an incoming future scarcity of medication makes me worried.

TY.
 
I haven't seen anything that answers this with great precision, but in general the shorter the time you are "on", the lower the dose, the younger you are, and the heathier you are, the more likely it is that you can get back to where you were, but those are just generalities. However as a practical matter:
1. Many men start with a low dose of Clomid to boost their natural production, and in a minority of cases that is sufficient to delay TRT for a few years.
2. Depending on your overall health, improvements you make while on TRT such as fat loss and improved conditioning could put you in a better state such that you would have a better outcome if you ever had to come off.
3. You should build a stockpile of any medication (or anything else) that you don't want to be without. Many of us had to do that with HCG recently. You should likely do this even if you do not go on TRT now since you might need to some years in the future.
4. Your current situation should likely be the biggest factor in your decision since worrying about what might happen could cause you to not address issues that have to be fixed no matter what.
5. If basic medications were unavailable for an extended period, your concerns would likely be on bigger issues, like food, water and societal breakdown, especially if you stocked up appropriately.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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