By Nelson Vergel | ExcelMale.com | Updated December 2025 Introduction Should you take an aromatase inhibitor with testosterone replacement therapy? This question has sparked considerable debate in men's health circles, with some clinics routinely...
The Libido Misconception For most men, a lagging sex drive triggers an immediate, single-minded thought: "It must be my testosterone." While T is a key player in male vitality, this assumption often misses the mark entirely. Libido is far more...
By Nelson Vergel | ExcelMale.com | Updated December 2025 Summary: This comprehensive guide examines the development of FDA-approved oral testosterone products—Jatenzo, Tlando, and Kyzatrex—which overcome the liver toxicity problems of earlier...
Many men begin testosterone replacement therapy expecting their sexual function to improve across the board—better libido, stronger erections, enhanced satisfaction. And while TRT often delivers significant benefits for desire and overall sexual...
Summary: The TRAVERSE trial, a landmark FDA-mandated study involving over 5,200 men, has definitively concluded that testosterone replacement therapy (TRT) does not increase the risk of major cardiovascular events like heart attacks, strokes, or...
SUMMARY: This comprehensive article examines the combination of testosterone replacement therapy (TRT) with GLP-1 medications like semaglutide and tirzepatide for men managing both low testosterone and obesity or type 2 diabetes. Research...
This nationwide study examines the prevalence of testosterone deficiency and the subsequent use of replacement therapy among men living with HIV. By analyzing data from over 100 million patients, researchers discovered that healthcare providers...
Clascoterone 5% Topical Solution for Male Androgenetic Alopecia Overview Clascoterone 5% topical solution represents what could be the first genuinely novel therapeutic mechanism for male pattern hair loss in over three decades. Cosmo...
How Much Testosterone Are You Actually Getting From Your TRT Protocol? If you're on testosterone replacement therapy (TRT), you've probably used a steroid calculator or plotter to visualize your dosing protocol. But here's a critical question...
FDA Approval of Testosterone Therapy for Women: An Analysis of Historical Failures, Regulatory Hurdles, and a Path Forward Executive Summary The landscape of testosterone therapy presents a stark gender disparity: while over 31 FDA-approved...
Melatonin's Role in Reproductive Health and Fertility Executive Summary Melatonin (N-acetyl-5-methoxytryptamine), a neurohormone primarily known for regulating circadian rhythms, demonstrates profound and multifaceted effects on male and female...
I collected questions and answers posted on ExcelMale.com in the last 10 years about the use of human chorionic gonadotropin in men who want to prevent loss of testicular size and fertility while on testosterone replacement therapy or that want...
