Sleeping much better on Kyzatrex vs injections

[albert88]

Thank you for the great information but if I can ask, was sleep the only reason you stopped TRT? Did you experience any other sides that led to your decision?

Excellent question and I'll tell you up-front, it was a difficult decision because TRT came to my rescue when I was super stressed out, going through a divorce, losing my edge and drive, etc. etc...

Yes, main reason I stopped was for better sleep. I've optimized just about everything else and the last loose screw was the T. I had to accept the fact that prior to TRT, I would get at minimum "okay" sleep where I'd wake up and be ready to go most of the time. On TRT, I'd randomly get good sleep but most of it was lower quality and I felt the thing that was sustaining me was the hormone, not actual deep recovery through sleep. And, sleep apnea creeped in as well on TRT (light to mild, but enough to mess with REM).

I also had a few other negative affects like loss of sensitivity down there, huge reduction in semen...these have already come back.

The other thing, and this may sound funny...I felt like whatever hormones got pushed down (LH? FSH? no idea...) it caused a loss of deep satisfaction of life. The satisfaction I had was more surface level. Hard to describe. Almost like comparing Dopamine vs. Serotonin. Dopamine may have gone up, but actual satisfaction comes from Serotonin, which I felt like was driven down.

Mid-September will be 3 months off TRT, with no protocol to re-start. I am 100% feeling better (for now), am keeping even more active compared to being on TRT, controlling my food intake even better, and my sleep is clearly improving (my Whoop tracker's AI system confirms this with certainty). Let's see how months 3-6 go.

 

[ajallday]

Excellent question and I'll tell you up-front, it was a difficult decision because TRT came to my rescue when I was super stressed out, going through a divorce, losing my edge and drive, etc. etc...

Yes, main reason I stopped was for better sleep. I've optimized just about everything else and the last loose screw was the T. I had to accept the fact that prior to TRT, I would get at minimum "okay" sleep where I'd wake up and be ready to go most of the time. On TRT, I'd randomly get good sleep but most of it was lower quality and I felt the thing that was sustaining me was the hormone, not actual deep recovery through sleep. And, sleep apnea creeped in as well on TRT (light to mild, but enough to mess with REM).

I also had a few other negative affects like loss of sensitivity down there, huge reduction in semen...these have already come back.

The other thing, and this may sound funny...I felt like whatever hormones got pushed down (LH? FSH? no idea...) it caused a loss of deep satisfaction of life. The satisfaction I had was more surface level. Hard to describe. Almost like comparing Dopamine vs. Serotonin. Dopamine may have gone up, but actual satisfaction comes from Serotonin, which I felt like was driven down.

Mid-September will be 3 months off TRT, with no protocol to re-start. I am 100% feeling better (for now), am keeping even more active compared to being on TRT, controlling my food intake even better, and my sleep is clearly improving (my Whoop tracker's AI system confirms this with certainty). Let's see how months 3-6 go.

Great response, thank you.

 

[Vman]

Update with latest labs on lowered dose of Kyzatrex.

Cut daily dose to 150mg of Kyzatrex at breakfast and lunch starting on 8/26/2026.

Labs on 10/19/2026 @3pm (3.5 hours post lunch dose, 150mg BID):
Total T: 683 (250-1100 ng/dL)
Free T: 155.3 (35-155 pg/mL)
SHBG: 25 (10-50 nmol/L)
Hemoglobin: 15.9 (13.2-17.1 g/dL)
Hematocrit: 47.5 (39.4-51.1 %)
Ferritin: 84 (38-380 ng/mL)

Labs on 8/4/2026 @ 8:54am (before morning 200mg Kyzatrex dose):
Total T: 55 (250-1100 ng/dL)
Free T: 10.7 (35-155 pg/mL)

Labs on 6/2/2026 @ 3pm (3.5 hours post lunch dose, 200mg BID):
Total T: 1887 (250-1100 ng/dL)
Free T: 445.3 (35-155 pg/mL)

So Kyzatrex has fixed everything that I was hoping it would vs. injections! It took 7 months and some dose adjustments but my HCT, HGB and ferritin are normal now. I haven't seen those results be green on my labs since I started TRT 8 years ago! And I got the bonus of sleeping like a baby. My workouts, energy, libido are all great.

Since I have room in my labs, I'm going to try going back to 200mg 2xdaily to see if my HCT, HGB and ferritin stay low. Always trying for the highest TT/FT I can get without side effects!

 

[madman]

Update with latest labs on lowered dose of Kyzatrex.

Cut daily dose to 150mg of Kyzatrex at breakfast and lunch starting on 8/26/2026.

Labs on 10/19/2026 @3pm (3.5 hours post lunch dose, 150mg BID):
Total T: 683 (250-1100 ng/dL)
Free T: 155.3 (35-155 pg/mL)
SHBG: 25 (10-50 nmol/L)
Hemoglobin: 15.9 (13.2-17.1 g/dL)
Hematocrit: 47.5 (39.4-51.1 %)
Ferritin: 84 (38-380 ng/mL)

Labs on 8/4/2026 @ 8:54am (before morning 200mg Kyzatrex dose):
Total T: 55 (250-1100 ng/dL)
Free T: 10.7 (35-155 pg/mL)

Labs on 6/2/2026 @ 3pm (3.5 hours post lunch dose, 200mg BID):
Total T: 1887 (250-1100 ng/dL)
Free T: 445.3 (35-155 pg/mL)

So Kyzatrex has fixed everything that I was hoping it would vs. injections! It took 7 months and some dose adjustments but my HCT, HGB and ferritin are normal now. I haven't seen those results be green on my labs since I started TRT 8 years ago! And I got the bonus of sleeping like a baby. My workouts, energy, libido are all great.

Since I have room in my labs, I'm going to try going back to 200mg 2xdaily to see if my HCT, HGB and ferritin stay low. Always trying for the highest TT/FT I can get without side effects!

Cut daily dose to 150mg of Kyzatrex at breakfast and lunch starting on 8/26/2026.

Labs on 10/19/2026 @3pm (3.5 hours post lunch dose, 150mg BID):
Total T: 683 (250-1100 ng/dL)
Free T: 155.3 (35-155 pg/mL)
SHBG: 25 (10-50 nmol/L)
Hemoglobin: 15.9 (13.2-17.1 g/dL)
Hematocrit: 47.5 (39.4-51.1 %)
Ferritin: 84 (38-380 ng/mL)


Was just a matter of time before the H/H came down especially seeing as there is a huge difference in your peak TT 683 ng/dL and more importantly FT 15.5 ng/dL on 150 mg BID hybrid protocol (morning/noon) vs your absurdly high peak TT 1887 ng/dL and very high FT 44.5 ng/dL on 200 mg BID hybrid protocol (morning/noon) mind you your true trough (lowest point) before your next dose (morning) was much lower yet your hemoglobin and hematocrit were still high.

Your true trough on your current dose would be really low as your peak TT and more importantly FT are not that high!

This is why your hematocrit came down.

As I pointed out previously the peak TT/FT would be short-lived when following a standard dosing protocol (morning/evening).

The standard dosing protocol allows one to take advantage of 2 short-lived peaks with no overlap and T levels will be back or close to baseline 8-12 hrs post-dose which is advantageous to having minimal impact on driving up the hematocrit.

When following the hybrid protocol (morning/noon) your high TT and more importantly FT will be sustained longer throughout the day vs the standard protocol (early am/evening) dosed 12 hrs apart even though your trough would still end up lower on your hybrid protocol.

Yes you easily have room to bring up your peak TT/FT within reason as you are hitting a robust peak 683 ng/dL which is not that high and more importantly a healthy peak FT 15.5 ng/dL which is not that high.

Still need to tread lightly here and the more sensible move would be aiming for a peak 20-30 ng/dL vs the very high peak FT 44.5 ng/dL you were hitting on your 200 mg BID hybrid protocol as your hemoglobin and hematocrit were still high even though your trough was low.

If you bump your dose back up to 200 mg BID chances are you are going to still end up driving up the hematocrit due to achieving a high TT and more importantly FT which will be sustained longer throughout the day vs a standard dosing protocol even if your trough is still much lower.

Next time round test your peak TT/FT and trough on the same day or week as oppose to waiting two months.

Need to stop getting caught up on that more T is better mentality nonsense too.

The goal is not aiming for the highest TT/FT.

It would be aiming for healthy T levels within reason while at the same time minimizing/avoiding sides and keeping blood markers healthy long-term keeping in mind we are on T therapy here and the overall goal is to achieve robust youthful levels which will relieve/improve symptoms and overall well-being.

 

[Vman]

Cut daily dose to 150mg of Kyzatrex at breakfast and lunch starting on 8/26/2026.

Labs on 10/19/2026 @3pm (3.5 hours post lunch dose, 150mg BID):
Total T: 683 (250-1100 ng/dL)
Free T: 155.3 (35-155 pg/mL)
SHBG: 25 (10-50 nmol/L)
Hemoglobin: 15.9 (13.2-17.1 g/dL)
Hematocrit: 47.5 (39.4-51.1 %)
Ferritin: 84 (38-380 ng/mL)


Was just a matter of time before the H/H came down especially seeing as there is a huge difference in your peak TT 683 ng/dL and more importantly FT 15.5 ng/dL on 150 mg BID hybrid protocol (morning/noon) vs your absurdly high peak TT 1887 ng/dL and very high FT 44.5 ng/dL on 200 mg BID hybrid protocol (morning/noon) mind you your true trough (lowest point) before your next dose (morning) was much lower yet your hemoglobin and hematocrit were still high.

Your true trough on your current dose would be really low as your peak TT and more importantly FT are not that high!

This is why your hematocrit came down.

As I pointed out previously the peak TT/FT would be short-lived when following a standard dosing protocol (morning/evening).

The standard dosing protocol allows one to take advantage of 2 short-lived peaks with no overlap and T levels will be back or close to baseline 8-12 hrs post-dose which is advantageous to having minimal impact on driving up the hematocrit.

When following the hybrid protocol (morning/noon) your high TT and more importantly FT will be sustained longer throughout the day vs the standard protocol (early am/evening) dosed 12 hrs apart even though your trough would still end up lower on your hybrid protocol.

Yes you easily have room to bring up your peak TT/FT within reason as you are hitting a robust peak 683 ng/dL which is not that high and more importantly a healthy peak FT 15.5 ng/dL which is not that high.

Still need to tread lightly here and the more sensible move would be aiming for a peak 20-30 ng/dL vs the very high peak FT 44.5 ng/dL you were hitting on your 200 mg BID hybrid protocol as your hemoglobin and hematocrit were still high even though your trough was low.

If you bump your dose back up to 200 mg BID chances are you are going to still end up driving up the hematocrit due to achieving a high TT and more importantly FT which will be sustained longer throughout the day vs a standard dosing protocol even if your trough is still much lower.

Next time round test your peak TT/FT and trough on the same day or week as oppose to waiting two months.

Need to stop getting caught up on that more T is better mentality nonsense too.

The goal is not aiming for the highest TT/FT.

It would be aiming for healthy T levels within reason while at the same time minimizing/avoiding sides and keeping blood markers healthy long-term keeping in mind we are on T therapy here and the overall goal is to achieve robust youthful levels which will relieve/improve symptoms and overall well-being.

Thanks for your feedback on my labs and next steps @madman. It's always greatly appreciated!

I would definitely try a 175mg Kyzatrex if one existed. Sadly, it doesn't. They actually discontinued their 100mg (no one could achieve healthy TT/FT on it), so now they only offer a 150mg and 200mg. It looks like they now offer a 50mg dose that I could freeze and cut it in half along with a 150mg to get 175mg. Maybe that is an option I could try though it'd be pretty inconvenient. Another thing I could try is a 200mg morning and 150mg lunch dose.

My thinking on trying the 200mg BID again is that I was not on it that long and my H/H were still heading lower. So I'm not sure how much of the decrease in my H/H is due to the amount of time I have been on Kyzatrex vs. the lower 150mg BID dose. If my HCT stays below 54 on 200mg BID without blood donations and I have no other side effects then I'll probably stay at 200mg BID. Otherwise, I'll either go back to 150mg BID or explore the other options I already mentioned.

 

[madman]

Thanks for your feedback on my labs and next steps @madman. It's always greatly appreciated!

I would definitely try a 175mg Kyzatrex if one existed. Sadly, it doesn't. They actually discontinued their 100mg (no one could achieve healthy TT/FT on it), so now they only offer a 150mg and 200mg. It looks like they now offer a 50mg dose that I could freeze and cut it in half along with a 150mg to get 175mg. Maybe that is an option I could try though it'd be pretty inconvenient. Another thing I could try is a 200mg morning and 150mg lunch dose.

My thinking on trying the 200mg BID again is that I was not on it that long and my H/H were still heading lower. So I'm not sure how much of the decrease in my H/H is due to the amount of time I have been on Kyzatrex vs. the lower 150mg BID dose. If my HCT stays below 54 on 200mg BID without blood donations and I have no other side effects then I'll probably stay at 200mg BID. Otherwise, I'll either go back to 150mg BID or explore the other options I already mentioned.

Do what you feel is best for you.

If you want to give the 200 mg BID dose a go then just make sure you give it 3 months before testing your H/H and ferritin.

If things go south then you have other options.