Is proviron (mesterolone) a viable alternative to aromatase inhibitors for managing estrogen on testosterone replacement therapy? This controversial thread examines the use of proviron, a DHT-derivative oral steroid that has been prescribed in European TRT protocols for decades but remains rarely used in American men's health clinics. Proponents argue that proviron offers unique benefits beyond simple estrogen management—enhancing libido, improving mood through potential anti-depressant effects, and increasing free testosterone by displacing it from SHBG binding. Research shows proviron has been successfully used to treat male infertility and depression in clinical settings, though critics note its low 3% bioavailability and rapid inactivation in skeletal muscle tissue make it a "weak" compound compared to other DHT derivatives like masteron or primobolan. The thread debates whether proviron's anti-estrogenic effects come from direct aromatase inhibition, competitive receptor binding, or SHBG reduction, with experienced users warning that even doses as low as 12.5-25 mg daily can produce symptoms of crashed estradiol in men on TRT. Forum members emphasize that proviron's legal status varies significantly by country, making it unavailable or difficult to obtain in many regions where more modern estrogen management strategies are preferred.
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Any thoughts on this? I’ve been reading that it is better to lower estrogen than anastrozole on trt...
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Any thoughts on this? I’ve been reading that it is better to lower estrogen than anastrozole on trt...
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