Latest labs. Would appreciate any input on next steps...thank you!

RP McMurphy

New Member
I'm a 46 yo male, 150lb, 5' 6", been on TRT on/off for almost 3 years. After trying 6 months off of TRT (not fun), I restarted at a lower dose of 16mg every other day subq of cypionate/propionate blend (160/40/mg/ml).

Previously I was dosing 20mg every other day, but had elevated hematocrit of 50.3, hemoglobin 17, estradiol ultra sensitive 52, DHT 56, and an increase in BP and resting heart rate, so I thought I’d experiment with lowering the dose. Note that free T was at the top high end of range on earlier dose of 20mg eod.

Current labs after 2 months on TRT dose of 16mg EOD.
(
Note that I am also taking 30mg armour, 150mg pregnenolone)

Total T (MS) 643 ng/dL
Free T 35-155 pg/ml dialysis 83.1
Estradiol ultrasensitive <=29 43 H
Hemoglobin 13.2-17.1 g/dL 17.1 H
Hematocrit 38.5-50% 50.8 H
DHT 12-65 ng/dL LC/MS 66 H
SHBG 10-50 nmol/L. 52 H
Prolactin 2-18 ng/ml 7.1
Pregnenolone 22-236 ng/dL 200 (likely on higher end becasue I dosed the night before lab draw)
Progesterone <1.4 ng/ml 2.7 H

I’m surprised at some of these high lab values on such a low dose of TRT. I’d prefer to see my Free T higher in the range as when it was higher I noticed a better response in the gym. It's interesting to me to see that some of these high values actually looked better when I was dosing slightly higher....potentially other inputs at play who knows.

Some options I’m considering:
-Try anavar (oxandrolone) troche 10mg 3x/wk to lower SHBG (per Dr. Peter Attia)
-Going back to increased dose of 20mg EOD and introduce AI .1mg 2-3x/wk
-Donate blood regularly to lower hematocrit/hemoglobin

What am I missing? Any input would be greatly appreciated.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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