Anyone have success with HCG/Clomid?

[MJ65]

Seeking feedback if anyone has had any success with HCG mono therapy or HCG/Clomid combo therapy for low T. I’m not worried about fertility. My doctor has recommended this as an option.
I have issues with high RBC, H&H and low ferritin on testosterone have tried, injections, transdermal and oral and have the same issue on all. Over 1 year since I have tried testosterone. Looking for other options if possible

60 year old male,
LH 1.9, FSH 5.9
SHBG 38
Total T 423
Free T 53
E2 18
Prolactin 6.3
All values per Quest Labs

 

[Nelson Vergel]

B

Thread 'HCG + Clomid or HCG only ?'

Dec 3, 2025

I am 46 years old and I`ve been on TRT for around 7 years.
I decided to try and stop TRT because It has been mostly ok but I struggle with libido and sensitivity down there as well as difficulty ejaculating and reaching orgasm although my testosterone was quite OK between always between 700 - 900. Tried TRT with and without AI although my E2 was never alarmingly high just based on these symptoms and sometimes some niple sensitivity and pain but without ginecomastia. I used anastrazol 0,25 gm twice per week first continually and later on demand. Sometimes it seemed to help sometimes it...

• Bolex
• hcg trt
• Replies: 9
• Forum: hCG, Clomid & Others for Fertility, PCT or Low T

Thread 'Evaluating the Combination of hCG + Clomid in Treatment of Male Hypogonadism'

Jun 19, 2021

Background: In this study, we evaluated MHH patients who wished to preserve fertility, assessing the efficacy of a short course (12 months) of a combined hCG +clomiphene citrate.

Materials and Methods: The cross-sectional study included 19 patients with hypogonadotropic hypogonadism who were admitted to the Andrology and Fertility Hospital of Hanoi between March 2016 and March 2018. Using hCG every three days in combination with clomiphene citrate 25mg per day until normal testosterone levels are reached, maintain the dose until spermatozoa are present.

Results: The...

• madman
• clomid + hcg/hypogonadism; fertility
• Replies: 12
• Forum: hCG, Clomid & Others for Fertility, PCT or Low T

Thread '50 mg/day Clomid (Clomiphene) plus High Dose HCG Study in Men'

Oct 6, 2018

Clomiphene citrate and human chorionic gonadotropin are both effective in restoring testosterone in hypogonadism: a short‐course randomized study


Objectives


To compare serum testosterone response and symptom improvement in men with hypogonadism in response to treatment with clomiphene citrate (CC), human chorionic gonadotropin (hCG), or a combination of both therapies.

Patients and Methods
A total of 282 men with hypogonadism, wishing to preserve their fertility, were randomized to one of three treatment arms: CC 50 mg (n=...

• Nelson Vergel
• clomid plus hcg clomiphene plus hcg hcg
• Replies: 7
• Forum: hCG, Clomid & Others for Fertility, PCT or Low T

 

[MJ65]

B

Thread 'HCG + Clomid or HCG only ?'

Dec 3, 2025

I am 46 years old and I`ve been on TRT for around 7 years.
I decided to try and stop TRT because It has been mostly ok but I struggle with libido and sensitivity down there as well as difficulty ejaculating and reaching orgasm although my testosterone was quite OK between always between 700 - 900. Tried TRT with and without AI although my E2 was never alarmingly high just based on these symptoms and sometimes some niple sensitivity and pain but without ginecomastia. I used anastrazol 0,25 gm twice per week first continually and later on demand. Sometimes it seemed to help sometimes it...

• Bolex
• hcg trt
• Replies: 9
• Forum: hCG, Clomid & Others for Fertility, PCT or Low T

Thread 'Evaluating the Combination of hCG + Clomid in Treatment of Male Hypogonadism'

Jun 19, 2021

Background: In this study, we evaluated MHH patients who wished to preserve fertility, assessing the efficacy of a short course (12 months) of a combined hCG +clomiphene citrate.

Materials and Methods: The cross-sectional study included 19 patients with hypogonadotropic hypogonadism who were admitted to the Andrology and Fertility Hospital of Hanoi between March 2016 and March 2018. Using hCG every three days in combination with clomiphene citrate 25mg per day until normal testosterone levels are reached, maintain the dose until spermatozoa are present.

Results: The...

• madman
• clomid + hcg/hypogonadism; fertility
• Replies: 12
• Forum: hCG, Clomid & Others for Fertility, PCT or Low T

Thread '50 mg/day Clomid (Clomiphene) plus High Dose HCG Study in Men'

Oct 6, 2018

Clomiphene citrate and human chorionic gonadotropin are both effective in restoring testosterone in hypogonadism: a short‐course randomized study


Objectives


To compare serum testosterone response and symptom improvement in men with hypogonadism in response to treatment with clomiphene citrate (CC), human chorionic gonadotropin (hCG), or a combination of both therapies.

Patients and Methods
A total of 282 men with hypogonadism, wishing to preserve their fertility, were randomized to one of three treatment arms: CC 50 mg (n=...

• Nelson Vergel
• clomid plus hcg clomiphene plus hcg hcg
• Replies: 7
• Forum: hCG, Clomid & Others for Fertility, PCT or Low T

Thank you Nelson. I don't post often but you are very helpful as usual.

 

[Nelson Vergel]

Thank you Nelson. I don't post often but you are very helpful as usual.

You are welcome. Feel free to ask anything even if it has been discussed before.

We are all here to help each other.

At 67 and as I become older, I realize that I would never let go of this forum. Not only we all help each other, but I learn something new almost every day. We have such smart guys here that are laser-focused on health. I feel that ExcelMale has given me a chance to interact with fellow health geeks that I have never have had the pleasure to meet in person, and yet I have learned something new almost much from them. Too bad my world in “real time “ does not present the opportunity to hang out personally with guys on ExcelMale who are spread out around the world.

 

[Stoak]

I run HCG monotherapy for a month twice per year as a reset on TRT. I feel pretty good on 1000iu MWF. I would never take Clomid indefinitely and would personally try the HCG only first. What is his suggested dose?

 

[MJ65]

I run HCG monotherapy for a month twice per year as a reset on TRT. I feel pretty good on 1000iu MWF. I would never take Clomid indefinitely and would personally try the HCG only first. What is his suggested dose?

My doctor is suggesting 500iu 2x week to start and titrate as needed with 25mg Clomid 1xday. I am not sure about the Clomid dose.

 

[Stoak]

My doctor is suggesting 500iu 2x week to start and titrate as needed with 25mg Clomid 1xday. I am not sure about the Clomid dose.

My guess is that the HCG dose would be far to low and the clomid will cause it's own problems that don't show in the numbers.

 

[Guided_by_Voices]

I would think another option is to start with Clomid (or enclomiphene) only first. I had success with that for a year or two when I first started. If that doesn't work then switching to HCG, which mimics the LH which clomid is trying to increase seems like the next step. Trying to run them together seems like unnecessary complexity especially since they tend to oppose each other at the Hypothalamus.

 

[MJ65]

I would think another option is to start with Clomid (or enclomiphene) only first. I had success with that for a year or two when I first started. If that doesn't work then switching to HCG, which mimics the LH which clomid is trying to increase seems like the next step. Trying to run them together seems like unnecessary complexity especially since they tend to oppose each other at the Hypothalamus.

Thanks, I appreciate the suggestions. I have been diagnosed as secondary hypgonadism as my LH is low at 1.9 due to weak pituitary signaling. While my total test is not great at 422 it is not horrible for my age. My Free T is extremely low at 53 which could be driving my symptoms. I am hoping one of these options work as testosterone replacement is not an option at this point due to previously mentioned issues