KYZATREX® Safe for your liver: Lymphatic Absorption

madman · Oct 12, 2025

* The good news is that KYZATREX was specifically designed to be absorbed lymphatically. This means it bypasses your liver avoiding the liver toxicity associated with oral testosterone medications of the past.

Kyzatrex® (testosterone undecanoate) an oral testosterone therapy

Taken twice daily with food ideally a meal with some healthy fats

Foods with healthy fats help the body absorb the medicine, after swallowing the Kyzatrex® capsule dissolves in the digestive system and releases its active ingredients

Kyzatrex® is not like oral methylltestosterone which passes through the liver and can increase the risk of serious liver problems, Kyzatrex® instead is absorbed through the intestines and carried into the lymphatic system, from there it moves into the bloodstream efficiently helping deliver testosterone where its needed

Thread 'Predicting Intestinal and Hepatic First-Pass Metabolism of Orally Administered TU'

Nov 5, 2020

https://www.mdpi.com/2076-3417/10/20/7283#:~:text=Accordingly%2C%20only%2011%25%20of%20the,metabolised%20during%20first%2Dpass%20effect.

Abstract

The bioavailability of orally administered drugs could be impacted by intestinal and hepatic first-pass metabolism. Testosterone undecanoate (TU), an orally administered ester prodrug of testosterone, is significantly subjected to the first-pass metabolism. However, the individual contribution of intestinal and hepatic first-pass metabolism is not well determined. Therefore, the aim of the current study was to...

madman · Oct 12, 2025

Thread 'Newer formulations of oral testosterone: development and liver side effects'

Sep 19, 2024

Abstract

Introduction

Testosterone deficiency is a clinical disorder due to either failure of the testes to produce testosterone or failure of the hypothalamus or pituitary to produce sufficient gonadotropins. Previous formulations of oral testosterone therapy, particularly methyltestosterone,have been associated with adverse liver effects. Many different routes of testosterone delivery have been developed, each with their own administrative benefits and challenges. Newer formulations of oral testosterone undecanoate (TU) provide a convenient administration option, although...

madman · Oct 12, 2025

Post in thread 'FDA-Approved Oral Testosterone: Jatenzo (Testosterone Undecanoate)'

Sep 6, 2022

goga said:
Is Jatenzo considered to be safe for liver? As I know, there were some issues with Andriol.

Yes.

post #4

thoughts on a gel for me - Excel Male Health Forum

I have tried testosterone on and off over the years but I never stick with it. I first tried the self injections but a couple times hit a muscle and was sore for a week so I gave up on them. Then I tried the under the tongue trocees (or however you spell it) they took forever to dissolve that...

www.excelmale.com

SAFETY ANALYSIS OF AN ORAL TESTOSTERONE UNDECANOATE (TU) FORMULATION FOLLOWING 2 YEARS OF ADMINISTRATION IN HYPOGONADAL MEN (2021)

CONCLUSIONS: This oral TU formulation is an option for hypogonadal men and has a safety profile consistent with other approved T products. Notably, no...

madman · Oct 12, 2025

Post in thread 'Oral TU - Safety/Efficacy'

Jun 22, 2024

Table 3. Liver function tests following two-years of oral testosterone undecanoate (TU)

Thread 'Oral TU offers a safe and effective long-term treatment option for men with hypogonadism'

Nov 10, 2022

Two-Year Analysis of a New Oral Testosterone Undecanoate (TU) Formulation in Hypogonadal Men: Efficacy, Impact on Psychosexual Function, and Safety (2022)
Stanton Honig, MD, Marc Gittelman, MD, Jed Kaminetsky, MD, Christina Wang, MD, John K. Amory, MD, Nestor Rohowsky, MA, Robert E. Dudley, Ph.D., B. Woun Seo, Ph.D, Jay Newmark, MD, and Ronald Swerdloff, MD

ABSTRACT

Background: Long-term data evaluating the efficacy and safety of oral testosterone undecanoate (oral TU; JATENZO) in adult hypogonadal men provides important information for healthcare professionals who...

madman · Oct 12, 2025

Thread 'KYZATREX® - A NEW ORAL TESTOSTERONE & Why It's Better Than Injections'

Sep 3, 2025

Show notes:

(0:00) Intro
(1:01) The 13-year FDA journey and breaking stigmas
(4:09) Why it’s different from other oral testosterone
(6:12) Mimicking the body’s natural testosterone rhythm
(9:10) Estrogen balance, side effects, and fertility concerns
(13:51) Testosterone’s role in women’s health
(16:56) Free vs total testosterone and SHBG reduction
(24:08) Testosterone vs weight loss drugs
(29:55) Who should be cautious with testosterone therapy
(35:46) What counts as low...

Thread 'KYZATREX (oral testosterone undecanoate) Updates'

Oct 16, 2022

KYZATREX™ (testosterone undecanoate capsules)

The Power of Hormonal Balance | Restore your T- levels with Two KYZATREX capsules a day. | Discover KYZATREX Rediscover CONFIDENCE | A solution sans needles, gels, or creams

www.kyzatrex.com

KYZATREX (testosterone undecanoate) is an oral testosterone replacement therapy specifically designed for adult males with conditions associated with a deficiency or absence of endogenous testosterone, such as primary hypogonadism and hypogonadotropic hypogonadism 11 12. Here is detailed information regarding its dosage, usage, side effects, price, and efficacy:

Dosage

KYZATREX is available in capsule form in three dosage strengths: 100 mg, 150 mg, and 200 mg. The recommended starting dose is 200 mg...

Thread 'Shifting the Testosterone Treatment Paradigm with Oral Testosterone (Kyzatrex)'

Apr 18, 2025

Again you heard it here first!

Nelson's domain the one and only!

Very informative webinar on the use of the newer oral TU formulations.

Testosterone therapy has long been dominated by injectable and topical formulations, but the landscape is evolving. This webinar explores how oral testosterone is redefining treatment protocols, offering a convenient and effective alternative. With recent clinical insights and real-world data, we’ll discuss why practitioners should reconsider their approach to testosterone replacement therapy (TRT)....

post #10 (Go nuts!)

Post in thread 'Oral Testosterone Therapy in Men with Low Testosterone: A Comprehensive Review'

Nov 17, 2024

STACKED

Testosterone and Men's Hormone Health - Excel Male Health Forum

Dr. Jared Pelo interviews our advisor Andrew Y. Sun on men's hormone health and the nuances of testosterone replacement. This video goes into types of testosterone replacement and the positive benefits of utilizing this medical treatment. Do you have these questions? - What are the...

www.excelmale.com

Titratable Oral TU (Jatenzo) Achieved Similar Testosterone Levels Across BMI Subgroups - Excel Male Health Forum

* Overall, oral TU achieved similar T levels across BMI subgroups with higher BMI patients utilizing higher doses. Men may likely require different T doses based on factors such as BMI to achieve effective levels. https://www.androgensociety.org/images/Annual2024/2024-Abstracts.pdf...

www.excelmale.com

High-Dose Oral TU Kyzatrex in Men with Low Testosterone: Safety, Efficacy, and Patient Satisfaction - Excel Male Health Forum

Hot off the press! You heard it here first, Nelson's domain is where it's at! High-dosed oral TU (Kyzatrex 400 mg) BID, LH/FSH while lower were maintained at non-zero levels, minimal impact on hematocrit! *At a mean follow up time of 6 months, patients demonstrated a significant...

www.excelmale.com

Oral TU Quickly and Effectively Achieves Serum Testosterone ≥300 NG/DL in Most Hypogonadal Men Without Dose Titrations - Excel Male Health Forum

* Overall, the starting dose of 237 mg TU BID quickly and effectively increased serum T concentrations ≥300 ng/dL in 85% of hypogonadal men. The wide distribution of serum T concentrations for the same dose (e.g., 15% <300 ng/d and 12% ≥1000 ng/dL) suggests that men likely respond differently...

www.excelmale.com

...

madman · Oct 12, 2025

Post in thread 'Breaking New Ground in Men's Health: Oral Testosterone (Kyzatrex)'

Feb 7, 2025

molonlabedoc said:
How does this differ from Jetenzo?

Nothing worth fretting over!

All of the oral T formulations use testosterone undecanoate in castor oil and the PKs are similar.

Other than the older oral TU Andriol which was dosed 2-3 times daily all of the newer oral TU formulations (Jatenzo, Tlando and Kyzatrex) are dosed twice daily (am/pm) which will result in 2 daily peaks/troughs.

Starting dose and strength of capsules differ between formulations.

The older oral TU Andriol had to be taken with a high fat meal to improve absorption/bioavailability whereas the newer oral TU formulations...

madman · Oct 12, 2025

Pros/Cons oral TU (51:24-57:12)

* one of the things that the orals have transformed is the concept that you have to have a continually high level of testosterone to get the benefits and clearly that's not true and the safety profile seems to be improved by having levels that fluctuate some during the day returning to close to or even baseline

Thread 'Testosterone Therapy Today: Clinical Advances & Safety with Dr. Abraham Morgentaler'

Sep 16, 2024

Dr. Morgentaler back in action!

Listen closely, loved this one!

Pros/Cons oral TU (51:24-57:12)

* one of the things that the orals have transformed is the concept that you have to have a continually high level of testosterone to get the benefits and clearly that's not true and the safety profile seems to be improved by having levels that fluctuate some during the day returning to close to or even baseline

Synopsis

Dr. Morgentaler starts by sharing his pioneering journey with testosterone...

madman · Oct 26, 2025

Thread 'Testosterone Breakthrough: A New Testosterone Solution Rocking the HRT World'

Oct 26, 2025

48:03: How to prescribe and access Kyzatrex

How to Prescribe

Through selected compounding and mail-order pharmacies, not at chain stores (CVS/Walgreens), keeping costs low and access high. Prescriptions are cash pay but often below compounding pharmacy prices—no insurance required.

Another perfect example of clinics dishing out those absurd 200 mg T/week protocols!

Still clueless!

26:15-36:52

elevated hematocrit/estradiol

* I see this more in men than in women because of the doses that we are giving them, so lets take the injectable...

madman · Nov 11, 2025

Thread 'The Testosterone Revolution: Affordable Oral TRT, Enclomiphene, and Personalized Low T Care'

Sep 10, 2025

* Starting today, providers will be able to prescribe tailored doses of compounded enclomiphene4 through the Hims & Hers platform and, for men experiencing sexual symptoms, offer personalized testosterone care that combines enclomiphene with tadalafil in a single dual-action treatment.

* Starting in 2026, that will include an exclusive branded oral testosterone (KYZATREX®) through a major health platform exclusive collaboration with Marius Pharmaceuticals.

https://www.hims.com/testosterone

...

madman · Nov 15, 2025

Thread 'What is the risk of liver toxicity with KYZATREX®'

Nov 15, 2025

ANDREW Y. SUN, MD,
UROLOGIST

madman · Nov 15, 2025

Thread 'What is the Optimal Lab Timing for Patients Taking KYZATREX®?'

Nov 15, 2025

ANDREW Y. SUN, MD
UROLOGIST

Peak T level (Tmax (≈3-5 hrs) post-dose administration

madman · Nov 15, 2025

Thread 'What are the Expected Changes in Free Testosterone and SHBG With KYZATREX®?'

Nov 15, 2025

ANDREW Y. SUN, MD
UROLOGIST

2X Increase of Mean Free Testosterone

30% Reduction of Mean SHBG

madman · Dec 20, 2025

Thread 'Guidance on the use of oral TU : background, clinical considerations, and best practices'

Dec 20, 2025

When it comes to elevated hematocrit everyone is still so caught up on peak T levels!

As I have been preaching for years on here running too high a trough/steady-state FT will have a big impact here!

* While the precise mechanism underlying secondary polycythemia in the setting of TTh is still debated, it is likely that a longer duration of supraphysiological testosterone levels drives erythrocytosis.

* Testosterone undecanoate (TU), developed in the 1970s, provided a solution by utilizing lymphatic absorption to bypass hepatic metabolism. The...

madman · Dec 24, 2025

Thread 'Treatment of Symptomatic Male Hypogonadism with New Oral Testosterone Therapies: A Comparative Review of Jatenzo, Tlando, and Kyzatrex'

Dec 24, 2025

https://www.mdpi.com/2305-6320/13/1/1#

Abstract

Symptomatic male hypogonadism, defined by low serum testosterone with associated clinical symptoms, is increasingly treated with testosterone replacement therapy. Traditional oral formulations were limited by hepatotoxicity and poor bioavailability, leading to reliance on injectable and transdermal routes. Recent advances in oral testosterone undecanoate formulations have introduced safer and more effective options. This review compares Jatenzo, Tlando, and Kyzatrex, highlighting their pharmacology, efficacy, safety, and...

madman · Dec 25, 2025

Thread 'JATENZO® Oral Testosterone Undecanoate - Efficacy, Flexible dosing and Safety Profile'

Dec 25, 2025

madman · Dec 25, 2025

Thread 'KEY TAKE-AWAYS ON REMOVAL OF BLACK BOX WARNING ON ADVERSE CV OUTCOMES FOR TESTOSTERONE THERAPY'

Dec 25, 2025

madman · Jan 3, 2026

Thread 'Oral TU Formulations (Andriol®, JATENZO®,TLANDO®, KYZATREX® for T Therapy'

Jan 3, 2026

* Oral TRT, particularly testosterone undecanoate (TU), offers notable convenience. TU is absorbed via the lymphatic system, bypassing first-pass hepatic metabolism, making it a promising agent for TRT. Its absorption, however, is influenced by dietary factors, such as lipid intake, thus the high-fat consumption promoting lymphatic absorption. Pharmaceutical technology developed TU formulations incorporate special self-emulsifying systems that enhance lymphatic absorption regardless of food fat content. This lymphatic absorption allows for stable testosterone levels...