KYZATREX® Safe for your liver: Lymphatic Absorption

madman · 2025-10-12T15:56:35-0500

* The good news is that KYZATREX was specifically designed to be absorbed lymphatically. This means it bypasses your liver avoiding the liver toxicity associated with oral testosterone medications of the past.

Kyzatrex® (testosterone undecanoate) an oral testosterone therapy

Taken twice daily with food ideally a meal with some healthy fats

Foods with healthy fats help the body absorb the medicine, after swallowing the Kyzatrex® capsule dissolves in the digestive system and releases its active ingredients

Kyzatrex® is not like oral methylltestosterone which passes through the liver and can increase the risk of serious liver problems, Kyzatrex® instead is absorbed through the intestines and carried into the lymphatic system, from there it moves into the bloodstream efficiently helping deliver testosterone where its needed

Thread 'Predicting Intestinal and Hepatic First-Pass Metabolism of Orally Administered TU'

Nov 5, 2020

Abstract: The bioavailability of orally administered drugs could be impacted by intestinal and hepatic first-pass metabolism. Testosterone undecanoate (TU), an orally administered ester prodrug of testosterone, is significantly subjected to the first-pass metabolism. However, the individual contribution of intestinal and hepatic first-pass metabolism is not well determined. Therefore, the aim of the current study was to predict the metabolic contribution of each site. The hydrolysis–time profiles of TU incubation in human liver microsomes and Caco-2 cell homogenate...

madman · 2025-10-12T15:59:07-0500

Thread 'Newer formulations of oral testosterone: development and liver side effects'

Sep 19, 2024

Abstract

Introduction

Testosterone deficiency is a clinical disorder due to either failure of the testes to produce testosterone or failure of the hypothalamus or pituitary to produce sufficient gonadotropins. Previous formulations of oral testosterone therapy, particularly methyltestosterone,have been associated with adverse liver effects. Many different routes of testosterone delivery have been developed, each with their own administrative benefits and challenges. Newer formulations of oral testosterone undecanoate (TU) provide a convenient administration option, although...

madman · 2025-10-12T16:02:26-0500

Post in thread 'FDA-Approved Oral Testosterone: Jatenzo (Testosterone Undecanoate)'

Sep 6, 2022

goga said:
Is Jatenzo considered to be safe for liver? As I know, there were some issues with Andriol.

Yes.

post #4

thoughts on a gel for me - Excel Male Health Forum

I have tried testosterone on and off over the years but I never stick with it. I first tried the self injections but a couple times hit a muscle and was sore for a week so I gave up on them. Then I tried the under the tongue trocees (or however you spell it) they took forever to dissolve that...

www.excelmale.com

SAFETY ANALYSIS OF AN ORAL TESTOSTERONE UNDECANOATE (TU) FORMULATION FOLLOWING 2 YEARS OF ADMINISTRATION IN HYPOGONADAL MEN (2021)

CONCLUSIONS: This oral TU formulation is an option for hypogonadal men and has a safety profile consistent with other approved T products. Notably, no...

madman · 2025-10-12T16:04:22-0500

Post in thread 'Oral TU - Safety/Efficacy'

Jun 22, 2024

Table 3. Liver function tests following two-years of oral testosterone undecanoate (TU)

Thread 'Oral TU offers a safe and effective long-term treatment option for men with hypogonadism'

Nov 10, 2022

Two-Year Analysis of a New Oral Testosterone Undecanoate (TU) Formulation in Hypogonadal Men: Efficacy, Impact on Psychosexual Function, and Safety (2022)
Stanton Honig, MD, Marc Gittelman, MD, Jed Kaminetsky, MD, Christina Wang, MD, John K. Amory, MD, Nestor Rohowsky, MA, Robert E. Dudley, Ph.D., B. Woun Seo, Ph.D, Jay Newmark, MD, and Ronald Swerdloff, MD

ABSTRACT

Background: Long-term data evaluating the efficacy and safety of oral testosterone undecanoate (oral TU; JATENZO) in adult hypogonadal men provides important information for healthcare professionals who...

madman · 2025-10-12T16:07:18-0500

Thread 'KYZATREX® - A NEW ORAL TESTOSTERONE & Why It's Better Than Injections'

Sep 3, 2025

Show notes:

(0:00) Intro
(1:01) The 13-year FDA journey and breaking stigmas
(4:09) Why it’s different from other oral testosterone
(6:12) Mimicking the body’s natural testosterone rhythm
(9:10) Estrogen balance, side effects, and fertility concerns
(13:51) Testosterone’s role in women’s health
(16:56) Free vs total testosterone and SHBG reduction
(24:08) Testosterone vs weight loss drugs
(29:55) Who should be cautious with testosterone therapy
(35:46) What counts as low...

Thread 'KYZATREX (oral testosterone undecanoate) Updates'

Oct 16, 2022

KYZATREX™ (testosterone undecanoate capsules)

The Power of Hormonal Balance | Restore your T- levels with Two KYZATREX capsules a day. | Discover KYZATREX Rediscover CONFIDENCE | A solution sans needles, gels, or creams

www.kyzatrex.com

KYZATREX (testosterone undecanoate) is an oral testosterone replacement therapy specifically designed for adult males with conditions associated with a deficiency or absence of endogenous testosterone, such as primary hypogonadism and hypogonadotropic hypogonadism 11 12. Here is detailed information regarding its dosage, usage, side effects, price, and efficacy:

Dosage

KYZATREX is available in capsule form in three dosage strengths: 100 mg, 150 mg, and 200 mg. The recommended starting dose is 200 mg...

Thread 'Shifting the Testosterone Treatment Paradigm with Oral Testosterone (Kyzatrex)'

Apr 18, 2025

Again you heard it here first!

Nelson's domain the one and only!

Very informative webinar on the use of the newer oral TU formulations.

Testosterone therapy has long been dominated by injectable and topical formulations, but the landscape is evolving. This webinar explores how oral testosterone is redefining treatment protocols, offering a convenient and effective alternative. With recent clinical insights and real-world data, we’ll discuss why practitioners should reconsider their approach to testosterone replacement therapy (TRT)....

post #10 (Go nuts!)

Post in thread 'Oral Testosterone Therapy in Men with Low Testosterone: A Comprehensive Review'

Nov 17, 2024

STACKED

Testosterone and Men's Hormone Health - Excel Male Health Forum

Dr. Jared Pelo interviews our advisor Andrew Y. Sun on men's hormone health and the nuances of testosterone replacement. This video goes into types of testosterone replacement and the positive benefits of utilizing this medical treatment. Do you have these questions? - What are the...

www.excelmale.com

Titratable Oral TU (Jatenzo) Achieved Similar Testosterone Levels Across BMI Subgroups - Excel Male Health Forum

* Overall, oral TU achieved similar T levels across BMI subgroups with higher BMI patients utilizing higher doses. Men may likely require different T doses based on factors such as BMI to achieve effective levels. Titratable Oral Testosterone Undecanoate Achieved Similar Testosterone Levels...

www.excelmale.com

High-Dose Oral TU Kyzatrex in Men with Low Testosterone: Safety, Efficacy, and Patient Satisfaction - Excel Male Health Forum

Hot off the press! You heard it here first, Nelson's domain is where it's at! High-dosed oral TU (Kyzatrex 400 mg) BID, LH/FSH while lower were maintained at non-zero levels, minimal impact on hematocrit! *At a mean follow up time of 6 months, patients demonstrated a significant...

www.excelmale.com

Oral TU Quickly and Effectively Achieves Serum Testosterone ≥300 NG/DL in Most Hypogonadal Men Without Dose Titrations - Excel Male Health Forum

* Overall, the starting dose of 237 mg TU BID quickly and effectively increased serum T concentrations ≥300 ng/dL in 85% of hypogonadal men. The wide distribution of serum T concentrations for the same dose (e.g., 15% <300 ng/d and 12% ≥1000 ng/dL) suggests that men likely respond differently...

www.excelmale.com

...

madman · 2025-10-12T16:19:55-0500

Post in thread 'Breaking New Ground in Men's Health: Oral Testosterone (Kyzatrex)'

Feb 7, 2025

molonlabedoc said:
How does this differ from Jetenzo?

Nothing worth fretting over!

All of the oral T formulations use testosterone undecanoate in castor oil and the PKs are similar.

Other than the older oral TU Andriol which was dosed 2-3 times daily all of the newer oral TU formulations (Jatenzo, Tlando and Kyzatrex) are dosed twice daily (am/pm) which will result in 2 daily peaks/troughs.

Starting dose and strength of capsules differ between formulations.

The older oral TU Andriol had to be taken with a high fat meal to improve absorption/bioavailability whereas the newer oral TU formulations...

madman · 2025-10-12T16:21:45-0500

Pros/Cons oral TU (51:24-57:12)

* one of the things that the orals have transformed is the concept that you have to have a continually high level of testosterone to get the benefits and clearly that's not true and the safety profile seems to be improved by having levels that fluctuate some during the day returning to close to or even baseline

Thread 'Testosterone Therapy Today: Clinical Advances & Safety with Dr. Abraham Morgentaler'

Sep 16, 2024

Dr. Morgentaler back in action!

Listen closely, loved this one!

Pros/Cons oral TU (51:24-57:12)

* one of the things that the orals have transformed is the concept that you have to have a continually high level of testosterone to get the benefits and clearly that's not true and the safety profile seems to be improved by having levels that fluctuate some during the day returning to close to or even baseline

Synopsis

Dr. Morgentaler starts by sharing his pioneering journey with testosterone...