How does Thyroid hormone effect Estrogen and Aromatase?

kashman112

New Member
I have searched for the answer endlessly and only got conflicting reports . Does Thyroid hormone ( T4,t3) reduce Estrogen or raise it ? What is their effects on the aromatase enzyme ?

Thank you . All seems very confusing and I think the TRT/testosterone community could benefit from the correct answer immensely .
 
Thyroid hormone controls thermogenesis and energy balance, especially the liver, which breaks down the estrogen and eliminates it from your body. If your liver isn’t functioning correctly, too much estrogen can accumulate.

As far as high estrogen is concerned, this may not apply to men on exogenous T, because you’re well above the natural daily release of 5-7 mg on TRT. If you’re particularly sensitive to estrogen, this can present problems.
 
Does it upregulate or downregulate the aromatase enzyme ? I have read two studies that give conflicting answers . One study says it downregulates it , the other study says that it upregulates it and caused Gynecomastia in some men when they were hyper .
 
Does it upregulate or downregulate the aromatase enzyme ?
T3 inhibited cAMP analogue 8-Br-cAMP and FSH-induced aromatase activity to a similar extent, thus suggesting that the inhibitory effect of T3 is downstream of cAMP formation.

Pretreatment of Th and Gc with T3 markedly decreased immunostaining for aromatase in both types of cells, suggesting a direct effect of T3 on this enzyme.

Thyroid hormone was shown to decrease aromatase activity in Sertoli cells by direct inhibition of the aromatase gene transcription
 


Jeez. just one more thing men with aromatase deficiency need to be aware of.
 

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