Does DHEA supplementation effect Thyroid even when on Exogenous source?

[Gianluca]

I think the answer could be possibly no, as replacing Thyroid hormone would stop the Thyroid gland producing the T4/T3 so supplementing with DHEA while of Thyroid should not effect levels correct?

 

[Sean Mosher]

That's a good question...........I believe it does aid in the conversion process of T4 to T3 and I wonder how the body would react........would it matter how the T4 got there, whether naturally or not?

 

[Vettester Chris]

It does, but more-so in a indirect manner. A DHEA imbalance will directly correlate with cortisol and the adrenals, which of course a cortisol imbalance will directly affect the transport activity of T3 into the cells of our bodies. This can result in pooling and elevated Reverse T3, which in turn becomes problematic for energy, metabolism, ATP/ mitochondria synthesis, etc ... A catabolic state if you will ...

 

[LTChris]

so are you saying that high DHEA would negatively impact thyroid conversion and increase RT3? I take exogenous DHEA (25mg daily) and have RT3 problems. DHEA levels are just above range.

 

[captain]

DHEA if low will increase TRH. TRH increases TSH and Prolactin. More TSH would make more T4 to be converted to RT3. Using TRT suppresses DHEA. This is my understanding of some of the need to supplement DHEA. DHEA and Cortisol need balance. DHEA lowers Cortisol but I don't know how much. This is what they mean when they say there is no free lunch.