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  1. FunkOdyssey

    Test ester metabolism and SC injections (everything we knew is wrong?)

    I remember a long time ago asking the question of whether depositing a testosterone oil depot in fatty tissue surrounded by aromatase could potentially increase E2 production. The universal answer: no, it couldn't possibly, because testosterone can't aromatize until the ester is cleaved off...
  2. K

    How does Thyroid hormone effect Estrogen and Aromatase?

    I have searched for the answer endlessly and only got conflicting reports . Does Thyroid hormone ( T4,t3) reduce Estrogen or raise it ? What is their effects on the aromatase enzyme ? Thank you . All seems very confusing and I think the TRT/testosterone community could benefit from the correct...
  3. D

    Lower E2 = Higher Memory Recall?

    Here is an interesting in vivo study with findings suggesting that lower levels of estrogen in the brain correlate to higher performance in varying forms of memory recall in men. @Cataceous @readalot @Nelson Vergel If a man were to experience brain fog and reduced memory recall while on TRT...
  4. M

    E2 too low, what to do?

    Been having problems with too little aromatization a while, started while i was on hcg, maybe it was jacking up progesterone and suppressing e2. Kind of ironic since usually hcg leads to higher e2. Anyway, been trying ed enanthate now, at 7.5mg, felt good for a while but once i was reaching...
  5. D


    Funny, one website says things like cruciferous vegetables, soy, herbs etc lower estrogens, the next website assures one that these same things raise estrogens. One says lowers cancer risks, Next says raises cancer risks. Surely there's a way to basically test this sort of thing?
  6. R

    Low e2 symptoms for a long time

    Hey everyone I have a huge problem with estradiol. I am constantly tormented by symptoms of low estradiol. I have not taken any IA since December. I am currently taking 100 mg test prop e2d. My mood came back for a while, but continued poping joints and being flat. I decided to hit 2500iu hcg...
  7. DixieWrecked

    Testosterone plus Nandrolone = Estrogen overload?

    If you go to 13:30 Steve talks about taking test and nandrolone together and that nandrolone is a cofactor that helps test to aromatize into Estrogen. He states that these two together is basically aromatization hyperdrive. I looked for studies on this but have nothing. Anyone know anything...
  8. C

    Brain estrogen creation 'critical to maintain full sexual activity or desire in males'

    A tip of the hat to "PakMan" at PeakT for the reference to this article. The underlying work is on mice, but may have implications for humans. Summary: Researchers have uncovered specific regions of brain tissue where aromatase is present, that drives male sexual desire. Aromatase converts...
  9. A

    Long term use of AI

    Hi, Has anyone used Aromatase Inhibitor for long time? I would like to know whats your thought on this? What are the side effects. It would be helpful if there is no serious side effects for low shbg guys. FYI: I am on low TRT dosage and I am trying to avoid AI but just wondering if anybody...
  10. D

    Myomin and Other Natural AIs

    What's up guys, Anyone have any experience using Myomin as a natural AI? I have seen some members use it here and there but not many accounts of running it all of the time. Seems to be effective from the reviews on Amazon and even seeing that some TRT doctors are recommending it first before...
  11. D

    The answer to high levels of aromatase?

    Hi all, Long time reader, first time poster. I've just come across some research which I don't believe has been discussed on here previously, and after posting in the TRT Australia group, thought certain members of this forum might find this interesting/useful. Background: 26 yrs old Lean...
  12. Nelson Vergel

    HCG, Clomid, and Anastrozole Use in Male Infertility

    New article: Click here
  13. S

    Why some men are high aromatizers - looking past the most common factors!

    Reduce your body fat, keep your diet clean and don't drink too much beer. If all those are in order you should not have problems with high estrogen. This is the reasoning we all have heard. I saw an internist a few weeks ago who said that by looking at my body type, there's no possibility for me...
  14. Nelson Vergel

    Men with high estradiol have stronger bones but more fat and less muscle

    Eur J Endocrinol. 2015 Aug;173(2):167-74. High aromatase activity in hypogonadal men is associated with higher spine bone mineral density, increased truncal fat and reduced lean mass. Aguirre LE Abstract OBJECTIVE: Because the aromatase enzyme catalyzes the conversion of testosterone to...
  15. Nelson Vergel

    Scientists report that enzyme that alters testosterone to estrogen has big impact in healthy brain

    Another reason not to mess with your aromatase activity (Most of you know my opinion about how many men on TRT are overdosing anastrozole when most do not even need it) "An enzyme that converts testosterone to estrogen appears to have significant impact in a healthy and injured brain...
  16. Nelson Vergel

    Vitamin D is anti-estrogenic where it's needed

    Vitamin D is anti-estrogenic where it's needed According to an animal and cell study that endocrinologists at Stanford University published in Endocrinology, the active form of vitamin D – calcitriol [structural formula shown below] – is an anti-oestrogen. The study is interesting...
  17. S

    Zinc and Aromatase

    In my first post I stated that my estadiol was less than 5 and my T was 502. I have been taking a zinc supplement faithfully for years, 25 to 50mg per day. Does anyone think that this is what could have pushed my estradiol so low by blocking the conversion of T to estroge ? Also as I have...
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