Gene's Nitric Oxide Stack

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)

Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)

More Than a Muscle Pump: The Surprising Science of the Nitric Oxide Stack​

In the biohacking world, we often chase complex peptides or experimental compounds, but we frequently overlook the most fundamental currency of life: blood flow. In the quest for longevity, systemic vascular efficiency is the baseline upon which all other health markers are built. As we age, our ability to maintain vasodilatory capacity diminishes, impacting everything from cognitive sharpness to metabolic health. "Gene’s Nitric Oxide Stack," a protocol born and refined within the ExcelMale community, has emerged as a definitive solution for men seeking to optimize this system. This isn't just a gym supplement routine; it is a sophisticated approach to anti-aging that leverages amino acids and targeted pharmaceutical interventions to restore the body’s most vital delivery mechanism.

Beyond the Mirror: The Science of the Sustained Pump​

For the average gym-goer, the "pump" is a transient aesthetic goal—a fleeting moment of muscle fullness. However, for a longevity specialist, a "harder pump" and increased vascularity are indicators of high-functioning endothelial health. The Nitric Oxide Stack is engineered to produce a state of vasodilation that doesn't simply vanish when you rack the weights.

By optimizing the nitric oxide signaling pathway, this protocol facilitates a sustained pump that carries through your daily life. This is a critical distinction: the visual vascularity is a proxy for your body’s ability to keep its "pipes" open. When you maintain that fullness hours after a workout, you are essentially providing proof of concept that your circulatory system is operating at peak efficiency, ensuring constant nutrient delivery to peripheral tissues.

The Foundation of Performance: Hard Science for Sexual Vitality​

One of the most immediate benefits of systemic vasodilation is the restoration of sexual function. From a clinical perspective, erection quality is often the "canary in the coal mine" for cardiovascular health. Because the Nitric Oxide Stack focuses on the root physiological requirements of performance—blood flow and retention—it provides a robust alternative to temporary fixes.

A Serious Solution for Erection Quality and Duration

This stack addresses both the quality and the duration of erections with clinical precision. For men navigating the aging process, this is not a matter of vanity, but of maintaining vital physiological function. By ensuring the vascular system can respond effectively to neurological signals, the protocol allows for a level of performance that many mistakenly believe is lost to time.

The Ultimate Nootropic: Future-Proofing the Neocortex​

Perhaps the most compelling argument for nitric oxide optimization is the "bodybuilder to brain health" pipeline. While most men start this stack for its physical benefits, they are unknowingly deploying a powerful shield against age-related cognitive decline. As we age, the micro-vasculature within the brain tends to narrow and tighten, a process that starves the brain of oxygen and is a primary driver of age-related dementia.

The stack acts as a nootropic by ensuring that the brain's smallest vessels remain dilated and resilient. This ensures that the neocortex and other critical regions receive a constant supply of the nutrients required for cognitive longevity. As the source material highlights:

"by increasing nitric oxide and getting that vascular dilation we're getting oxygen blood and nutrients in the areas of the brain that can provide us with a great anti-aging benefit in terms of neurological health."

The irony is profound: a protocol often associated with the bicep curl may actually be one of your most effective tools for protecting your mind.

Systemic Management: Blood Pressure and Prostate Function​

The benefits of the stack extend into the deeper mechanics of men’s health, specifically regarding the relaxation of smooth muscle tissue. This is particularly relevant for Benign Prostate Hyperplasia (BPH) and blood pressure management. Nitric oxide serves as a signal for these tissues to relax, directly easing the "inability to ease the problems" that typically characterize age-related prostate issues.

The secondary physiological advantages of this systemic relaxation include:

• Vascular Tension Reduction: Significant support for maintaining healthy blood pressure levels by reducing resistance within the arterial walls.
• Prostate Relief: Improvement in quality of life by relaxing the prostatic smooth muscle, easing the mechanical symptoms of BPH.
• Reduced Cardiac Load: By improving systemic flow, the heart is not required to pump against the same level of resistance, preserving cardiovascular longevity.

The Future of Your Vascular Health​

"Gene’s Nitric Oxide Stack" is far from a theoretical exercise; it is a "living protocol" backed by years of community peer-review within the ExcelMale community. The "enormously long" and widely viewed thread on ExcelMale.com serves as a testament to the real-world efficacy of this stack, offering a repository of shared experiences and optimization strategies.

This multi-front approach to anti-aging represents the best of biohacking: using fundamental biological pathways to solve complex aging problems. By focusing on the delivery system itself, we can protect our brains, our hearts, and our vitality simultaneously.

If blood flow is the delivery system for every nutrient your body needs, what happens to your longevity when you finally optimize that system?


More on Nitric Oxide in Men:

Nitric Oxide Pages

 

I believe that unless a medication is designed to be divided (IE pre scored) you can potentially get 100% of the medicine in one quarter of the pill and the other three portions could be just binder, especially off label generics made in India for domestic consumption.

http://www.drugs.com/article/pill-splitting.html

Actually that link does not substantiate your claim which IMHO is complete nonsense. If that were possible, then some 20mg pills would have 200mg and some would have zero. In order for every pill to have 20mg, the mixture must be uniform.

My experience with Cipla tadalafil is from breaking them into pieces often as small as 1/10th pill or smaller, using a scale (see my earlier post) and I have never found any variation in dosage.

Please note that India is not China. Here is the Cipla quality assurance facility:

http://www.cipla.com/Home/Facilities/Quality.aspx?mid=1291

 

Actually that link does not substantiate your claim which IMHO is complete nonsense. If that were possible, then some 20mg pills would have 200mg and some would have zero. In order for every pill to have 20mg, the mixture must be uniform.

My experience with Cipla tadalafil is from breaking them into pieces often as small as 1/10th pill or smaller, using a scale (see my earlier post) and I have never found any variation in dosage.

Please note that India is not China. Here is the Cipla quality assurance facility:

http://www.cipla.com/Home/Facilities/Quality.aspx?mid=1291

^^^^Always so impressed with your posts...seriously.

 

Thanks Gene!

Note that there is never anything personal in these discussions, just trying to get to the truth of what is going on with nitric oxide.

 

Actually that link does not substantiate your claim which IMHO is complete nonsense. If that were possible, then some 20mg pills would have 200mg and some would have zero. In order for every pill to have 20mg, the mixture must be uniform.

My experience with Cipla tadalafil is from breaking them into pieces often as small as 1/10th pill or smaller, using a scale (see my earlier post) and I have never found any variation in dosage.

Please note that India is not China. Here is the Cipla quality assurance facility:

http://www.cipla.com/Home/Facilities/Quality.aspx?mid=1291

That's perfectly logical. I tend to see the TadaCip like this having used it for several months. Seems to work some days, seems to not work some days. I was contemplating the strength of the active ingredient. For instance if a 20 is a little weak, you might not notice it but split in 1/4s, if it's weak, it could be a more observable deficiency.
I likely will not order it again and try and research chemical.

 

Actually that link does not substantiate your claim which IMHO is complete nonsense. If that were possible, then some 20mg pills would have 200mg and some would have zero. In order for every pill to have 20mg, the mixture must be uniform.

My experience with Cipla tadalafil is from breaking them into pieces often as small as 1/10th pill or smaller, using a scale (see my earlier post) and I have never found any variation in dosage.

Please note that India is not China. Here is the Cipla quality assurance facility:

http://www.cipla.com/Home/Facilities/Quality.aspx?mid=1291

Dude

Well spotted : )

Somewhere along the line I got it in my head that if a medication was not scored to be divided then it should not be divided (I think a doctor or pharmacist said it to me) and in a flawed logic chain concluded the active ingredient is not distributed uniformly throughout the medication (like for time release medications especially in capsule form) , I.E. within a single tablet, otherwise why not divide the pills? My Mistake..........

And I have to say anyone who can divide any medication into 1/10 size portions with an .88 cent pill cutter impresses me. I've been driven to near madness trying to evenly divide some big pharma products into 1/2's and 1/4's especially odd shaped pills ; ) with a $15.00 pill cutter.

I am headed to Walmart this AM I know the cutter you mentioned and wrongly concluded that for that price it couldn't possibly work.

To avoid me having to try to cut pills couldn't I just crush the pills with a pill crusher then weigh portions out?

 

God who wrong I was. After starting with a moderation of Gene´s stack my blood pressure is now normal. So next time I have an doc appointment I´ll will ask my doc to stop taking BP lowering medicin.

 

Im not Gene Devine but using the stack pre-workout minus the script Doxasin(?)....

 

Im not Gene Devine but using the stack pre-workout minus the script Doxasin(?)....

Just diet a little bit and as your weight drops watch how your veins will pop out

 

Does l-citrulline possess any "stimulant" qualities in that taking it in the evening can interfere with sleep? Much like CoQ10? Seems like my sleep is more disturbed since I began taking citrulline around mid-evening. My research I don't get the idea that it should that type of effect. Also - does taking citrulline on a regular basis causes the body to adjust to it and the need to cycle off now and then?

 

Does l-citrulline possess any "stimulant" qualities in that taking it in the evening can interfere with sleep? Much like CoQ10? Seems like my sleep is more disturbed since I began taking citrulline around mid-evening. My research I don't get the idea that it should that type of effect. Also - does taking citrulline on a regular basis causes the body to adjust to it and the need to cycle off now and then?

I don't know of any stimulation effects of any amino acid and don't know how they could even do that knowing the way they work.

IMO, the body thrives on regulatory so there is no need to "cycle" off of the amino acids to get a better effect.

I've been on this for a number of years now and still get all the great subjective benefits.

This is an excellent health stack that can be taking for years.

 

A question reg your stack.
I am not a body builder, don´t do any workouts etc.. only do some brisk walking. So the muscle building effects off your stack is not my concern but more for my general health ( inlcuding a happy mojo). Keeping that in mind, would only 1500mg day of L-arginine and +/- 6000mg free form of L-Citrulline + 2,5-5mg Tadalafil do?. I don´t know if high intake of L-arginine is really needed for someone that doesn´t do a lot of sports. I would like a different ratio between the two components and still have a good effect.

 

If you do not workout, then you do not really need L-arginine since its effect is more short term than L-citrulline, and the latter has the same result (according to sites like examine.com).

Also to croaker - I find that nitric oxide supplements (I do beets and l-citrulline together) definitely increase "energy" and that can itself have a stimulant effect. This is why I generally do those in the afternoon.

 

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)



Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


I think I put my question in the wrong area since I'm new:

I heard Nelson on Jay Campbell's hangout (which has been a great resource for me across the board).

I have tried Viagra and it did nothing for me other than what I would describe as a "head on" vs. a hard on. This was with a half a table (50 mg). Head was pounding, heart was pounding, my face got flush, and my eyes were swollen a bit. Couldn't tell you in impacted my erection much at all. I wouldn't take more given the uncomfortable symptoms.

I've recently tried Cialis - did 5 mg. Did nothing. Tried 10 mg, it did have some impact, but not rock hard. After several minutes of intercourse, it felt a bit desensitized and couldn't ejaculate as it would have taken forever. I also seemed to lose my libido after a few minutes of intercourse. I did get a flush face, but didn't have the other symptoms I had with Viagra.

I am going to try the protocol you mentioned above. I am probably 70 pounds overweight which I'm sure impacts my erections and libido. It appears as though taking the L-Carnitine and HCG will potentially help make a difference. When you say 500 IU's twice weekly, you are talking about a total of 1000 IU's?

Just to give you some context, I'm currently on .60 cc's of cypionate weekly (I was previously only .80 cc's every 5 days - I ended up gaining 8 pounds of water weight within two weeks and I my blood pressure was really high). I'm now taking .5 mg of Arimidex MWF with the .60 cc's of test weekly. I also am taking Armour thyroid 60 mg. I've also starting taking 500 mg of Metformin 2 x's a day for the last few weeks now.

Besides your suggested protocol, do you have any other recommendations for increasing my libido? Herbs don't seem to do the trick for me. Quite frankly, nothing does - nor has the test or the Arimidex (now on that for two weeks), but I know it can take time and be a process. I am exercising (not overtraining) and eating healthy (eating healthy green veggies as carbs and not eating carbs that spike my insulin) and trying to get the proper sleep, as well as avoid stress, to get my weight down (and I've lost all my water weight + 8 or 9 pounds as well), so no need to address those topics. Thank you and I look forward to learning more on your site and seeing you on Jay's site more often.

 

I had tried Viagra with poor results, as well as, single dose Cialis with poor results. Levitra provided some help without bad side effects, but still wasn't what I was hoping for.
I tried Gene's stack and after 1 week my erections were good, by the 2nd week I was having frequent erections, waking up with an erection, and having sex anytime I wanted!
It's 6 weeks in and I'm going strong. Pumps in the gym are great, too.

 

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)



Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


I think I put my question in the wrong area since I'm new:

I heard Nelson on Jay Campbell's hangout (which has been a great resource for me across the board).

I have tried Viagra and it did nothing for me other than what I would describe as a "head on" vs. a hard on. This was with a half a table (50 mg). Head was pounding, heart was pounding, my face got flush, and my eyes were swollen a bit. Couldn't tell you in impacted my erection much at all. I wouldn't take more given the uncomfortable symptoms.

I've recently tried Cialis - did 5 mg. Did nothing. Tried 10 mg, it did have some impact, but not rock hard. After several minutes of intercourse, it felt a bit desensitized and couldn't ejaculate as it would have taken forever. I also seemed to lose my libido after a few minutes of intercourse. I did get a flush face, but didn't have the other symptoms I had with Viagra.

I am going to try the protocol you mentioned above. I am probably 70 pounds overweight which I'm sure impacts my erections and libido. It appears as though taking the L-Carnitine and HCG will potentially help make a difference. When you say 500 IU's twice weekly, you are talking about a total of 1000 IU's?

Just to give you some context, I'm currently on .60 cc's of cypionate weekly (I was previously only .80 cc's every 5 days - I ended up gaining 8 pounds of water weight within two weeks and I my blood pressure was really high). I'm now taking .5 mg of Arimidex MWF with the .60 cc's of test weekly. I also am taking Armour thyroid 60 mg. I've also starting taking 500 mg of Metformin 2 x's a day for the last few weeks now.

Besides your suggested protocol, do you have any other recommendations for increasing my libido? Herbs don't seem to do the trick for me. Quite frankly, nothing does - nor has the test or the Arimidex (now on that for two weeks), but I know it can take time and be a process. I am exercising (not overtraining) and eating healthy (eating healthy green veggies as carbs and not eating carbs that spike my insulin) and trying to get the proper sleep, as well as avoid stress, to get my weight down (and I've lost all my water weight + 8 or 9 pounds as well), so no need to address those topics. Thank you and I look forward to learning more on your site and seeing you on Jay's site more often.

Maca has been shown in studies that it can increase libido.

I also take a very low dose, .25 mg twice weekly, of Cabergoline to increase libido and orgasm intensity...and it works strong in me...crazy sometimes how my libido just doesn't shut off even after a crazy love making session.

Caber is a Dopamine agonist so it increases libido and allows for a faster second orgasm in men.

 

I had tried Viagra with poor results, as well as, single dose Cialis with poor results. Levitra provided some help without bad side effects, but still wasn't what I was hoping for.
I tried Gene's stack and after 1 week my erections were good, by the 2nd week I was having frequent erections, waking up with an erection, and having sex anytime I wanted!
It's 6 weeks in and I'm going strong. Pumps in the gym are great, too.

^^^^That's what I am talking about!

Good shit man and very happy for you

 

Thank you for the responses. Question: Is this something you do every day or just when you are going to have intercourse or trying to get an intense workout? Also, if someone is on a heart medication already is Doxazosin necessary? I take 30 mg of Lisinopril. Thank you. I know you are not a doc, so I'm just speaking if it were you taking it what would you do. Thank you again.

 

^^^^That's what I am talking about!

Good shit man and very happy for you

Thanks Gene! You're a life saver.

 

Thank you for the responses. Question: Is this something you do every day or just when you are going to have intercourse or trying to get an intense workout? Also, if someone is on a heart medication already is Doxazosin necessary? I take 30 mg of Lisinopril. Thank you. I know you are not a doc, so I'm just speaking if it were you taking it what would you do. Thank you again.

I take the stack daily per Gene's guidelines, with the exception of the Dox, which I don't use at all.

 

Gene, Nelson and Dude,

Thank you guys for your time and effort getting this invaluable info out!

Gene,

Just a few comments/?s being a newbie here.
1) Does the stack ingredient amts go by bodywt?
2) Is it better to take the ingredients in powder or pill form?

Just speaking to the obvious, if it were by bodyweight, it'd be written that way, and it isn't. Fair point that a smaller person has different needs than a larger person, body composition and so forth, but Gene's recipe isn't set that way.
Second, I don't know a difference in powder or pill, high grade components though, are if high importance. You'll want to see Pharma grade, micronized, those are words sometimes associated with being more absorbable or of tested quality.