Gene's Nitric Oxide Stack

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)

Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)

More Than a Muscle Pump: The Surprising Science of the Nitric Oxide Stack​

In the biohacking world, we often chase complex peptides or experimental compounds, but we frequently overlook the most fundamental currency of life: blood flow. In the quest for longevity, systemic vascular efficiency is the baseline upon which all other health markers are built. As we age, our ability to maintain vasodilatory capacity diminishes, impacting everything from cognitive sharpness to metabolic health. "Gene’s Nitric Oxide Stack," a protocol born and refined within the ExcelMale community, has emerged as a definitive solution for men seeking to optimize this system. This isn't just a gym supplement routine; it is a sophisticated approach to anti-aging that leverages amino acids and targeted pharmaceutical interventions to restore the body’s most vital delivery mechanism.

Beyond the Mirror: The Science of the Sustained Pump​

For the average gym-goer, the "pump" is a transient aesthetic goal—a fleeting moment of muscle fullness. However, for a longevity specialist, a "harder pump" and increased vascularity are indicators of high-functioning endothelial health. The Nitric Oxide Stack is engineered to produce a state of vasodilation that doesn't simply vanish when you rack the weights.

By optimizing the nitric oxide signaling pathway, this protocol facilitates a sustained pump that carries through your daily life. This is a critical distinction: the visual vascularity is a proxy for your body’s ability to keep its "pipes" open. When you maintain that fullness hours after a workout, you are essentially providing proof of concept that your circulatory system is operating at peak efficiency, ensuring constant nutrient delivery to peripheral tissues.

The Foundation of Performance: Hard Science for Sexual Vitality​

One of the most immediate benefits of systemic vasodilation is the restoration of sexual function. From a clinical perspective, erection quality is often the "canary in the coal mine" for cardiovascular health. Because the Nitric Oxide Stack focuses on the root physiological requirements of performance—blood flow and retention—it provides a robust alternative to temporary fixes.

A Serious Solution for Erection Quality and Duration

This stack addresses both the quality and the duration of erections with clinical precision. For men navigating the aging process, this is not a matter of vanity, but of maintaining vital physiological function. By ensuring the vascular system can respond effectively to neurological signals, the protocol allows for a level of performance that many mistakenly believe is lost to time.

The Ultimate Nootropic: Future-Proofing the Neocortex​

Perhaps the most compelling argument for nitric oxide optimization is the "bodybuilder to brain health" pipeline. While most men start this stack for its physical benefits, they are unknowingly deploying a powerful shield against age-related cognitive decline. As we age, the micro-vasculature within the brain tends to narrow and tighten, a process that starves the brain of oxygen and is a primary driver of age-related dementia.

The stack acts as a nootropic by ensuring that the brain's smallest vessels remain dilated and resilient. This ensures that the neocortex and other critical regions receive a constant supply of the nutrients required for cognitive longevity. As the source material highlights:

"by increasing nitric oxide and getting that vascular dilation we're getting oxygen blood and nutrients in the areas of the brain that can provide us with a great anti-aging benefit in terms of neurological health."

The irony is profound: a protocol often associated with the bicep curl may actually be one of your most effective tools for protecting your mind.

Systemic Management: Blood Pressure and Prostate Function​

The benefits of the stack extend into the deeper mechanics of men’s health, specifically regarding the relaxation of smooth muscle tissue. This is particularly relevant for Benign Prostate Hyperplasia (BPH) and blood pressure management. Nitric oxide serves as a signal for these tissues to relax, directly easing the "inability to ease the problems" that typically characterize age-related prostate issues.

The secondary physiological advantages of this systemic relaxation include:

• Vascular Tension Reduction: Significant support for maintaining healthy blood pressure levels by reducing resistance within the arterial walls.
• Prostate Relief: Improvement in quality of life by relaxing the prostatic smooth muscle, easing the mechanical symptoms of BPH.
• Reduced Cardiac Load: By improving systemic flow, the heart is not required to pump against the same level of resistance, preserving cardiovascular longevity.

The Future of Your Vascular Health​

"Gene’s Nitric Oxide Stack" is far from a theoretical exercise; it is a "living protocol" backed by years of community peer-review within the ExcelMale community. The "enormously long" and widely viewed thread on ExcelMale.com serves as a testament to the real-world efficacy of this stack, offering a repository of shared experiences and optimization strategies.

This multi-front approach to anti-aging represents the best of biohacking: using fundamental biological pathways to solve complex aging problems. By focusing on the delivery system itself, we can protect our brains, our hearts, and our vitality simultaneously.

If blood flow is the delivery system for every nutrient your body needs, what happens to your longevity when you finally optimize that system?


More on Nitric Oxide in Men:

Nitric Oxide Pages

 

I would say that any supplement must vary by body weight - you would expect that an elephant requires a greater quantity than a mouse, of anything.

But I think that also, each person's reaction to a given dose is different. So, Gene's stack is a starting point, and feel free to adjust according to your body's reaction.

For myself, I find that any dose of tadalafil of more than 3.5mg gives me side effects, while others have no problem with 5mg.

 

Thanks Dude.
You mentioned adding red beet to the stack. Is there a particular brand that you find effective?

I use Activz, because of the handful of brands that I checked, it has the lowest price per beet - amongst those that seemed good quality. Mysteriously, the 7oz size is consistently less per ounce than the 1.1 lb size, but that may vary.

Flora is a little better tasting, but is twice as much per beet.

BeetElite Neo Shot is a decent value IF you buy the Canister (rather than the individual packets), BUT I've found I get a mild allergic reaction to Stevia (undoubtedly because it is related to ragweed), so I can't use their product.

 

Anyone had heartburn or reflux with the stack ingredients? I also get a strange tired (dull ache) feeling from sacral area down hamstrings. Took about 5 weeks to start both issues. I am going to work backwards and figure out the culprits. Taking all except the Pycogenol.

 

I do and think it is coming from the pill form of L-Arg. I am switching back to the powder. Once I take the stack and head to bed there after a while later I have heart burn. If I use powder form L-Arg I don't. That is the only difference thus I know what is causing it for me.

 

Thanks for the reply. I have been using the powder forms from Amazon in bulk. Took a long time to start those two issues though. I never had heartburn before. I was just curious if anyone else had issues.

 

I actually thought that the Doxazosin was relaxing the LES valve (Lower Esophageal sphincter) thus allowing stomach acid to elevate.

 

I get heartburn from Cialis so only take it once a day. This stack for me is way to much so I take only 50% and not all of the supplements. This stack is suppose to boost NO and should make you alert. But for me L-Citrulline can make me fatigue as well with a slight headace (it is a side effect that can happen).

 

Would this stack be appropriate for a guy who is 30, on trt, but no erection issues?

 

Would this stack be appropriate for a guy who is 30, on trt, but no erection issues?

First - ask your doctor.

Second - if you have normal blood pressure, I would say "no". If you have high blood pressure, then ask your doctor if this is an appropriate treatment for you.

 

Well I could leave out the alpha blockers etc... but having the amino acids etc might be good for me. I didnt realize this stack was only appropriate for high BP.

 

Well I could leave out the alpha blockers etc... but having the amino acids etc might be good for me. I didnt realize this stack was only appropriate for high BP.

I wouldn't quite go that far.

But for someone who is 30 years old, and has no erection issues, and has no BP issues, then your Nitric Oxide levels are probably fine.

If you workout, you can certainly use Arginine and L-Citrulline and Beets in conjunction with a workout (or distance running/cycling).

 

Would this stack be appropriate for a guy who is 30, on trt, but no erection issues?

Yes, but you would have no need for the Doxazosin and Cialis.

The rest are good supplements for blood flow and other health benefits.

If you lift and train hard and like a killer long lasting hard pump...you need to give this a try...and the vascularity is sick!!!

 

I've been doing some of this stack twice a day after first trying just Cialis first.

I first tried Cialis 5 mg 1 x a day. Nothing happened.

Tried 10 mg. 2 x's a day. Not anything special.

Tried 5 mg 2 x's a day. Better results than both of the above but still not as hard as I would like.

Tried 5 mg's only 2 x's a day with:
3000 mg of L-Arginine
1500 mg of L-Citrulline
]50 mg of Pycnogenol

Have not added any Horny Goat Weed and ]Doxazosin. ]I asked questions about Horny Goat Weed and Doxzosin but never got a response, so just went with what I have listed so far.

]And the results have been fantastic. I feel like a different guy libido and erection wise. It's like night and day. I wake up with a strong erection every morning (and if I aware during the night I have one then, too. I'm all over my wife these days as a result and I had zero luck with Testosterone, Arimidex, HCG, AND Cialis alone.

Very thankful for this information.

 

Was having daily headaches upon waking up. I've narrowed it down to the L-Arginine. When I stop taking it, headaches go away, but so does the very hard erections and strong libido. Any suggestions?

 

I am not sure of the protocol here, I don't have a response for Juan Valdez, just a comment regarding TRT and Gene's stack. I'll keep it simple - TRT has helped me immensely with energy, mood and endurance but did not do much for libido or getting erections. I don't want to minimize the effects of TRT - I am a different person and am enjoying life so much more than I had thought possible. However, I did miss the libido of my youth and when I read through the threads of Gene's stack I thought I would give it a whirl. So far all I have done is the L-arginine and citrulline and the effect was immediate - rock hard erections and a stronger libido. A major thank you to Vergel, to Gene, and to everyone who contributes to this site. At 57 years old I feel as good as I have every felt at any age.

 

I am not sure of the protocol here, I don't have a response for Juan Valdez, just a comment regarding TRT and Gene's stack. I'll keep it simple - TRT has helped me immensely with energy, mood and endurance but did not do much for libido or getting erections. I don't want to minimize the effects of TRT - I am a different person and am enjoying life so much more than I had thought possible. However, I did miss the libido of my youth and when I read through the threads of Gene's stack I thought I would give it a whirl. So far all I have done is the L-arginine and citrulline and the effect was immediate - rock hard erections and a stronger libido. A major thank you to Vergel, to Gene, and to everyone who contributes to this site. At 57 years old I feel as good as I have every felt at any age.

^^^^Good stuff!

 

Gene - Do you have any advice if L-Arginine give headaches?

 

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)



Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)



Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)

Gene, I just found your "stack" and I am totally in shock. I have been working for years on my "stack" (without ever seeing yours) and I came virtually to the same stack composition. There are only minor differences which are as follows:

10-20 mg Tadalafil (Cialis) / day
2800 mg l-Arginine 2x / day
1200 mg l-Citruline 2x / day
3000 mg d-Aspartic acid / day
200 mg Pycnogenol / day
600 to 1200 mg of pure 60% Icariin / day
1200 to 2400 mg Horny Goat Weed / day
160-320 mg Tongkat Ali / day
1 mg of Doxazosin 1 - 3 times a day

In addition I take 10 mg AndroGel / day

My stack composition is same as yours except I have 2 additional components. Also I am bit more flexible with the daily amounts and timing: I can VERY CLEARLY FEEL how is the stack working so I slightly adjust daily total amounts to my morning feeling from the previous day stack impact on my body and also on my plans for the day. What shocks me most is how similar our stacks are. Also, I am not that heavily into body building, I am more into longevity (I am 77 YO) and sex performance optimization. Regarding the erection and sex performance, this stack is an absolute killer.

 

I guess not.

 

Look for quality and purity indicators on your L-Arginine, modify the dosage and timing, or just stop taking it.