E2 Crash Recovery

marcos79

New Member
I seem to have crashed my E2 earlier this month after anastrozole overuse. My E2 was <5.0 on 11/8, but has since bounced back to 30.7 on 11/16. However, I'm still not feeling much relief, specifically from the ed and low libido. I have been taking clomid and HCG since the crashed however (for cycle PCT). I understand that those meds can prevent your receptors from "feeling" the E2 come back. So on the advice of a trusted member, I have discontinued the PCT meds.

My question is: for those of you who have crashed your E2 in the past (specifically on anastrozole), about how long it did take to recover your sexual function? Did anyone not recover?
 
I haven’t recovered from Aromasin crashing my estrogen. It’s been since 2020. I recently got my bloods done and saw that my test was 413ng and estradiol was at 18 where before it used to sit at 791ng and 37. Since that bloodwork I’ve tried two pcts. The first was with Enclomiphene and I actually felt better a couple weeks after this one but then my symptoms set in again. Then I tried clomid and this didn’t help my symptoms. At this point I may just hop on trt to try and raise my estrogen levels to see if it will help. Not sure if my symptoms are hypogonadism from using testosterone or a receptor issue. I will update once I try trt.
 

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HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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