Questions for men on anastrozole who have crashed their E2 Levels

There’s a small portion of us that have really bad reactions to aromatase-inhibitors. I took one 5 months ago and after a wild panic attack 2 days later, I literally could not sleep for almost 2 months, after sleeping like a rock for 31 years of my life. Had some other wild symptoms, crazy heart palps, muscle twitches etc. Never experienced anything like this in my life. I’ve made considerable progress but still not my old self, getting maybe 4 hours of sleep a night and my head has this weird effervescent feeling.
 
I have a few questions for those who have crashed their e2 levels.

How low did your E2 levels go?
How long did it take to recover?
Did anything help you raise your levels?

I have searched on this and other forums and all I can see is that people have either upped their test dose, which for me any test only makes everything so much worse (think of an anxiety attack that lasts for the entire day, only Xanax or a boat load of alcoholic beverages seem to calm down for like 8 days) , Taken a huge amount of HCG (not sure if this works), and or added more DHEA-Pregnenolone, which I have started to do but is not having that much of an impact.

Back Story
Back on May23rd I crashed my e2, was @ 9 on the sensitive test <=29 , then took 2.mg of anastrozole on the 26th, thought the symptoms I was having were signs of elevated E2 levels (got the results back from my blood test a few days later). Have been through hell the past couple months, Anxiety that cripples and lasts all day, Fatigue, Insomnia, Dry Skin. July 11th had another blood test run and my E2 levels were @ 11and still having milder Anxiety, Fatigue, Insomnia, Dry Skin.
What’s your injection frequency? Are you fine now?
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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