trt

  1. L

    No Results on TRT—Adrenal Crisis? Low Cortisol & need HELP!

    My body has been wrecked since 2020. (got COVID19 June 2020, then hit by 2 hurricanes, August & October 2020). I am not sure if COVID was solely responsible for my current issues or the mix of two high stress environments caused me burn out to the point of adrenal failure which is what I believe...
  2. M

    Advice on PCT Protocol After 3 Years on TRT?

    Hi everyone, I’m looking for advice on the best way to structure my PCT after being on TRT for about 3 years, specifically whether enclomiphene should overlap with HCG or only after HCG is discontinued. Here’s my full background and current plan: TRT History On TRT for ~3 years total Started...
  3. T

    Ancedotes of feeling better when taking time off injections.. Science behind this?

    Ive experienced and have seen others who have had trouble dialing in, that take days or a week of their protocol and feel so much better.. Ive felt this myself and cant figure it out. Its not as simple as the dose being to high, because I took some days off then adjusted my dose down 25% and the...
  4. was3dev

    Axis Protocol TRT tracking app beta looking for feedback

    Hey guys, I've been on TRT for about a year and wanted a way to visualize what's happening between doses and correlate it with how I feel day to day. I'm a dev, so I built what I wanted. Axis estimates testosterone levels between shots using a pharmacokinetic model. You can log symptoms and...
  5. P

    Differences in hematocrit impact between different application protocols

    https://pubmed.ncbi.nlm.nih.gov/34445892/ Abstract Purpose: We sought to compare testosterone formulations and determine the degree that hematocrit increases vary by testosterone therapy formulation. As head-to-head trials are rare, network meta-analysis of the contemporary studies is the only...
  6. T

    E2 keeps climbing slowly over several months on EOD injections

    Above is above is Most recent test at 28-30mg EOD. Below is test from end of July at 24-26mg EOD. Yes I feel like shit, and my shbg was 9.8! Im doing subq EOD and just recently am trying ED injections. I dont understand how my e2 has trippled? Does anyone have any input on this? What route...
  7. T

    TRT and potential side effects?

    I know I just started TRT at 140mg a dose with hcg. I'm never looking to go crazy then I need to and take more anabolic steroids. With under supervision, a lot of the risk can be mitigated? Even lets say I want to run TRT at least to change composition of how fat I look now to a bit fitted. From...
  8. S

    TRT clinics...hard to trust sometimes (my numbers)

    I've been on TRT for years, through the same clinic. I hadn't been taking my AI during that time, but the doc really, really felt that my numbers should be lower than 20, so he advised me to give it a try. Just did the blood work and yikes. T: 950 E: < 5 SHBG: 30 All of my other numbers are...
  9. R

    TRT Review - Low SHBG, High E2, Crashing Libido

    Hey guys, Looking for some advice on my TRT protocol. I'm 21, had testicular cancer last year (orchiectomy + chemo, now in remission). Been on TRT for about 3 months, trying to dial it in since I'm still having issues. Here's the situation: Complaint: Zero libido, some anhedonia, water...
  10. madman

    Mohit Khera, MD, recaps key takeaways from FDA panel on TRT for men

    https://www.urologytimes.com/view/mohit-khera-md-recaps-key-takeaways-from-fda-panel-on-trt-for-men Mohit Khera, MD, MBA, MPH, recaps key takeaways from an FDA expert panel discussion on testosterone replacement therapy for men. In a recent interview with Urology Times®, Mohit Khera, MD, MBA...
  11. madman

    Marius Pharmaceuticals CEO Shalin Shah Invited to Speak at Landmark FDA Expert Panel on Testosterone Replacement Therapy for Men

    * This landmark event marks a pivotal moment in the advancement of men’s health and represents a major milestone for Marius, which has worked for years to elevate the scientific conversation surrounding testosterone and address longstanding misconceptions. * Shah will join an esteemed group of...
  12. madman

    Can Testosterone Therapy HELP Prostate Cancer?

    In this episode, Dr. Brandon & Dr. Morgentaler talk about the emerging evidence that testosterone therapy may be safe—and even beneficial—for men with metastatic prostate cancer. Chapters 00:11 – Testosterone Use in Metastatic Prostate Cancer Dr. Morgentaler introduces the surprising...
  13. B

    HCG + Clomid or HCG only ?

    I am 46 years old and I`ve been on TRT for around 7 years. I decided to try and stop TRT because It has been mostly ok but I struggle with libido and sensitivity down there as well as difficulty ejaculating and reaching orgasm although my testosterone was quite OK between always between 700 -...
  14. H

    Test cyp 6 months - still can't dial in

    Hi guys, Bit of context, I’m a 28-year-old male. I started TRT because of brain fog and wanting better muscle gains. When I first started Test Cypionate at 100 mg per week divided into 3 injections, I felt great for the first few weeks. But then I developed insomnia, bloating, and ED. I...
  15. madman

    Upcoming FDA Expert Panel on Testosterone Replacement Therapy for Men

    @Nelson Vergel We need you here! https://www.fda.gov/patients/fda-expert-panels/fda-expert-panel-testosterone-replacement-therapy-men-12102025 Location: FDA White Oak Campus, 10903 New Hampshire Ave., Building 31, Great Room, Silver Spring, MD 20993-0002. There will be limited seating...
  16. madman

    Subcutaneous Testosterone Injections: A Safer, Smoother Low T Solution for Men With Hypogonadism

    * SubQ injectable TRT is a relatively novel therapy aimed at minimizing the drawbacks associated with IM TRT while potentially offering steadier absorption. * This IRB-approved study (22111501) investigated our institution’s use of non-proprietary SubQ TRT with testosterone cypionate (T CYP)...
  17. madman

    Why Testosterone Decline Is the New Health Epidemic

    Shalin Shah is the CEO of Marius Pharmaceuticals and a leader in metabolic and men’s health. He spearheaded the FDA approval of the first oral testosterone therapy for men with low testosterone. With a mission to make hormone health more accessible, Shalin advocates for education, innovation...
  18. S

    TRT Ups and Downs

    Hey guys….new here and just looking for some guidance. I’m a 51 year old male who I consider in pretty good shape. 5’9” and 180 lbs. I do CrossFit 3-4 days a week. I take no prescription medications. Only a couple of supplements. Very healthy with no risk factors for ED. Beginning of this year...
  19. madman

    TESTOSTERONE: A SAFETY UPDATE 2025

    Professor Michael Zitzmann We also know hematocrit can be increased by testosterone preparations. It depends on the preparation, and we think that there is data that shows that the threshold of 52-54% should not be surpassed, and men should be controlled for the hematocrit especially in the...
  20. madman

    Testosterone Controversies: Lessons Learned from TRAVERSE 2025

    * Miner emphasized that TRAVERSE has reshaped the safety narrative around testosterone replacement therapy (TRT), easing concerns about cardiovascular and prostate risks. Many men with hypogonadism—who often suffer from fatigue, mood changes, and depression—are now more open to discussing TRT as...
  21. L

    How long does testosterone drop after stopping

    I have been taking 200mg of cypionate twice weekly for 12 weeks. I am "supposed" to be take 200mg bi-weekly. My doctor wants a blood test. How long after stopping the injections will my levels drop. Should I do PCT or just slowly go back to bi-weekly?
  22. M

    1mg microdosing aromasin for mild E2 increase with symptoms

    Hey all, I'm new here so I hope this question is ok as I've not found much on this low level of dosage. I've been dealing with high e2 symptoms for a while and my E2 is creeping up (currently 48pg/ml). Not super high but very high for me as I started trt at 15pg/ml. I just aromatize kinda...
  23. madman

    Testosterone Breakthrough: A New Testosterone Solution Rocking the HRT World

    48:03: How to prescribe and access Kyzatrex How to Prescribe Through selected compounding and mail-order pharmacies, not at chain stores (CVS/Walgreens), keeping costs low and access high. Prescriptions are cash pay but often below compounding pharmacy prices—no insurance required. Another...
  24. madman

    Testosterone Replacement in Cardiac Patients and Sexual Health

    Prof. Dr. Omer Raheem Post-Myocardial Infraction TRT Conclusion
  25. madman

    Raise Testosterone, Preserve Fertility: Enclomiphene vs Clomiphene vs TRT

    Enclomiphene can boost testosterone while preserving fertility. Board-certified urologist Dr. Justin Houman explains enclomiphene vs clomiphene and TRT, dosing, results (150–200 point T rise), side effects, labs, and who should use it. If you’re a younger guy with low T who still wants kids...
  26. T

    DHT Cream dosing help

    Hello, I got 10% DHT cream in lipsomal base 50ml. How much of cream do I use per day? There is no instructions or dosing. Im using it for the purpose of PFS. Im on TRT cream as well. Thanks
  27. madman

    Can You Take Testosterone and Still Have Kids? What Every Man Needs to Know

    TRT can change your hormones — but it may also shut down your sperm. In this video, Dr. Justin Houman (MD, board-certified urologist & men’s health specialist) explains how testosterone replacement therapy affects fertility, sperm count, and testicular function, how long recovery can take, and...
  28. madman

    Free vs Total Testosterone: What Most Men (and Doctors) Get Wrong

    Free testosterone vs total testosterone — which one actually matters? In this video, Dr. Justin Houman, board-certified urologist and men’s health specialist, explains the key difference between total testosterone and free testosterone, how sex hormone binding globulin (SHBG) affects your...
  29. madman

    Undecatrex™ an FDA-approved authorized generic version of Kyzatrex® is now available

    An Authorized Generic version of Kyzatrex has been approved. * An Authorized Generic is a prescription drug that is produced by a brand company under a New Drug Application (NDA) and marketed as a generic under a private label. It is identical to the branded product in appearance and has...
  30. madman

    KYZATREX® Safe for your liver: Lymphatic Absorption

    * The good news is that KYZATREX was specifically designed to be absorbed lymphatically. This means it bypasses your liver avoiding the liver toxicity associated with oral testosterone medications of the past. Kyzatrex® (testosterone undecanoate) an oral testosterone therapy Taken...
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