The $49 Test That Saves Lives: Dr. Mohit Khera’s Warning for Men Over 40

[madman]

You would mean the $49 test which includes the most critical blood marker free testosterone tested using the most accurate assay the gold standard Equilibrium Dialysis!

Testosterone, Free (Equilibrium Dialysis) and Total, MS | Discounted Labs

Get an affordable and accurate testosterone test results with our Total Testosterone, M and Free (Equilibrium Dialysis) test. Visit DiscountedLabs.com for more information.

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I agree Dr. Khera is a true powerhouse in the field!


Dr. Morgentaler

* Dr. Mohit Khera, arguably the most important figure today in sexual medicine in the world!




Listen closely!

19:16 Testing and Overprescribing — The tension between needed awareness and the risks of misuse or over-treatment.

In this episode, Dr. Morgentaler and Dr. Brandon have a special guest, Dr. Mohit Khera, and they discuss how testosterone, lifestyle, and modern stressors impact overall health, fertility, and intimacy, while highlighting the importance of proactive care to preserve long-term sexual and relational well-being.




Chapters

00:00 Meet Dr Khera — Introduction to a leading expert in sexual medicine and his impact on the field.


03:20 Testosterone and Prostate Cancer Shift — How research flipped the narrative from fear to potential therapeutic use.


06:56 Low T Health and Treatment Debate — Why testosterone is a key health marker yet still misunderstood and debated in medicine.


19:16 Testing and Overprescribing — The tension between needed awareness and the risks of misuse or over-treatment.


23:57 Fertility Safe Alternatives — How younger men can boost testosterone safely without harming fertility.


29:07 Stress Porn and Sexspan — How stress, sleep, and modern habits like porn are reshaping sexual health and long-term desire.

Thread 'The complications of multi-drug TRT (hCG; AIs; SERMs; 5ARIs)'

Dec 20, 2025

All those dime a dozen run of the mill T-clinics!

High dosed T off the hop with an AI thrown in to boot LMFAO!


* He explains that medications such as anastrozole, hCG, clomiphene, and enclomiphene—tools used thoughtfully in academic urology for specific indications—are now often bundled automatically with TRT, even when they are unnecessary or inappropriate. This trend, he argues, stems from widespread misinterpretation of medical literature and a lack of individualized clinical judgment.




TRT + clomiphene.....NAH!

3:11-3:55

* In contrast...

• madman
• hypogonadism; t-therapy; hcg; clomid; anastrozole
• Replies: 7
• Forum: Testosterone and Men's Health Articles

 

[madman]

Thread 'Hypogonadism 101'

May 12, 2023

Hypogonadism 101

• madman
• hypogonadism; testosterone therapy;; men's health
• Replies: 42
• Forum: Testosterone Basics & Questions

Thread 'New Perspectives in the Diagnosis and Management of Hypogonadism'

Oct 20, 2023

Only at Nelson's domain.

Enjoyed this one.

Dr. Khera and Dr. Mulhalll, are two giants in the field here!

• madman
• hypogonadism; testosterone; trt; men's health
• Replies: 14
• Forum: Testosterone and Men's Health Articles

• 

Thread 'Testosterone & Hypogonadism: A Clinical Perspective'

Oct 4, 2023

First, Dr. Khera explains how comorbid conditions, such as diabetes, metabolic syndrome, and obesity, can decrease testosterone levels as men age. We also discuss the importance of the four pillars of health - diet, exercise, sleep, and stress reduction - and the role of weight loss in increasing natural testosterone levels. Additionally, Dr. Kera outlines the lab results he orders to confirm hypogonadism, which includes testosterone, free testosterone, LH, FSH, prolactin, estradiol, DHT, TSH, IGF-1, and vitamins D and B12.

Next, Dr. Khera...

• madman
• hypogonadism; trt; testosterone; men's health
• Replies: 9
• Forum: Testosterone and Men's Health Articles

Thread 'Testosterone Replacement After Prostate Cancer: Safety, Benefits & Latest Research Uncovered'

Aug 9, 2025

* Gaps in long-term data and areas for further research are identified, underscoring the need for careful application in clinical practice. This paper emphasises a multidisciplinary approach in patient selection, rigorous monitoring protocols, and fully informed decision-making. By presenting a comprehensive review of the evidence, we aim to clarify the role of TRT in improving quality of life for men in remission from prostate cancer, while ensuring that oncological safety remains the highest priority.




Table 1 Comparison of TRT Guidelines from BSSM, AUA, and EAU...

• madman
• pca/active surveillance; testosterone therapy
• Replies: 6
• Forum: Prostate Related Issues

Thread 'TRT and the Prostate'

Mar 4, 2022

Testosterone Treatment and the Risk of Prostate Adverse Events (2022)
Jason A. Levy, DO, MS, Arthur L. Burnett, MD, MBA, Adrian S. Dobs, MD, MHS



INTRODUCTION

Definition Hypogonadism is a clinical syndrome that results from failure of the testis to produce physiologic concentrations of testosterone (T).1 Various thresholds exist to define low total T ranging from 230 to 350 ng/dL. Peak T levels typically are measured between 3 and 8 AM with total T level decreasing during the first 30 minutes of waking.2Serum T decreases with age and has shown to have an...

• madman
• testosterone; bph/luts; pca
• Replies: 25
• Forum: Prostate Related Issues

• 

Thread 'Testosterone and Cardiovascular Risk: The TRAVERSE Trial and Results from the New FDA Label Change'

Apr 25, 2025

Mohit Khera, MD, MBA, MPH, Professor of Urology and F. Brantley Scott Chair of Urology, Baylor College of Medicine, Houston, Texas, discusses evolving understanding of testosterone therapy and cardiovascular risk. In this 13-minute presentation, Dr. Khera focuses on the pivotal TRAVERSE trial and the recent announcement regarding class-wide labeling changes for testosterone products.




History of CV Events and Testosterone Therapy

Dr. Khera traces the history of concern of cardiovascular risks with testosterone...

• madman
• hypogonadism; t therapy; cvd; fda
• Replies: 10
• Forum: Testosterone and Men's Health Articles

Thread 'TRT and Cardiovascular Disease'

Feb 18, 2022

Testosterone replacement therapy and cardiovascular disease (2022)
Jeremy M. Auerbach and Mohit Khera


The use of testosterone therapy has a complex history of apprehension and questions regarding its safety. Despite an eventual consensus that testosterone therapy was safe and effective, several studies relating to cardiovascular risks emerged in the last decade, rekindling skepticism regarding the safety of testosterone therapy. Given the utility of testosterone therapy in treating the symptoms of hypogonadism, it remains crucial to closely examine the safety of testosterone...

• madman
• testosterone; cvd
• Replies: 24
• Forum: Testosterone and Men's Health Articles

• 

Thread 'Testosterone Controversies: Lessons Learned from TRAVERSE 2025'

Nov 7, 2025

* Miner emphasized that TRAVERSE has reshaped the safety narrative around testosterone replacement therapy (TRT), easing concerns about cardiovascular and prostate risks. Many men with hypogonadism—who often suffer from fatigue, mood changes, and depression—are now more open to discussing TRT as a legitimate treatment rather than a “lifestyle drug.” Still, he noted limitations: TRAVERSE used testosterone gel formulations, leaving unanswered questions about the safety of higher serum levels achieved with injectable testosterone. Future research comparing different...

• madman
• hypogonadism; trt; traverse; cvd; mens health
• Replies: 3
• Forum: Testosterone and Men's Health Articles

 

[madman]

Again!

So much misinformation littered on the net its sickening.

As I have stated numerous times on the forum T is a threshold hormone!

Main point here being start low and go slow titrate the dose if need be until the threshold is crossed (bloodwork + symptoms).

Symptoms improved while at the same time minimizing/avoiding sides, keeping blood markers healthy and maintaining long-term health is key here.

Crossing the threshold turns the lights on but cranking the dimmer switch past that doesn't make them shine brighter. It's a ceiling effect, not a linear dose-response.

Especially when it comes to libido and erectile function.

The majority of symptoms will be improved once you achieve a healthy FT which for most would be aiming for a healthy/high-end trough 15-25 ng/dL.

Yes some will choose to run higher levels but the main benefit you are going to get here when driving up your FT sky-high is better gains in muscle/enhanced strength and recovery.

Plain and simple.

Every other symptom energy, mood, libido, erectile function let alone overall health (cardiovascular, brain, bone, tendons, immune system, lipids, and body composition) can easily be improved by achieving a healthy FT.

Even then I would put much more weight behind sleep, diet, exercise, thyroid/adrenals and stress (physical/mental) when it comes to energy, mood, libido, erectile function and overall health than supposedly needing a high/absurdly high FT.

This is a given!

Give your heads a shake peak--->trough (daily vs twice-weekly vs once weekly).

24/7 steady-state to boot!

Healthy natty males age 18-29 years mFT 2.5-97.5th percentile 6.39-25.3 ng/dL.

It's those natty outliers that fall in the 97.5% that are hitting a FT 25.3 ng/dL and this is a daily short-lived peak to boot!

Better yet look at where the median 11.71 ng/dL sits!

Thread 'Largest dataset of mFT levels to date: male reference ranges spanning a wide age range, using a gold standard Equilibrium Dialysis LC-MS/MS method'

Mar 14, 2026

Sit and dwell on that!

Think of all those overmedicated men on T-therapy gassed up on FT well beyond their natty genetic set-point and unfortunately many off them off the hop!

You can blame all those run of the mill T clinics, kiddie forums loaded with all those numbskulls, throw those blast n cruisers in there too and put the icing on the cake the cesspool of so called gurus polluting gootube!

Gotta love all those kiddie forums loaded with the brainwashed sheep still pushing that more T is better mentality dishing out piss poor advice!

So much misinformation littered on the net its...

• madman
• hypogonadism; ft; refernce ranges; assays
• Replies: 8
• Forum: Testosterone and Men's Health Articles

• 

 

[madman]

No one should be using/relying on the known to be inaccurate direct IA (CLIA/RIA)!

As I have been preaching on the forum for years everyone needs to have the most critical blood marker free testosterone tested using the most accurate assay the gold standard Equilibrium Dialysis especially in cases of altered SHBG (high/low) to know where it truly sits!

Otherwise you will need to use/rely on the next best testing method the go to calculated linear law-of-mass action Vermeulen (cFTV) which will give a good approximation.

Free & Bioavailable Testosterone calculator

These are the assays you need to use when testing TT and more importantly FT!

Most accurate assays TT (LC-MS/MS) and FT (EquilibriumDialysis)

$49

Testosterone, Free (Equilibrium Dialysis) and Total, MS | Discounted Labs

Get an affordable and accurate testosterone test results with our Total Testosterone, M and Free (Equilibrium Dialysis) test. Visit DiscountedLabs.com for more information.

www.discountedlabs.com

Again!

FT <5 ng/dL would be considerd low.

FT 5-9 ng/dL would be considered the grey zone where some men may experience symptoms of low-T.

FT 10-15 ng/dL would be healthy.

FT 20-25 ng/dL would be high-end/high.

The majority of men will do well with a trough FT 15-25 ng/dL depending on the injection frequency.