trt

  1. M

    TRT doubts 8 weeks in

    Hi guys, I am 8 weeks into trt, enanthat 40mg e3.5d subQ. Started low, as I was having a history 6 years ago with trt and elevated hematocrit. My results came in and I was shocked. HCT already came back at 52.2 and total T at 11.8ng/ml which was surprisingly high as well for that low dose...
  2. madman

    What You Don't Know About Testosterone

    Shalin Shah explains how testosterone serves as a key biomarker for overall health and outlines common symptoms that indicate testing is needed: including fatigue, muscle loss, and decreased libido. He emphasizes that while lifestyle factors like diet, sleep, and exercise are foundational...
  3. S

    MCT TRT issue anyone? Possible side effects?

    Hi team. Been on a TRT journey for a year. One of the biggest takeaways I've learned here is to stay the coarse, try not to change dosage and timing often, things will stabilize. But, in doing so I am feeling off, constantly...its been going on for 6 months. After months of trial and...
  4. madman

    CDC HoST-TT Certification for Siemens Healthineers Total Testosterone Test Expands Patient Access to Gold Standard Equivalent Results

    * The CDC’s Clinical Hormone Standardization Programs standardize the total testosterone assay so that results are accurate, comparable, and clinically meaningful wherever they are performed * By calibrating assays to a common reference method and enforcing stringent performance criteria, CDC...
  5. madman

    Why Pfizer Stopped Selling DEPO®-TESTOSTERONE in Canada

    Was bound to happen sooner or later! There was still some limited back stock floating around. I am sitting on numerous vials and have some Delatestryl left to boot. All we have know are slim pickings the two generics Hikma TE and Taro TC. Even then everyone is going to be stuck with the Taro...
  6. T

    TRT dosing help

    0.30 ml enanthate E3D put me at 742 trough free T PMOL, Total T 30nmol and shbg 8 (single digit shbg always) I felt really good on this dose but then i lowered to 0.20 E3D, and i started getting a bit of brain fog, less drive and motivation. My urologicst doesen’t keep people over the reference...
  7. madman

    Nebido Is Coming to Canada: What It Means for Testosterone Supply and Shortages

    Nothing ground breaking here as the majority of men will stick with the go to medium acting esterified TC/TE! Flexible dosing and easily titrated are key here let alone weekly injections whether once weekly or more frequently take the cake when it comes to taking advantage of the anabolic...
  8. madman

    Advanced Equilibrium Dialysis for Free Testosterone: A New Standard in HRT Testing

    48-Position Custom Deep Well Plate For In Vitro Equilibrium Dialysis at a 1:1 Sample to Buffer Volume Ratio * CDC scientists have developed a new design for a multi-well dialysis microplate for equilibrium dialysis. The unique design accommodates a 1:1 buffer to sample ratio and provides...
  9. G

    Thinking about starting TRT. Advice?

    I’m on the fence about starting TRT. A little backround about me. 31(M) at roughly 16% BF with a healthy overall lifestyle. I workout 4x per week, eat healthy for the most part, and sleep 8 hours per night. Supplements I’m currently taking are a multivitamin, vitamin D, magnesium, zinc, and...
  10. madman

    TRT and Sleep Apnea Risk: Why Testosterone Therapy May Increase OSA Risk—Especially in Men Under 50

    Abstract INTRODUCTION AND OBJECTIVES: The relationship between testosterone replacement therapy (TRT) and obstructive sleep apnea (OSA) is an emerging field of interest. TRT is typically contraindicated in patients with severe uncontrolled OSA, but our previous research has shown OSA risk...
  11. madman

    hCG on TRT: How Adjunct Therapy May Improve Strength, Endurance, and Energy in Active Men

    Abstract INTRODUCTION AND OBJECTIVES: Human chorionic gonadotropin (HCG) is commonly added to testosterone therapy (TTh) to preserve testicular function. In clinical experience, many men with testosterone deficiency express a preference for adjunctive HCG with TTh. We performed a...
  12. madman

    TRT-Induced Azoospermia: Why hCG and Gonadotropin Levels Don’t Predict Sperm Recovery

    Abstract INTRODUCTION AND OBJECTIVES: The use of testosterone replacement therapy (TRT) among men is rising leading to an increasing number of men with TRT induced azoospermia from hypothalamic-pituitary-gonadal (HPG) axis suppression. Human chorionic gonadotropin (HCG) is used to mitigate...
  13. madman

    Clomid for Low Testosterone: Why It May Lower HDL and Affect Cholesterol Despite Boosting Hormones

    Abstract INTRODUCTION AND OBJECTIVES: Clomiphene citrate (CC) is increasingly used off-label to treat male hypogonadism while preserving gonadal function. CC has been associated with dyslipidemia in women treated for ovulatory dysfunction, and preliminary data from our institution previously...
  14. madman

    Normal Testosterone Isn’t Enough: How SHBG Hides Low Free T in Older Men

    Abstract INTRODUCTION AND OBJECTIVES: Total testosterone (TT) measurement is widely used to diagnose male hypogonadism (MH). However, TT may be normal despite androgen deficiency when sex hormone-binding globulin (SHBG) is elevated, a condition often associated with ageing and chronic...
  15. madman

    Azoospermia on TRT? hCG vs Clomid for Fertility—Why Sperm Recovery May Not Depend on FSH

    Abstract INTRODUCTION AND OBJECTIVES: To evaluate FSH recovery rates and sperm production in men with testosterone therapy (TTh)-induced azoospermia treated with hCG alone versus hCG combined with clomiphene citrate, focusing on men with severely suppressed baseline FSH. METHODS...
  16. madman

    Why Normal Testosterone Levels May Still Cause Symptoms: The Hidden Role of CAG Repeat Length in TRT

    Abstract INTRODUCTION AND OBJECTIVES: The preferred treatment for hypogonadism, testosterone replacement therapy (TRT), has a varying efficacy that is currently not understood. This observation may be explained by polymorphism of the androgen receptor (AR), a ligand-binding transcription factor...
  17. madman

    Once-Weekly hCG Helps Preserve Fertility in Men on Testosterone Therapy (Largest Study Yet)

    Abstract INTRODUCTION AND OBJECTIVES: Testosterone therapy (TTh) is known to suppress spermatogenesis, but combination TTh with human chorionic gonadotropin (hCG) has been shown to maintain spermatogenesis in a small 26-patient case series. That study did not account for prior fertility (or...
  18. madman

    Dr Jeff Foster - Director of Men’s Health at Voy/Manual (UK)

    https://www.joinvoy.com/experts/dr-jeff-foster https://www.h3health.co.uk/ https://www.joinvoy.com/trt https://www.excelmale.com/threads/british-society-for-sexual-medicine-guidelines-on-male-adult-td.27188/...
  19. M

    Crashed E2 from eq

    Hello guys so recently I got my estrogen sensitive test back and it was 5 Side effect been sleep is trash no amount supplements such as melatonin or magnesium helping at all brain fog feeling tired over all And tbh I had gotten my estrogen back up and I noticed those side effects never went...
  20. madman

    Comparative review of the PK and PD of testosterone therapies in T2DM

  21. P

    Considering setting up an AI Agent for trt research and looking for input

    Been thinking about this for a while and might actually go through with the project. As someone in the tech field who has been interested in health and research for decades I’ve started to consider the combing the two now that tech has reached it’s current state(and only getting better). These...
  22. B

    Seeking Advice. Off Test Six Months. Test Still Low.

    Just done my 6 month blood test and my test remains unchanged since December 2025. Very low!!!! These are my results: Oestradiol <19 (pmol/L) Testosterone (total) 4.6 (nmol/L) Free Testosterone 0.09 (nmol/L) FSH 2.6 (IU/L) LH 1.3 (IU/L) SHBG 28.6 (nmol/L) For context, my pre-TRT baseline...
  23. madman

    Controversies with Testosterone Replacement Therapy

    Dr. Khera of course! * if you prescribe testosterone there are five controversies you have to know about! Mohit Khera, MD, MBA, MPH Professor of Urology F. Brantley Scott Chair in Urology Director, Laboratory for Andrology Research Faculty Group Practice Medical Director Baylor College...
  24. madman

    Experts react to FDA’s potential pathway for TRT label expansion

    Following the FDA’s announcement on a potential pathway to expand testosterone replacement therapy (TRT) labeling,1 leading experts in men’s health shared their perspectives on what this development could mean for patients and clinical practice.
  25. madman

    FDA Signals Potential Expansion of Testosterone Therapy to Treat Low Libido in Idiopathic Hypogonadism

    https://www.ajmc.com/view/fda-signals-potential-expansion-of-testosterone-therapy-to-treat-low-libido-in-idiopathic-hypogonadism https://www.fda.gov/news-events/press-announcements/fda-takes-step-forward-testosterone-therapy-men The U.S. Food and Drug Administration today is taking an...
  26. N

    Just found out I’m MTHFR

    Been on trt for 15 years. Results have been subpar, havnt really felt that great even with good testosterone levels and if I tried to get the number higher into the high end of normal I would feel real shitty within days. I now believe this was because of the double MTHFR gene mutation. I’ve...
  27. madman

    Gonadal recovery in men with prolactinomas on cabergoline

  28. madman

    Erectile Dysfunction: The TRUTH About Cialis, Viagra & Testosterone

    * Hormones are only one component of a complex system involving vascular function, neurologic signaling, metabolic health, medications, and psychosocial factors. Listen closely! 5:00 ED vs Low Testosterone: Why They’re Not the Same In Part 2 of this conversation on men’s health and...
  29. madman

    Erectile Dysfunction Isn’t Just About Sex — Here’s What It’s Really Telling You

    In this episode of Hormones and Hope, Dr. Chhaya Makhija begins a two-part series on men’s health and erectile dysfunction with urologist and sexual medicine specialist Dr. Katherine Klos. Key Takeaways: * What are the medical causes of erectile dysfunction? * Can erectile dysfunction...
  30. madman

    The $49 Test That Saves Lives: Dr. Mohit Khera’s Warning for Men Over 40

    You would mean the $49 test which includes the most critical blood marker free testosterone tested using the most accurate assay the gold standard Equilibrium Dialysis! https://www.discountedlabs.com/testosterone-free-dialysis-and-total-ms I agree Dr. Khera is a true powerhouse in the...
  31. C

    TRT which causes pelvic floor pain (CPPS)

    6'2", 246 lbs (111kg) male (with a decent frame). I have a 3mm L4-S1 protrusion, but my main issue is severe anal/perineal burning (CPPS) that is directly triggered by TRT (also have back pain). I’ve tried various esters (test p/e/c/nebido) and injection frequencies (daily/eod/weekly/biweekly)...
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