trt

  1. K

    Has TRT reversed osteopenia, or osteoporosis?

    I just got a bone scan and have osteopenia in spine and dual femurs. I’m not on TRT. I have been doing weight-bearing exercises for years and been on calcium, etc. not sure if it’s from chemo or testosterone that’s been in the 350 range the past four years or so I was wondering if TRT...
  2. madman

    A Study of XYOSTED® for Testosterone Replacement in Male Adolescents With Conditions Associated with Deficiency or Absence of Endogenous Test

    https://www.bcm.edu/healthcare/clinical-trials/h-56187 Description An Open-Label Multiple-Dose, 52-Week Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of XYOSTED® for Testosterone Replacement in Male Adolescents (ages: 12 to <18 years) With Conditions Associated with Deficiency...
  3. madman

    Testosterone Therapy: Does New Evidence Warrant Broader Prescribing?

    * Bhasin noted that, like fellow academics and endocrinologists, he has historically been cautious around testosterone therapy. “In the last 5 years or so, we’ve learned a lot more, and I’ve changed my position,” he said. “On one side, it’s very rigid, and on the other, it’s touted as the cure...
  4. madman

    New official German Men’s Health Portal Section on Testosterone Deficiency

    https://www.linkedin.com/pulse/new-official-german-mens-health-portal-section-fcpfe Prof Dr med Dr hc Michael Zitzmann, MD. PhD, FRSM https://www.maennergesundheitsportal.de/themen/testosteronmangel-bei-maennern/
  5. madman

    SERMs over Testosterone Therapy: Superior Safety with Comparable Efficacy in Secondary Hypogonadism

    https://endo2026.endocrine.org/searchGlobal.asp Background Testosterone therapy is widely used for male hypogonadism but suppresses gonadotropins, reducing intratesticular testosterone and impairing spermatogenesis. These effects contribute to testicular atrophy, infertility, and increased...
  6. S

    Boxer on TRT with persistent fatigue/brain fog - low-normal E2, mediocre free T, no gym battery

    I’ve searched this forum and several others trying to find a situation that matches mine, but I haven’t found anything that really lines up, so I’m posting here hoping someone sees something obvious that I’m missing. I’m a boxer with 15+ years of training. For the last 4 years I’ve been battling...
  7. madman

    Testosterone replacement therapy and cardiovascular safety in older men: lessons from TRAVERSE and beyond

    * TRT does not increase MACE risk in men with confirmed organic hypogonadism when titrated to physiological levels. Non-MACE signals warrant vigilance rather than contraindication. Metabolic optimisation should precede TRT in functional hypogonadism. Individualised monitoring and careful patient...
  8. madman

    Can Men Take Testosterone After Prostate Cancer? New Study Says This

    In this episode, Dr. Brandon and Dr. Morgentaler talk about navigating sexual differences in relationships, the latest evidence supporting testosterone therapy after prostate cancer treatment, and practical ways couples can rebuild intimacy and sexual confidence during recovery. 00:00 –...
  9. madman

    LifeMD Announces Exclusive Collaboration to Launch Direct-to-Patient Self-Pay Program for XYOSTED® (testosterone enanthate) Injection

    * The program will launch in July 2026 and will initially be available in 37 states. * Life MD’s platform is designed to remove those barriers by combining clinically appropriate virtual evaluation, lab-based diagnosis, ongoing clinical support, and access to home delivery of an FDA-approved...
  10. madman

    Marius Pharmaceuticals Applauds FDA’s Proposed Testosterone Labeling Updates as a Turning Point for Men’s Health

    https://mariuspharma.com/news/marius-pharmaceuticals-applauds-fdas-proposed-testosterone-labeling-updates-as-a-turning-point-for-mens-health/ The FDA’s second major labeling update in 16 months — after its February 2025 removal of the cardiovascular boxed warning — marks a historic...
  11. A

    Anastrozole worriment urgent.

    Starting in December 2025 I began a 160mg TRT weekly protocol that has HCG 250mg monday wednesday friday however the clinic had closed for approximately two weeks. I ended up taking a test booster called EVL Test that has the following Vitamin D3- 50 Mcg Vitamin B6- 11mg Magnesium 160 mg...
  12. madman

    Long-Term Skeletal and Body Composition Responses to Androgen-Based Therapies in Male Hypogonadism

    * We studied 394 men aged 22–76 years with primary (n=132), secondary (n=96), or functional (n=166) hypogonadism treated for up to 7 years with T-gel (1–3 actuations/day; n=168), TU 1000 mg intramuscularly every 10–14 weeks (n=142), or hCG 1500 IU subcutaneously twice weekly (n=84). *...
  13. madman

    Dr Mohit Khera Offers a Clinician Update on Testosterone Therapy for Men’s Health

    Born for this! https://www.renalandurologynews.com/features/mohit-khera-testosterone-therapy-for-men/ https://www.excelmale.com/threads/once-weekly-hcg-helps-preserve-fertility-in-men-on-testosterone-therapy-largest-study-yet.34086/
  14. L

    How to counter Immunity drop during TRT

    My Test dosage is 70 Mg/ week split in to two doses. I don’t have high estrogen or symptoms. But my immunity has dropped considerably and I am getting frequent cold/cough/UTI while on TRT. Had to take antibiotics and takes a long time to cure. I believe this is because of TRT. In terms of life...
  15. L

    HCG used indefinitely for a long time

    I currently take 1500 IU of HCG weekly Split into 3 shots of 500IU each and they are taken on Monday/Wednesday/friday. I also take testosterone year round and add in some other compounds. I take HCG solely for testicular size and the benefits I feel on it for libido and increasing penile...
  16. madman

    Summary of the EAU Guidelines on SRH recommendations for the measurement of total T and biochemical diagnosis of male hypogonadism

    * Immunoassays show acceptable accuracy for total T but are unreliable for free T measurement [19,20]. * As previously noted, the main limitation of free T evaluation in clinical practice is the poor accuracy of the available immunoassay methods [19]. To address this issue, several...
  17. madman

    Interview with Shalender Bhasin, MBBS, author of Testosterone Treatment in Prostate Cancer Survivors With Hypogonadism: A Randomized Clinical Trial

    Another one under the belt for Dr. Bhasin! https://edhub.ama-assn.org/jn-learning/audio-player/19061825 Interview with Shalender Bhasin, MBBS, author of Testosterone Treatment in Prostate Cancer Survivors With Hypogonadism: A Randomized Clinical Trial, and Peter C. Albertsen, MD, author...
  18. M

    TRT doubts 8 weeks in

    Hi guys, I am 8 weeks into trt, enanthat 40mg e3.5d subQ. Started low, as I was having a history 6 years ago with trt and elevated hematocrit. My results came in and I was shocked. HCT already came back at 52.2 and total T at 11.8ng/ml which was surprisingly high as well for that low dose...
  19. madman

    What You Don't Know About Testosterone

    Shalin Shah explains how testosterone serves as a key biomarker for overall health and outlines common symptoms that indicate testing is needed: including fatigue, muscle loss, and decreased libido. He emphasizes that while lifestyle factors like diet, sleep, and exercise are foundational...
  20. S

    MCT TRT issue anyone? Possible side effects?

    Hi team. Been on a TRT journey for a year. One of the biggest takeaways I've learned here is to stay the coarse, try not to change dosage and timing often, things will stabilize. But, in doing so I am feeling off, constantly...its been going on for 6 months. After months of trial and...
  21. madman

    CDC HoST-TT Certification for Siemens Healthineers Total Testosterone Test Expands Patient Access to Gold Standard Equivalent Results

    * The CDC’s Clinical Hormone Standardization Programs standardize the total testosterone assay so that results are accurate, comparable, and clinically meaningful wherever they are performed * By calibrating assays to a common reference method and enforcing stringent performance criteria, CDC...
  22. madman

    Why Pfizer Stopped Selling DEPO®-TESTOSTERONE in Canada

    Was bound to happen sooner or later! There was still some limited back stock floating around. I am sitting on numerous vials and have some Delatestryl left to boot. All we have know are slim pickings the two generics Hikma TE and Taro TC. Even then everyone is going to be stuck with the Taro...
  23. T

    TRT dosing help

    0.30 ml enanthate E3D put me at 742 trough free T PMOL, Total T 30nmol and shbg 8 (single digit shbg always) I felt really good on this dose but then i lowered to 0.20 E3D, and i started getting a bit of brain fog, less drive and motivation. My urologicst doesen’t keep people over the reference...
  24. madman

    Nebido Is Coming to Canada: What It Means for Testosterone Supply and Shortages

    Nothing ground breaking here as the majority of men will stick with the go to medium acting esterified TC/TE! Flexible dosing and easily titrated are key here let alone weekly injections whether once weekly or more frequently take the cake when it comes to taking advantage of the anabolic...
  25. madman

    Advanced Equilibrium Dialysis for Free Testosterone: A New Standard in HRT Testing

    48-Position Custom Deep Well Plate For In Vitro Equilibrium Dialysis at a 1:1 Sample to Buffer Volume Ratio * CDC scientists have developed a new design for a multi-well dialysis microplate for equilibrium dialysis. The unique design accommodates a 1:1 buffer to sample ratio and provides...
  26. G

    Thinking about starting TRT. Advice?

    I’m on the fence about starting TRT. A little backround about me. 31(M) at roughly 16% BF with a healthy overall lifestyle. I workout 4x per week, eat healthy for the most part, and sleep 8 hours per night. Supplements I’m currently taking are a multivitamin, vitamin D, magnesium, zinc, and...
  27. madman

    TRT and Sleep Apnea Risk: Why Testosterone Therapy May Increase OSA Risk—Especially in Men Under 50

    Abstract INTRODUCTION AND OBJECTIVES: The relationship between testosterone replacement therapy (TRT) and obstructive sleep apnea (OSA) is an emerging field of interest. TRT is typically contraindicated in patients with severe uncontrolled OSA, but our previous research has shown OSA risk...
  28. madman

    hCG on TRT: How Adjunct Therapy May Improve Strength, Endurance, and Energy in Active Men

    Abstract INTRODUCTION AND OBJECTIVES: Human chorionic gonadotropin (HCG) is commonly added to testosterone therapy (TTh) to preserve testicular function. In clinical experience, many men with testosterone deficiency express a preference for adjunctive HCG with TTh. We performed a...
  29. madman

    TRT-Induced Azoospermia: Why hCG and Gonadotropin Levels Don’t Predict Sperm Recovery

    Abstract INTRODUCTION AND OBJECTIVES: The use of testosterone replacement therapy (TRT) among men is rising leading to an increasing number of men with TRT induced azoospermia from hypothalamic-pituitary-gonadal (HPG) axis suppression. Human chorionic gonadotropin (HCG) is used to mitigate...
  30. madman

    Clomid for Low Testosterone: Why It May Lower HDL and Affect Cholesterol Despite Boosting Hormones

    Abstract INTRODUCTION AND OBJECTIVES: Clomiphene citrate (CC) is increasingly used off-label to treat male hypogonadism while preserving gonadal function. CC has been associated with dyslipidemia in women treated for ovulatory dysfunction, and preliminary data from our institution previously...
  31. madman

    Normal Testosterone Isn’t Enough: How SHBG Hides Low Free T in Older Men

    Abstract INTRODUCTION AND OBJECTIVES: Total testosterone (TT) measurement is widely used to diagnose male hypogonadism (MH). However, TT may be normal despite androgen deficiency when sex hormone-binding globulin (SHBG) is elevated, a condition often associated with ageing and chronic...
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