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  1. madman

    SUB-Q VS INTRAMUSCULAR TESTOSTERONE IN MALE HRT: PHARMACOKINETICS, SAFETY, TOLERABILITY, AND CLINICAL IMPLICATIONS

    * Esterification of testosterone increases its lipophilicity and enables its incorporation into oil-based vehicles to form a depot after injection. The duration of exposure depends not exclusively on the systemic half-life of free testosterone but also on release of the ester from the depot, its...
  2. S

    Hematocrit creeping up

    I’ve been a long term low dose guy that responds very well to testosterone. I do 60mg per week and normally end up 750ng day seven trough. Anyhow my hematocrit had been 46-48 for many years. The last cbc showed hematocrit 50.3, hemoglobin 16.2 and rbc at 5.2. 50 is the top of labcorps range now...
  3. C

    Genetics & replacement / optimization therapy?

    ***Long post incoming.*** I'm interested in who may have had any genetic testing done and if it ultimately led to discovering the "optimal" protocol, whatever that may be. I'm not a fan of the term, but it probably best describes things at this point. TRT prescribed by my PCP for two years...
  4. madman

    Hims Expands Testosterone Care with Injectable and Oral TRT, Its Largest Men’s Health Launch to Date

    https://investors.hims.com/news/news-details/2026/Hims-Expands-Testosterone-Care-with-Injectable-and-Oral-TRT-Its-Largest-Mens-Health-Launch-to-Date/default.aspx Starting today, Hims is closing that gap, providing eligible customers access to three new treatment options, including: Two...
  5. C

    Normal total T, low free T/high SHBG at 51 year old - worth a TRT trial?

    I’m Tony, 51. I have fatigue, low libido, brain fog, and reduced recovery despite consistent CrossFit and home-gym training for 15+ years. I’m around 215 lb after losing approximately 20 lb with tirzepatide over the last 3+ months. Repeat labs show: • Labcorp: total T 646 ng/dL; direct free T...
  6. madman

    Lipocine Announces Health Canada Approval of TLANDO® for Testosterone Replacement Therapy

    Great new for Canadian as there will be 3 options now (Jatenzo, Kyzatrex and Tlando) for men interested in using the newer oral TU formulations! https://ir.lipocine.com/2026-10-07-Lipocine-Announces-Health-Canada-Approval-of-TLANDO-R-for-Testosterone-Replacement-Therapy SALT LAKE CITY, Oct...
  7. M

    Why Did Doubling My Dose 4x My Free T? Breaking Down My Daily Injection Lab Results

    @ 100mg per week spread over daily injections = 500ish total; free = 65; SHGB = 23 @ 125mg per week spread over daily injections = 650ish total; free = 117; SHBG = 21 @ 200mg per week spread over daily injections = 1300ish total; free = 275; SHBG = 17 At 200 per week my hematocrit and...
  8. madman

    Hegseth's Testosterone Plan: A Doctor Who Treats Veterans Responds

    19:43 What an 'optimal' testosterone level really is Dr. Mark Gordon * Optimal health is between the 50th and 75th percentile of the range The average man today is walking around with meaningfully less testosterone than his grandfather had at the same age — and the fix the military is...
  9. T

    Is the amount of pheromones your body secretes directly correlated to the amount of testosterone you inject?

    Does the body only secrete a certain amount of pheromones regardless of the amount of your dosage or do you secrete more the more you inject?
  10. madman

    Hypogonadism - Myths and Realities

    Learning Objectives HPG Axis Physiology Key TTh Takeaways https://www.adventhealth.com/institutes/research/team/john-tillet-md-1939
  11. madman

    ED Predicts Heart Attacks Better Than Chest Pain: The 2 Tests to Ask For

    Dr. Tobias Kohler * There T level at that point when they are healthy is a very important number. Most of the time it is going to be 500 or so, right? There are some published T levels per decade of life and it does go down. It's pretty rare to get above 1000 naturally considering that as a...
  12. madman

    Beyond Injections and Gels: The Oral Pill Transforming Testosterone

    Shalin Shah In this episode of the Bioenergetics Beat Podcast, Heather Gray sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to discuss oral testosterone replacement therapy, the growing crisis of testosterone deficiency in men, and why this hormone has been unfairly stigmatized...
  13. B

    Why would TRT reduce semen volume

    I've read lots of posts that TRT reduces semen volume. My question is why would it do so? Is this well understood?
  14. madman

    Anabolic Steroids & Men’s Health: The Science, Risks & Realities of Sexual Function, Fertility, Heart Health & Hormones

    Going out to all the bros caught up on that more T is better mentality bulls**t! T is a threshold hormone! 22:18 Superphysiologic Testosterone Levels Internationally recognized experts in men's health—Dr. Alex Tatem, Dr. Mohit Khera, and Dr. Kevin Campbell joined Dr. Rena Malik to unpack...
  15. madman

    Association of testosterone and testosterone replacement therapy with atrial fibrillation

    * Treatment should be embedded in structured monitoring of hematocrit, blood pressure, renal and hepatic function, and cardiac rhythm, and coupled with active management of coexisting obesity, sleep apnea, diabetes, hypertension, and dyslipidemia, each of which independently influences AF risk...
  16. madman

    Understanding Testosterone and Myth-Busting with Dr. Abraham Morgentaler

    He mentions Bhasin's latest paper when speaking about TT vs FT! https://www.excelmale.com/threads/hormonal-profiles-of-men-with-highly-elevated-shbg-and-primary-testicular-dysfunction-support-free-hormone-hypothesis.34791/ 45:34-58:43 (TT vs FT, estradiol/AI, hematocrit) In this...
  17. madman

    WHEN ENDOCRINOLOGY REACHES BEYOND THE CONSULTATION ROOM

    Dr. Zitzmann * Testosterone is surrounded by myths, expectations and fears. It is neither a universal fountain of youth nor simply a dangerous “doping hormone”. It is an essential hormone whose deficiency can have significant consequences—but diagnosis and treatment must always be based on...
  18. madman

    Individualizing Injectable TRT in Primary Care: Pharmacokinetics, Symptom Stability, Safety Monitoring, and Injection Frequency

    * Once treatment is indicated, clinicians should document the testosterone ester, dose, concentration, route, injection interval, timing of the last injection, and timing of bloodwork. Without that context, testosterone results can be misleading...
  19. madman

    T Does Not Drive Prostate Cancer: Presenting the New Framework of Androgen Adequacy vs Inadequacy

    Two heavy weights in the field drop a big one! * Sixty-five years after the landmark publication by Huggins and Hodges, it was discovered that their principal conclusion that T injections “activated” PCa even in hormonally intact men was based on erratic acid phosphatase results in a single...
  20. A

    Thoughts on these results (33 Male)

    These were taken in June. I used to be on TRT and my total was in the 400s. Ive been off for about over 4 years now and here are my results. I feel ok if I get a good night's sleep but mentally I was still better on TRT. Im not in an awful place mentally but definitely takes more management...
  21. madman

    LTR Pharma Expands Men’s Health Platform Through Exclusive KYZATREX® Pilot Commercialisation Agreement in Australia

    * Following the evaluation period, LTR Pharma has a right to negotiate an exclusive licence for KYZATREX in Australia. KYZATREX is not registered by the TGA; initial patient access will be facilitated through the Special Access Scheme, which enables medical practitioners to prescribe unapproved...
  22. J

    Trt advice needed please

    Currently on TRT. Great muscle gains and generally feel good but im suffering badly from erectile issues and libido. Currently taking 100mg of T cypionate per week split into daily injections. This has taken my testosterone level to 39 over the last 3 months. However my estrogen level is 185...
  23. madman

    Miller School Trial Tests Testosterone Therapy in Men With Low-Risk Prostate Cancer

    * “Active surveillance is about safely managing low-risk prostate cancer while preserving quality of life,” said Sanoj Punnen, M.D., professor of urologic oncology at the Miller School and DSUI vice chair of research. “For some men, maintaining quality of life may include testosterone...
  24. K.pietera

    need TRT in belgium - stopped BalanceMyHormones

    Hi friends, I have been on TRT for 8 years. Started with hertoghe clinic in Belgium but after 2 years I quit because they where expensive as hell and they can't provide the optimal protocol. So I switched to BalanceMyHormones for 6 years and for me personally it was the best I could get. I...
  25. madman

    Managing testosterone deficiency in primary care: an international expert consensus

    Some of the true heavyweights here! Introduction General practitioners (GPs) are often the first point of contact for men with testosterone deficiency (TD), however, TD has traditionally been considered a condition reserved for specialists [1]. Various specialty societies have published...
  26. madman

    Impact of Hypogonadism on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Male Individuals

    https://endo2026.endocrine.org/fsPopup.asp?efp=RkVJT0NBS1UyNTg5OA&PresentationID=1845616&rnd=0.7988844&mode=presInfo Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major public health concern, affecting approximately one third of the adult population. While...
  27. madman

    Estrogen and testosterone in the management of osteoporosis

    Dr. Snyder nuff said! 00:00-29:16 32:57-54:12
  28. madman

    Off-label testosterone therapy is associated with higher long-term cardiovascular risk in men

    * Despite these limitations, this study provides a large-scale, head-to-head comparison of men receiving testosterone therapy with vs without evidence of hypogonadism, with up to 10 years of follow-up, race/ethnicity stratification, rigorous propensity-score matching, and complementary modelling...
  29. madman

    What to know about testosterone screening

    Dr. Stanton Honig. Been at this for decades! In today's health headlines: what to know about the recent changes to testosterone risk and use labels, what to know about testosterone screening, and how lifestyle habits could impact testosterone.
  30. S

    post anastrazole crash on a pfs sufferer? Need Help.

    TL;DR: Long PFS history since Nov 2023 (fin crash → partial recovery on TRT for over a year, doing well). In June 2026 added anastrozole (3-4 doses over ~3 weeks) to a 300mg test + masterone protocol → crushed my E2. Dropped test dose from 200mg to 100mg/week in July to try to fix the T:E2 gap...
  31. M

    What deodorant actually works for guys on TRT?

    Has anyone found a deodorant that actually works on TRT? Mine stopped working about 3 months after starting Cypionate.

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