hypogonadism

  1. madman

    CDC HoST-TT Certification for Siemens Healthineers Total Testosterone Test Expands Patient Access to Gold Standard Equivalent Results

    * The CDC’s Clinical Hormone Standardization Programs standardize the total testosterone assay so that results are accurate, comparable, and clinically meaningful wherever they are performed * By calibrating assays to a common reference method and enforcing stringent performance criteria, CDC...
  2. madman

    Why Pfizer Stopped Selling DEPO®-TESTOSTERONE in Canada

    Was bound to happen sooner or later! There was still some limited back stock floating around. I am sitting on numerous vials and have some Delatestryl left to boot. All we have know are slim pickings the two generics Hikma TE and Taro TC. Even then everyone is going to be stuck with the Taro...
  3. madman

    Nebido Is Coming to Canada: What It Means for Testosterone Supply and Shortages

    Nothing ground breaking here as the majority of men will stick with the go to medium acting esterified TC/TE! Flexible dosing and easily titrated are key here let alone weekly injections whether once weekly or more frequently take the cake when it comes to taking advantage of the anabolic...
  4. madman

    Advanced Equilibrium Dialysis for Free Testosterone: A New Standard in HRT Testing

    48-Position Custom Deep Well Plate For In Vitro Equilibrium Dialysis at a 1:1 Sample to Buffer Volume Ratio * CDC scientists have developed a new design for a multi-well dialysis microplate for equilibrium dialysis. The unique design accommodates a 1:1 buffer to sample ratio and provides...
  5. madman

    Enclomiphene vs Clomiphene for Low Testosterone: Do They Work the Same for Boosting Testosterone, LH, and FSH?

    Abstract INTRODUCTION AND OBJECTIVES: Clomiphene citrate has been used off-label to treat male hypogonadism by stimulating endogenous gonadotropin secretion. Enclomiphene, the trans-isomer of clomiphene, is increasingly prescribed, but comparative data remain limited. We aimed to assess whether...
  6. madman

    TRT and Sleep Apnea Risk: Why Testosterone Therapy May Increase OSA Risk—Especially in Men Under 50

    Abstract INTRODUCTION AND OBJECTIVES: The relationship between testosterone replacement therapy (TRT) and obstructive sleep apnea (OSA) is an emerging field of interest. TRT is typically contraindicated in patients with severe uncontrolled OSA, but our previous research has shown OSA risk...
  7. madman

    hCG on TRT: How Adjunct Therapy May Improve Strength, Endurance, and Energy in Active Men

    Abstract INTRODUCTION AND OBJECTIVES: Human chorionic gonadotropin (HCG) is commonly added to testosterone therapy (TTh) to preserve testicular function. In clinical experience, many men with testosterone deficiency express a preference for adjunctive HCG with TTh. We performed a...
  8. madman

    Clomid for Low Testosterone: Why It May Lower HDL and Affect Cholesterol Despite Boosting Hormones

    Abstract INTRODUCTION AND OBJECTIVES: Clomiphene citrate (CC) is increasingly used off-label to treat male hypogonadism while preserving gonadal function. CC has been associated with dyslipidemia in women treated for ovulatory dysfunction, and preliminary data from our institution previously...
  9. madman

    Normal Testosterone Isn’t Enough: How SHBG Hides Low Free T in Older Men

    Abstract INTRODUCTION AND OBJECTIVES: Total testosterone (TT) measurement is widely used to diagnose male hypogonadism (MH). However, TT may be normal despite androgen deficiency when sex hormone-binding globulin (SHBG) is elevated, a condition often associated with ageing and chronic...
  10. madman

    Azoospermia on TRT? hCG vs Clomid for Fertility—Why Sperm Recovery May Not Depend on FSH

    Abstract INTRODUCTION AND OBJECTIVES: To evaluate FSH recovery rates and sperm production in men with testosterone therapy (TTh)-induced azoospermia treated with hCG alone versus hCG combined with clomiphene citrate, focusing on men with severely suppressed baseline FSH. METHODS...
  11. madman

    Why Normal Testosterone Levels May Still Cause Symptoms: The Hidden Role of CAG Repeat Length in TRT

    Abstract INTRODUCTION AND OBJECTIVES: The preferred treatment for hypogonadism, testosterone replacement therapy (TRT), has a varying efficacy that is currently not understood. This observation may be explained by polymorphism of the androgen receptor (AR), a ligand-binding transcription factor...
  12. madman

    Once-Weekly hCG Helps Preserve Fertility in Men on Testosterone Therapy (Largest Study Yet)

    Abstract INTRODUCTION AND OBJECTIVES: Testosterone therapy (TTh) is known to suppress spermatogenesis, but combination TTh with human chorionic gonadotropin (hCG) has been shown to maintain spermatogenesis in a small 26-patient case series. That study did not account for prior fertility (or...
  13. madman

    Dr Jeff Foster - Director of Men’s Health at Voy/Manual (UK)

    https://www.joinvoy.com/experts/dr-jeff-foster https://www.h3health.co.uk/ https://www.joinvoy.com/trt https://www.excelmale.com/threads/british-society-for-sexual-medicine-guidelines-on-male-adult-td.27188/...
  14. madman

    Boosting Male Fertility:The Impact of Gonadotropin Therapy on Hypogonadotropic Hypogonadism

    * Despite these limitations, the findings of this review provide valuable guidance for clinical practice. The consistent benefit of combined hCG and FSH therapy in inducing spermatogenesis and achieving pregnancy supports its role as a first-line treatment for men with HH and infertility. Future...
  15. madman

    Testosterone Replacement Therapy - Experts Discuss - safety (hematocrit/CVD), efficacy, formulation selection

    * Panelists address the risk of polycythemia associated with testosterone therapy, particularly injectable formulations, and emphasize the importance of monitoring hematocrit changes relative to baseline values rather than absolute thresholds alone Moderated by Manoj Monga, MD, FACS...
  16. madman

    Vasectomy Reversal Leads to Couple's Restored Fertility with Dr. Larry Lipshultz

    https://www.urologyhealth.org/healthy-living/urology-care-podcast/sexual-health-podcasts/vasectomy-reversal-leads-to-couples-restored-fertility-with-dr-larry-lipshultz
  17. madman

    Defining clinically relevant responses in erectile function: an SMSNA position statement

    https://academic.oup.com/jsm/article/23/3/qdaf392/8507270
  18. madman

    Comparative review of the PK and PD of testosterone therapies in T2DM

  19. madman

    Sex Hormone Influences on Venous Thrombotic and Cardiovascular Risk

    https://www.nejm.org/doi/abs/10.1056/NEJMra2202438
  20. madman

    One of the most stigmatized and misunderstood hormones in medicine

    Testosterone levels have dropped more than 25% over the past two decades — and the downstream effects on brain health, cardiovascular function, energy, and libido are only beginning to be understood. Leslie sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to go deep on one of the most...
  21. Nelson Vergel

    Delayed Puberty in Boys: When Is “Wait and See” No Longer Safe?

    Curated By Nelson Vergel | ExcelMale.com | Updated April 2026 Key Takeaways • Age 14 is the medical deadline for boys, not a suggestion. If a boy has not reached a testicular volume of 4 ml by age 14, it is time to see a pediatric endocrinologist, not to keep waiting. • Most...
  22. madman

    The Other Half of Fertility: Understanding Male Infertility

    https://audioboom.com/posts/8890570-the-other-half-of-fertility-understanding-male-infertility Think infertility is just a women's issue? Think again. In this eye-opening episode of the Modern Parenthood Podcast, Dr. Dorette Noorhasan is joined by Dr. Andrew Sun. A trained urologist who...
  23. madman

    Controversies with Testosterone Replacement Therapy

    Dr. Khera of course! * if you prescribe testosterone there are five controversies you have to know about! Mohit Khera, MD, MBA, MPH Professor of Urology F. Brantley Scott Chair in Urology Director, Laboratory for Andrology Research Faculty Group Practice Medical Director Baylor College...
  24. madman

    Experts react to FDA’s potential pathway for TRT label expansion

    Following the FDA’s announcement on a potential pathway to expand testosterone replacement therapy (TRT) labeling,1 leading experts in men’s health shared their perspectives on what this development could mean for patients and clinical practice.
  25. madman

    FDA Signals Potential Expansion of Testosterone Therapy to Treat Low Libido in Idiopathic Hypogonadism

    https://www.ajmc.com/view/fda-signals-potential-expansion-of-testosterone-therapy-to-treat-low-libido-in-idiopathic-hypogonadism https://www.fda.gov/news-events/press-announcements/fda-takes-step-forward-testosterone-therapy-men The U.S. Food and Drug Administration today is taking an...
  26. madman

    Gonadal recovery in men with prolactinomas on cabergoline

  27. madman

    Shalin Shah of Marius Pharmaceuticals - Past, present, and future of testosterone therapy

    At the Clinical Application of Longevity Medicine 2026 conference, cardiologist and longevity physician Dr. Abid sits down with Shalin of Marius Pharmaceuticals — makers of Kyzatrex, the FDA-approved oral testosterone — for a candid conversation about the past, present, and future of...
  28. madman

    Erectile Dysfunction: The TRUTH About Cialis, Viagra & Testosterone

    * Hormones are only one component of a complex system involving vascular function, neurologic signaling, metabolic health, medications, and psychosocial factors. Listen closely! 5:00 ED vs Low Testosterone: Why They’re Not the Same In Part 2 of this conversation on men’s health and...
  29. madman

    Erectile Dysfunction Isn’t Just About Sex — Here’s What It’s Really Telling You

    In this episode of Hormones and Hope, Dr. Chhaya Makhija begins a two-part series on men’s health and erectile dysfunction with urologist and sexual medicine specialist Dr. Katherine Klos. Key Takeaways: * What are the medical causes of erectile dysfunction? * Can erectile dysfunction...
  30. madman

    The $49 Test That Saves Lives: Dr. Mohit Khera’s Warning for Men Over 40

    You would mean the $49 test which includes the most critical blood marker free testosterone tested using the most accurate assay the gold standard Equilibrium Dialysis! https://www.discountedlabs.com/testosterone-free-dialysis-and-total-ms I agree Dr. Khera is a true powerhouse in the...
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