Testosterone and Type 2 Diabetes Program: Key to Testosterone Benefits in Men at Risk of T2D

madman · 2026-08-08T09:56:53-0500

* "One takeaway message from this is that ongoing engagement in a structured weight management program is extremely important for maintenance and the benefit of testosterone."

Testosterone treatment may improve body composition, glucose metabolism and sexual desire in some older men at high risk of type 2 diabetes, but an ENDO 2026 study by Gary Wittert, MBBch, MD, finds these benefits require engagement in a lifestyle program.

madman · 2026-08-08T09:57:32-0500

Thread 'Effects of 4 Years Testosterone Treatment on Glycemia, Anthropometry, Sexual Function and Safety'

Aug 1, 2026

* T4DM RUNON sub-study extended the T4DM randomized, double-blind, placebo-controlled trial (n=1007) by 2 years, for a total of up to 4 years of treatment, without ongoing enrolment in the lifestyle program. Eligible and consenting participants (n=121) continued their original masked allocation to intramuscular testosterone undecanoate (1000mg 3 monthly) or placebo.

* In men with prediabetes or early T2DM, in the subgroup with continuing blinded T treatment for up to 4 years there were diminishing glycemic benefits and durable improvements in anthropometry and sexual...