hypogonadism

  1. madman

    What a thorough male fertility evaluation actually looks like

    Must listen for anyone interested in fertility especially when using exogenous T! * Why lab work and semen analysis interpretation require true infertility expertise In this exciting episode of Fertility and Other F Words, Dr. Amy Pearlman and Dr. Larry Lipshultz are joined by two leaders...
  2. madman

    What men should know about their hormone health

    Metabolic health expert Shalin Shah from Marius Pharmaceuticals explains how testosterone affects energy, focus, weight and aging. https://play.cdnstream1.com/s/graymedia/kara-s-cures-57e324/kara-s-cures-men-s-healt-3ef1d6
  3. madman

    How Oral Testosterone Will REVOLUTIONIZE TRT

    Shalin Shah is the CEO of Marius Pharmaceuticals, where he leads the development of novel therapies for testosterone deficiency and metabolic health. His background spans finance, private equity, and pharmaceutical strategy, with a focus on patient-centered innovation and education around...
  4. madman

    The 1st FDA approved oral Testosterone: Meet Kyzatrex®

    Founder, CEO, and visionary behind Marius Pharmaceuticals, the company that brought Kyzatrex to market—the first FDA-approved oral testosterone replacement therapy. With a background in private equity and investing, he moved into biotech to solve a long-standing problem in hormone health: making...
  5. madman

    Why the FDA Is Finally Reversing Course on Testosterone

    In this episode, Dr. Morgentaler & Dr. Brandon talk about whether testosterone can be improved naturally, why supplements and diet fall short, and how outdated FDA policies and misconceptions continue to shape testosterone treatment today. Chapters 00:38 Testosterone Myths and Realities –...
  6. madman

    Health Canada Approves JATENZO®

    Another oral TU option for Canadians! Should be available soon! * Importer / Innomar Strategies Inc. Oakville, ON L6L 0C4 https://www.innomar-strategies.com/ https://pdf.hres.ca/dpd_pm/00082762.PDF Tolmar International Ltd. Dublin 2, Ireland D02 T380 Date of Initial...
  7. madman

    Endocrine Society -Meet the 2026 Laureates

    https://endocrinenews.endocrine.org/meet-the-2026-laureates/ The Endocrine Society is proud of its many distinguished members who lead the global endocrine community by advancing scientific knowledge, providing exemplary care, teaching the next generation of endocrinologists, and improving...
  8. madman

    Pill vs. Needle: The science behind the new oral therapy replacing injections

    Men are living, on average, 7 years less than women. According to Shalin Shah, CEO of Marius Pharmaceuticals, the medical community has ignored a cause for decades due to stigma, "gym bro" stereotypes, and outdated science. In this episode, Daniel Robbins sits down with Shalin Shah to reveal...
  9. madman

    The Real Reason Your Erections Are Getting Worse With Age

    Dr. Anand Patel is a GMC-registered GP and one of the UK's leading experts in men's health, specialising in healthy sexual function, testosterone deficiency, and male fertility. Studies are showing that men are dissatisfied with their penis size and commonly experiencing a wide array of sexual...
  10. madman

    What Men Get Wrong About Sex, Libido & Erectile Dysfunction

    04:23 Free Vs Total Testosterone * I think most health professionals do not check free testosterone levels * I think that most experts acknowledge that free testosterone is very important, right? I think they do. If you look at some of the data, the data would show that the free testosterone...
  11. Kaizerox

    I need help with my TRT

    Hello, I have been lurking on this forum, looking at other cases and learning a little from them, but now I would like some guidance from you about my situation. At the age of 24, I was diagnosed with secondary hypogonadism, but it was a problem I had had before that age. (I related my symptoms...
  12. madman

    Fix Testosterone’s Outdated Label?

    https://www.medscape.com/viewarticle/fda-listened-estrogen-will-they-now-fix-testosterones-2026a10000na?form=fpf Rachel Rubin, MD Hello, everyone. I’m Dr Rachel Rubin, and we’re here for another episode of Sex Matters. I am thrilled to introduce two of my major mentors. I can’t say enough...
  13. madman

    Dr. Morgantaler Debunks Myths about Testosterone & Prostate Cancer

    Finally Dr. Geo interviews the grandmaster of T! Free Testosterone * in my experience if its <100 pg/mL (10 ng/dL) and the guy has symptoms I'll treat them If you’re 55, 60, 65+ and dealing with low energy, low libido, ED, or you’ve been told testosterone therapy (TRT) is dangerous for...
  14. madman

    The Health Crisis of Low Testosterone

    Shalin Shah is the CEO of Marius Pharmaceuticals and widely known as The Metabolic CEO. He’s a leading voice in metabolic health and hormone therapy innovation, and one of the strongest advocates working to destigmatize testosterone for both men and women. In this episode, we go deep into...
  15. madman

    Hypogonadism in men with prolactinoma: Diagnosis treatment, and management of persistent hypogonadism

    * Despite effective medical therapy with dopamine agonists and prolactin normalization, over 20 % of men with prolactinomas will remain with hypogonadism. * There are two suggested mechanisms for hypogonadism: central suppression of the hypothalamic-pituitary-gonadal axis caused by elevated...
  16. madman

    menMD - Kyzatrex® (testosterone undecanoate) twice-daily oral capsule

    * $179 per bottle (120 capsules) https://menmd.com/product/kyzatrex/
  17. madman

    New post-marketing clinical study for potential label expansion evaluating KYZATREX® (TU) CIII capsules in men ages 65–80 with hypogonadism

    * The trial will also evaluate KYZATREX’s labeled titration protocol alongside a simplified once-daily dosing regimen, an important consideration for older adults who may benefit from more streamlined, easy-to-follow treatment plans...
  18. madman

    Oral TU Formulations (Andriol®, JATENZO®,TLANDO®, KYZATREX® for T Therapy

    * Oral TRT, particularly testosterone undecanoate (TU), offers notable convenience. TU is absorbed via the lymphatic system, bypassing first-pass hepatic metabolism, making it a promising agent for TRT. Its absorption, however, is influenced by dietary factors, such as lipid intake, thus the...
  19. madman

    Is Erectile Dysfunction a Sign of Infertility?

    Is erectile dysfunction (ED) a sign of male infertility? Not always — but it can sometimes point to underlying issues that affect both sexual health and fertility. In this video, Dr. Mike Hsieh, a urologist specializing in male reproductive health, and Dr. Jamie Stanhiser, a fertility specialist...
  20. madman

    Real-World Outcomes and Safety of T Therapy: A Longitudinal, Retrospective Cohort Study of Over 9,000 Men

    S**t load of men injecting strictly sub-q! Yes it is an effective modality for many! * 8,517 were treated with sub-cutaneous testosterone injections (89.20%) * Significant increases were observed in all 8 QoL domains, e.g., +1.26 points (95% confidence interval [CI]: 1.01 to 1.43) for...
  21. madman

    TRT myths, metabolic risk, and the role of the urologist

    * Mills emphasizes that TRT is frequently misunderstood as “supplementation” rather than true hormone replacement * I actually think that the supra-physiologic dosing is probably where things get a little bit muddy; is that we don't have great longitudinal data. Very few studies, uh, out of...
  22. madman

    Moments with Dr. Arthur “Bud” Burnett: Johns Hopkins Pioneer on Men's Health and Lifestyle Choices

    * Testosterone doesn't always correct erectile dysfunction Moments with Dr. Arthur “Bud” Burnett:Johns Hopkins Pioneer, ED Researcher, First BlackProfessor, Global Men’s Health Author & Innovator Chapters 00:00 Introduction to Men's Health 01:30 Understanding Sexual Dysfunction and...
  23. Nelson Vergel

    Oral Testosterone Therapy: A Complete Guide to Jatenzo, Tlando, Kyzatrex, and Emerging Options

    By Nelson Vergel | ExcelMale.com | Updated December 2025 Summary: This comprehensive guide examines the development of FDA-approved oral testosterone products—Jatenzo, Tlando, and Kyzatrex—which overcome the liver toxicity problems of earlier oral formulations by using testosterone...
  24. madman

    How testosterone went from prostate cancer villain to potential ally

    * Even more surprisingly, doctors are testing a new approach in certain men with prostate cancer called bipolar androgen therapy, which switches testosterone levels between very low and very high. The idea is to use testosterone itself as a weapon to confuse and kill cancer cells that have...
  25. madman

    What online TRT clinics get wrong about men’s cardiovascular health

    * However, Mills argues that safety alone is not the benchmark for quality care. Men presenting with symptoms of low testosterone often have multiple comorbidities—poor sleep, sedentary lifestyle, suboptimal diet, or uncontrolled CV risk factors—that should be addressed alongside or even before...
  26. madman

    Helen L. Bernie, DO, MPH, outlines clinical management of hypogonadism in fertility-desiring men

    * Finally, Bernie noted unresolved controversies in the field, including the optimal duration of fertility-preserving therapies, long-term outcomes of hybrid regimens combining testosterone with hCG, and best practices for sperm recovery after prolonged testosterone exposure. She emphasized the...
  27. madman

    Manopause vs Menopause: why we are not so different

    * This speech by Dr Jeff Foster, NHS GP Partner and Director of Men's Health at Voy/Manual highlights the critical under-diagnosis of low testosterone (often termed "manopause") and its profound impact on overall male health. The speaker, who runs the UK's largest private testosterone clinic...
  28. madman

    Testosterone replacement therapy (TRT), and what the latest evidence really tells us about safety, cancer risk, and healthy ageing in men

    Hitting the nail on the head here! * The panel unpacks why “normal ranges” don’t fit every individual, highlighting genetic differences in androgen receptor sensitivity (CAG repeats) and the need to tailor treatment to symptoms and biology rather than numbers alone. 4:20-6:07 * so we have...
  29. madman

    Testosterone a Hormone for Health and Survival in Men

    Listen closely here! 11:55-12:13 * you only need testosterone levels up for about 4-6 hrs in the day to produce an effect which works through the androgen receptor, the androgen receptor is present in every cell in the body so its not just a sex hormone it is a health hormone Another...
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