hypogonadism

* Testosterone plays an important role in the maintenance of male skeleton. Most studies of testosterone therapy have demonstrated some degree of improvement in BMD * Based on elegant mechanistic studies (discussed below), the current thinking is that both testosterone and estradiol are...

In part one of this men’s health series, Dr. Eve Glazier and Jesse Mills, MD, health sciences clinical professor of urology and director of the Men’s Health Clinic at UCLA Health, examine how symptoms such as erectile dysfunction can offer important insights into overall health. They discuss why...

In this episode of Pearls & Perspectives, host Amy Pearlman, MD, is joined by renowned male reproductive specialists Larry I. Lipshultz, MD, and Dolores J. Lamb, PhD, to discuss the science, clinical value, and future of the male infertility laboratory. Drawing on decades of collaboration in...

https://www.bcm.edu/healthcare/clinical-trials/h-56187 Description An Open-Label Multiple-Dose, 52-Week Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of XYOSTED® for Testosterone Replacement in Male Adolescents (ages: 12 to <18 years) With Conditions Associated with Deficiency...

* Bhasin noted that, like fellow academics and endocrinologists, he has historically been cautious around testosterone therapy. “In the last 5 years or so, we’ve learned a lot more, and I’ve changed my position,” he said. “On one side, it’s very rigid, and on the other, it’s touted as the cure...

How do you protect your prostate, recognize the early signs of erectile dysfunction, and separate medical facts from internet myths? In this episode, Tom (he/him) sits down with Dr. Arthur Burnett (he/him), renowned Johns Hopkins urologist, researcher, and one of the pioneers behind the science...

https://www.linkedin.com/pulse/new-official-german-mens-health-portal-section-fcpfe Prof Dr med Dr hc Michael Zitzmann, MD. PhD, FRSM https://www.maennergesundheitsportal.de/themen/testosteronmangel-bei-maennern/

https://endo2026.endocrine.org/searchGlobal.asp Background Testosterone therapy is widely used for male hypogonadism but suppresses gonadotropins, reducing intratesticular testosterone and impairing spermatogenesis. These effects contribute to testicular atrophy, infertility, and increased...

* The findings support the Endocrine Society’s recommendation that direct IAs should not be used in clinical practice. https://endo2026.endocrine.org/fsPopup.asp?PresentationID=1845305&mode=presInfo Free testosterone (FT) is widely used in clinical diagnosis, management, and research of...

In this episode, Dr. Brandon and Dr. Morgentaler talk about the FDA's groundbreaking testosterone label changes, the evolving evidence on testosterone therapy and prostate cancer, and how quality of life should factor into treatment decisions for men with advanced disease. Time stamps...

2 Pathophysiology of Anabolic Steroid-Induced Hypogonadism 2.1 Central and Peripheral Mechanisms of HPG Axis Suppression 2.2 Mechanisms Contributing to Delayed Recovery 3 Overview of Post-Cycle Therapy Approaches 4 Pharmacology of Clomiphene Citrate 5 Clinical Evidence of Clomiphene...

Authors Gal Saffati, MD David E. Hinojosa-Gonzalez, MD Mohit Khera, MD, MBA, MH Now in its 45th installment, the AUA Update Series is renowned for delivering high-quality lessons to practicing urologists, fellows and residents. All content is developed by internationally recognized...

Sanoj Punnen, MD, highlights the importance of assessing and managing cardiovascular risk when initiating androgen deprivation therapy for patients with prostate cancer.

The FDA's proposed narrowing of the testosterone therapy prostate cancer contraindication to metastatic disease only reflects current clinical evidence, opening the door to testosterone therapy in appropriately selected men with treated localized prostate cancer or on active surveillance, with...

In this episode of AUANews Inside Tract, host Dr. Mark Edney speaks with Dr. Helen Burnie about the FDA’s proposed updates to testosterone therapy labeling and what they could mean for urologists, patients, and the broader field of men’s health. The discussion explores new evidence on...

More T is better they say LOL! Hate to burst your bubble but the reality of T physiology is thresholds, plateaus, and diminishing returns not a linear "more testosterone is better" dose-response. 36:25 Why Higher Testosterone Can Be So Addictive for Muscle Gain Chapters: 00:00 Why...

* TRT does not increase MACE risk in men with confirmed organic hypogonadism when titrated to physiological levels. Non-MACE signals warrant vigilance rather than contraindication. Metabolic optimisation should precede TRT in functional hypogonadism. Individualised monitoring and careful patient...

In this episode, Dr. Brandon and Dr. Morgentaler talk about navigating sexual differences in relationships, the latest evidence supporting testosterone therapy after prostate cancer treatment, and practical ways couples can rebuild intimacy and sexual confidence during recovery. 00:00 –...

* The program will launch in July 2026 and will initially be available in 37 states. * Life MD’s platform is designed to remove those barriers by combining clinically appropriate virtual evaluation, lab-based diagnosis, ongoing clinical support, and access to home delivery of an FDA-approved...

https://mariuspharma.com/news/marius-pharmaceuticals-applauds-fdas-proposed-testosterone-labeling-updates-as-a-turning-point-for-mens-health/ The FDA’s second major labeling update in 16 months — after its February 2025 removal of the cardiovascular boxed warning — marks a historic...

In conclusion, men with lower testosterone concentrations had higher risk of cancer death, and men with mid-range SHBG or luteinising hormone concentrations had lower risk. Low testosterone concentrations were associated with risk of any fatal or non-fatal incident cancer. Men with lower SHBG or...

This gives us an OPTIMIZATION WINDOW of 11.8-15.9 ng/dL * over 20 years of the Millennium's clinical observation of patients we have identified that patients within this upper-mid quartile range demonstrate better energy, enhanced cognitive performance, improved metabolic stability and better...

* This narrative review integrates randomized and real‑world evidence on TRT‑associated AF, AKI, and PE, translates these signals into practical guidance for patient selection and safety monitoring, and outlines key methodological and mechanistic priorities for future research. In contemporary...

In this episode of Better Edge, Robert Brannigan, MD, president of the American Society for Reproductive Medicine (ASRM), discusses key updates from ASRM’s 2026 committee opinion on fertility preservation. Dr. Brannigan outlines what urologists should know about early identification, rapid...

In this episode, Shalin Shah, CEO of Marius Pharmaceuticals and a passionate advocate for testosterone education, shares insights on the misunderstood hormone that impacts both men and women. We dive into myths, testing protocols, treatment options, and the importance of early diagnosis for...

* The survey found that the most commonly reported symptoms over the past year (among those tested) included low energy or fatigue (48%), poor sleep (47%), reduced motivation (34%), low sex drive (28%), mood changes or irritability (27%), brain fog (26%), weight gain (26%), and reduced muscle...

* We devised a formula to calculate predicted total testosterone concentrations, based on meta-analyses of individual participant data from 21,074 men, aged 17-99 years, from nine cohort studies in Australia, Europe and North America of community-dwelling men with testosterone measured using...

* Dr. Jessica Colon-Franco is inspired by providing answers to physicians and patients using mass spectrometry. Dr. Jessica Colon-Franco is the Section Head of Clinical Biochemistry and Medical Director of the Special Chemistry Laboratory at Cleveland Clinic. Her clinical laboratory...

https://www.hhs.gov/press-room/fda-requests-updates-testosterone-therapy-labeling.html The U.S. Department of Health and Human Services, through the U.S. Food and Drug Administration (FDA), announced today that it is requesting updates to the prescribing information for testosterone...

Must listen here! Most men think erectile dysfunction is a bedroom problem and low testosterone is just a fact of getting older. This roundtable makes the case that both are early warning lights for your heart, your metabolism, and your long-term health and that ignoring them can cost...

Powerhouse in the field! In this episode, Dr. Brandon and Dr. Morgentaler welcome Dr. Abdulmaged Traish, world-renowned hormone researcher and professor emeritus at Boston University, to talk about his incredible journey from growing up in a poor village with no electricity or running...