Hcg + Trt

HCG (human chorionic gonadotropin) is used alongside testosterone replacement therapy to preserve testicular size, maintain intratesticular testosterone, and support fertility by mimicking luteinizing hormone. Common protocols range from 250 to 500 IU two to three times per week, with clinical data showing 500 IU every other day can maintain sperm parameters during TRT. Discussions in this tag cover real dosing experiences, subq vs IM injection, timing around testosterone shots, effects on libido and mood, sourcing after the 2020 biologics reclassification, and how men adjust the balance between testosterone and HCG over time.
  1. Tremonti22

    HCG & Gyno / High E2

    I have a ton of respect for Mr Vergel and I know he said HCG doesn’t raise E2 that much, but I’ve been on TRT 1.5 years / 150 mg twice week (75 x2) & recently got on 500 iu twice weekly HCG. I have never felt better, finally no foggy head and I have all the benefits of the trt, HOWEVER, horribly...
  2. T

    Doctor that will prescribe HCG in So. Il.

    Need a Doctor that will prescribe HCG in So. Il. My Doctor is getting me test. cyp. 200mg/10ml, but will not prescribe HCG. Do not won't a clinic like Defy or Primebody, would like local. When I try your Doctor finder, I get this error. We're sorry, you are not allowed to proceed Our server...
  3. 3

    will vasectomy negatively affect my hormones?

    My wife and I conceived our first child through Clomid and just recently another via HCG Monotherapy. While children are truly a blessing, I think we’re done, lol. I’m considering a vasectomy for birth control, but we’re concerned about how that might affect my overall health/hormones. I’m...
  4. L

    18 Year-Old With Testicular Atrophy

    Hello everyone, I am 18 years old and 1 year ago run a 7 week cycle with transdermal DHT (like Andractim). At the seventh week i stopped because i saw my testicles shrinking. I was an idiot.. It's been 1 year since i stopped but my testicular size and sperm has not recovered. My hypothesis is...
  5. O

    HCG need question

    On TRT and Anastrazole, curious if HCG will help with fat loss and perhaps other benefits. No testicular issues and no need for fertility so curious if taking HCG makes any sense. Thanks!
  6. O

    HCG & Leydig Cell Disensitization

    As per the title I am hoping some knowledgeable gents on the forum can shed some light on the reality of HCG use causing Leydig cell disensitization and if it does what that means long term. I’m currently using 250IU eod and have been reading on other forums, from people purporting to be...
  7. A

    Fat neck and Face - is this Test or HCG related?

    Since going off Sustanon and moving to a Test E and HCG strategy my face has changed quite drastically - despite losing 9 pounds of weight this month my work shirts are really uncomfortable around the neck and the skin there is looking leathery and loose, face is puffy as well. I have never had...
  8. Z

    What is a good level of SHBG?

    So it seems I probably have wore out my welcome with questions on this site. No one really seems to answer anymore. But I am going to ask another and hopefully someone responds. Was wondering if having SGHB be in the mid to high 40s is better then having it in the low 20s I get labs don’t tell...
  9. J

    HGH with TRT and HCG

    Looking for any feedback if anybody is using HGH with their TRT & HCG program.
  10. D

    Rapid dissolve oral HCG and other HCG questions

    Hey guys! I have been accustomed to injectable HCG for a long time. The pharmacy that I use switched to rapid dissolve tablets (specifically an hcg/b12 blend tablet) and assure me it works just as well. Does anyone have any experience?? The dosage of the tablets is 500u and I am to take it...
  11. D

    HCG dosage affected by low SHBG?

    Dr. just wrote me a script for hcg. Been on Test. Cyp. 100 mg once a week. After my 6 week lab, he said I could try twice a week. Seems to help the peaks. At my 6 week labs, my TT was 440, Free T was 110, SHBG was 22.5, and Estradiol was 35.7. Dr. gave me a script for 1500 units a week of...
  12. S

    Cycle HCG?

    Hey guys, I was wondering if HCG needs to be cycled? I just started a week ago with 500iu’s twice a week. If it does need to be cycled, for how long off and on? And as far as dosage, is 250iu eod better than 500 e3.5 days? My main concern is desensitizing receptors and possibly permanently...
  13. S

    Just started HCG

    Hey guys, so I just started HCG today after about 6 months on just testosterone cyp and anastrozol. My protocol before the hcg was 40mg test cyp eod along with daily anastrozol ranging from .25 to .75 mg. Total test was 991 and sensitive e2 was 34 the day after injection. Felt good, however I...
  14. Z

    Yet another fertility, ancillary case following long term TRT

    Hey everyone. I know a lot of this topic has been covered a few times, but since every case is different I figured I would start an original post and invite input from the entire community. Ill put as much detail as possible. A brief bio: 40yo retired military, Registered dietitian and...
  15. P

    HCG and Prostate Heath

    What is the relationship between using low dose HCG (200IU twice a week) for example, on the the prostate while on HRT? I have tried searching for articles and have got various answers. Does it lead to prostate hypertrophy or not?
  16. L

    Is Anastrazole truly necessary?

    Hi All, I was on a really bad TRT regimen for many many years (inject 300mg once every 3 weeks). I did not take HCG with my dose either. I was never monitored nor had blood panels. I was taking this dose from 2010 until 2018. I never bothered to get blood panels or check my hematocrit or E2 or...
  17. H

    Has HCG potency changed OR do bodies change in the way they react

    I am taking much less HCG than I did just 2 years ago with more of an effect and more side effects. When I originally came to defy, I was dialed in eventually to .28 mg of test EOD and .25mg anastrozole 3X a week. I was told by Crisler originally to take 100ius of HCG with that. After a follow...
  18. R

    HCG WHILE ON TRT

    I'm going to be starting TRT soon but I have a question about HCG. Is it needed right away? I am looking to preserve my fertility since I'm 26 years old while on TRT but I am not going to try have any kids any time soon. Is it possible I could start HCG when the times comes when I want to try to...
  19. H

    Has anyone else had a change in how they react to HCG - confirmed by Defy

    I've had some challenges over the past 9 months on getting dialed back in again which have been mainly due to HCG. I am ready to either cut it down to a minimal part of my protocol or go back to using it daily as opposed to keeping it EOD. When I first came to Defy, Dr Crisler suggested 100 ius...
  20. B

    HCG is the problem....

    Hi folks. Some of you have probably read some of my other post. But here is a brief overview. I was having high E side on my starting protocol of 80mg of T and 500iu of HCG every 3.5 days. I tried lowering my T dose to 60mg every 3.5 days, and all that did was lower my E2 from 75 to about 70...
  21. Z

    Sweet spot

    So I am now my 2nd week into not taking my AI. Anyways Sunday morning when I woke up, I woke up with like the biggest urge to have sex ‘like I felt like I was 14 going through puberty’ even my wife after said “I was almost to overbearing” mind you my entire life I have never been one to be a...
  22. C

    There's no regions in my nethers...

    When I first started TRT I was given HCG with my protocol. It has never seemed to agree with me for some reason or another so I stopped taking it. I recently tried to incorporate it back in my protocol but it was making me feel like shit at just 250 iu every 3.5 days and had to stop. I suspect...
  23. E

    Starting TRT with Defy

    Feel free to move this post if needed. I didn’t see a place for logs and this seemed to be the best place. Yesterday I had my new-patient consult with Dr Calkins of Defy Medical. Man, Defy is great and Dr Calkins was awesome. He took the time to answer all of my questions and I felt like he...
  24. J

    Unable to get HCG... Is HMG an option to prevent testicular atrophy?

    I am in Spain, 50 years old. I've been having low T symptoms for a few years, but I was able to cope with it because it was only a "performance drop", until a couple of years ago, when severe erectile dysfunction appeared and I could no longer have an acceptable sex life, in addition to a...
  25. M

    HCG dosage- How to calculate it

    I am about to undertake my HCG maiden voyage (adding to my TRT regime) and could use help in assuring my calculations are correct. I will be taking 250iu of HCG twice a week (T & Th) as I understand the the math, since I have 5000iu of freeze dried HCG, I will dilute it with 5ml of...
  26. S

    HCG/HGH high Estrogen! Need advice please

    Hello all I've used HCG with no Test just to see if I could increase weight loss, energy levels and gain muscle and I have! I stated at 275IU ed for 3 months but had issues with nipple sensitives so I'm down to 200IU ed my nipples are fine now but DHT is going on. I'm looking into topical...
  27. B

    New to T/HCG - Some Questions

    Hey guys, I'm not sure if this is the correct place for this but I thought I'd try to get some feedback on my situation. I've experimented some form of hormone replacement in the past: Pellets - expensive and the Dr. seemed to be about $$$/Too difficult to keep up with Clomid - higher T numbers...
  28. 3

    Crashed My Estadiol - Help!!

    This post comes as no surprise to those that saw my post that my doc put me on 1mg/day of anastrazole because my estradiol was at 64. I’m now at less than 5 and I feel horrible. What on earth do I do now? I’m currently taking .25ml testosterone cyp. and 400iu’s HCG on M/W/F.
  29. T

    Timeline of HCG's effects on testosterone levels

    I see a lot of info out there regarding the timeline and serum levels of testosterone after injecting, but am having a hard time finding similar info for HCG. Anyone know how long it takes for an injection of HCG to impact T levels? Is there a similar onset/peak for increased T or is it...
  30. B

    Testosterone and Fertlity

    So, I am 27M and I have been diagoned with 1.21ng/ml Total T. My GP says he will do my tests again to confirm and then send me to the specialist for therapy(perhaps). My major concern is fertility(I want kids someday!).I've read that we need to combne TRT with HCG to maintain fertility and have...
  31. B

    HCG and fertility

    So, I am 27M and I have been diagnosed with 1.21ng/ml Total T. My GP says he will do my tests again to confirm and then send me to the specialist for therapy(perhaps). My major concern is fertility(I want kids someday!).I've read that we need to combne TRT with HCG to maintain fertility and have...
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Hcg + Trt

Hcg + Trt HCG (human chorionic gonadotropin) is used alongside testosterone replacement therapy to preserve testicular size, maintain intratesticular testosterone, and support fertility by mimicking luteinizing hormone. Common protocols range from 250 to 500 IU two to three times per week, with clinical data showing 500 IU every other day can maintain sperm parameters during TRT. Discussions in this tag cover real dosing experiences, subq vs IM injection, timing around testosterone shots, effects on libido and mood, sourcing after the 2020 biologics reclassification, and how men adjust the balance between testosterone and HCG over time.

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