Switching from cream to injection

Spandex

New Member
If you were to switch from cream which has approximately one day half life to cypionate injection, would it make sense to do a higher first dose injection to “preload” ?

For example, if your protocol was 50mg twice a week, do 100mg first shot and then 3-4 days later come in with the 50mg and so on.

Asking this because if your natural production is lowered from the cream, would be nice to avoid an extended trough that could occur while you wait for multiple injection cypionate half life’s to build up.
 
Assuming your goal plan is 100 mg Testosterone Cypionate twice a week (50 mg every 3.5 days) you can use the following to achieve steady state within a week

First week
Monday: 50 mg
Wednesday: 50 mg
Friday: 30 mg

Subsequent weeks
Monday: 50 mg
Thursday: 50 mg

This will produce something like this. The first 3 peaks are Mon-Wed-Fri of the first week, then you get pretty stable thereafter.
1709318722940.webp


All this is assuming you'll be starting with a relative low level.

Now take my advice: don't take advice from me
 
If you were to switch from cream which has approximately one day half life to cypionate injection, would it make sense to do a higher first dose injection to “preload” ?
There are no shortcuts in the TRT world. Steady blood levels are achieved by being consistent with your dosages, any deviation, change in dosages will pause, delay how long it takes to reach steady blood levels, because your body is constantly trying to adapt to the changes.
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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