These large doses produce more estrogen and larger testosterone and estrogen spikes and can create large swings in levels, your levels swing out of a range that good for you causing erections and libido suffer.
High Free T almost always means high Free E2, Free T converts over to Free E2, so if Free T is high, chances are so to is Free E2. When you inject smaller more frequent doses, these spikes are smaller so the swings are smaller and therefore levels more stable.
Systemlord what info have you found on Free E2 spikes that I can look over? So far I’ve only seen it mentioned by forumites.
Predict estradiol, DHT, and free testosterone levels based on total testosterone
This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.
Enter your total testosterone value to see predictions
Results will appear here after calculation
A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.
Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.
The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.
Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.
DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038