Question: With low shbg, can higher dosages and with only 1-2 times a week create sexual problems?

equel

Active Member
Anyone with experience? With SHBG around maybe 18-20, and if u inject doses over 50mg, could that mess things up which gives you low libido and/or ED?

If so, is this due to high free T and free E spikes or what is exactly going on?
 
These large doses produce more estrogen and larger testosterone and estrogen spikes and can create large swings in levels, your levels swing out of a range that good for you causing erections and libido suffer.

High Free T almost always means high Free E2, Free T converts over to Free E2, so if Free T is high, chances are so to is Free E2. When you inject smaller more frequent doses, these spikes are smaller so the swings are smaller and therefore levels more stable.
 
These large doses produce more estrogen and larger testosterone and estrogen spikes and can create large swings in levels, your levels swing out of a range that good for you causing erections and libido suffer.

High Free T almost always means high Free E2, Free T converts over to Free E2, so if Free T is high, chances are so to is Free E2. When you inject smaller more frequent doses, these spikes are smaller so the swings are smaller and therefore levels more stable.

Systemlord what info have you found on Free E2 spikes that I can look over? So far I’ve only seen it mentioned by forumites.
 
Systemlord what info have you found on Free E2 spikes that I can look over? So far I’ve only seen it mentioned by forumites.

Dr Crisler has the most forward thinking position on Low SHBG and Free E though even he is perhaps not as forward as real guys on the forum that are dealing with it, successfully.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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