These large doses produce more estrogen and larger testosterone and estrogen spikes and can create large swings in levels, your levels swing out of a range that good for you causing erections and libido suffer.
High Free T almost always means high Free E2, Free T converts over to Free E2, so if Free T is high, chances are so to is Free E2. When you inject smaller more frequent doses, these spikes are smaller so the swings are smaller and therefore levels more stable.
Systemlord what info have you found on Free E2 spikes that I can look over? So far I’ve only seen it mentioned by forumites.