By Nelson Vergel | ExcelMale.com | Updated December 2025 When evaluating testosterone levels, most men focus exclusively on total testosterone—a single number that tells only part of the story. What many don't realize is that a protein called...
Are you tired of painful intramuscular injections and wondering if there's a more comfortable way to administer your testosterone replacement therapy? For decades, intramuscular (IM) injections have been the standard method for testosterone...
By Nelson Vergel | ExcelMale.com | Updated December 2025 Introduction Should you take an aromatase inhibitor with testosterone replacement therapy? This question has sparked considerable debate in men's health circles, with some clinics routinely...
By Nelson Vergel | ExcelMale.com | Updated December 2025 Summary: This comprehensive guide examines the development of FDA-approved oral testosterone products—Jatenzo, Tlando, and Kyzatrex—which overcome the liver toxicity problems of earlier...
Many men begin testosterone replacement therapy expecting their sexual function to improve across the board—better libido, stronger erections, enhanced satisfaction. And while TRT often delivers significant benefits for desire and overall sexual...
Summary: The TRAVERSE trial, a landmark FDA-mandated study involving over 5,200 men, has definitively concluded that testosterone replacement therapy (TRT) does not increase the risk of major cardiovascular events like heart attacks, strokes, or...
Clascoterone 5% Topical Solution for Male Androgenetic Alopecia Overview Clascoterone 5% topical solution represents what could be the first genuinely novel therapeutic mechanism for male pattern hair loss in over three decades. Cosmo...
Testosterone is a controlled substance in the US, specifically a Schedule-III controlled substance (in all but one State), and this includes any form of testosterone including injectable, transdermal, patches, pellets, and any compound or product...
FDA Approval of Testosterone Therapy for Women: An Analysis of Historical Failures, Regulatory Hurdles, and a Path Forward Executive Summary The landscape of testosterone therapy presents a stark gender disparity: while over 31 FDA-approved...
I collected questions and answers posted on ExcelMale.com in the last 10 years about the use of human chorionic gonadotropin in men who want to prevent loss of testicular size and fertility while on testosterone replacement therapy or that want...
@Nelson Vergel We need you here! https://www.fda.gov/patients/fda-expert-panels/fda-expert-panel-testosterone-replacement-therapy-men-12102025 Location: FDA White Oak Campus, 10903 New Hampshire Ave., Building 31, Great Room, Silver...
What's the best HCG dosing protocol for men on TRT? Whether you're using HCG to maintain fertility, prevent testicular atrophy, or preserve intratesticular testosterone, the dosing frequency matters. Should you inject daily, every other day, or...
