Testosterone side effects

New Hair Loss Treatment Safer than Finasteride?: Clascoterone 5% Topical Solution

Dec 18

Clascoterone 5% Topical Solution for Male Androgenetic Alopecia Overview Clascoterone 5% topical solution represents what could be the first genuinely novel therapeutic mechanism for male pattern hair loss in over three decades. Cosmo...

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US Federal and State Regulations on Testosterone and HCG

Dec 17

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Testosterone is a controlled substance in the US, specifically a Schedule-III controlled substance (in all but one State), and this includes any form of testosterone including injectable, transdermal, patches, pellets, and any compound or product...

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Key Historical Failures and Lessons Learned from Attempts to Get a Testosterone Product FDA-Approved for Women

Dec 12

FDA Approval of Testosterone Therapy for Women: An Analysis of Historical Failures, Regulatory Hurdles, and a Path Forward Executive Summary The landscape of testosterone therapy presents a stark gender disparity: while over 31 FDA-approved...

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HCG Use in Men on TRT or as Monotherapy: Over 200 Questions and Answers

Dec 05

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I collected questions and answers posted on ExcelMale.com in the last 10 years about the use of human chorionic gonadotropin in men who want to prevent loss of testicular size and fertility while on testosterone replacement therapy or that want...

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Upcoming FDA Expert Panel on Testosterone Replacement Therapy for Men

Dec 02

@Nelson Vergel We need you here! https://www.fda.gov/patients/fda-expert-panels/fda-expert-panel-testosterone-replacement-therapy-men-12102025 Location: FDA White Oak Campus, 10903 New Hampshire Ave., Building 31, Great Room, Silver...

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HCG DOSE FREQUENCY FOR MEN - FERTILITY & TESTICULAR ATROPHY

Nov 15

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What's the best HCG dosing protocol for men on TRT? Whether you're using HCG to maintain fertility, prevent testicular atrophy, or preserve intratesticular testosterone, the dosing frequency matters. Should you inject daily, every other day, or...

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Options for Delayed or Absent Orgasms Despite Stimulation in Men

Nov 15

Experiencing delayed orgasm or anorgasmia on TRT? Many men on testosterone therapy report difficulty reaching climax despite normal erections and libido. This frustrating issue is more common than most realize—and it's often treatable once you...

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The Relationship Between Testosterone Therapy and Atrial Fibrillation: A U-Shaped Curve Hypothesis

Nov 14

Does testosterone therapy increase the risk of atrial fibrillation? The relationship between TRT and heart arrhythmias is more nuanced than headlines suggest. Recent research points to a U-shaped curve—both very low AND very high testosterone...

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Dr. Shalender Bhasin: Optimizing the Diagnosis and Treatment of Hypogonadism 2025

Nov 07

Nelson's house u heard it here first! Dr. Shalender Bhasin! * over the past 4 decades he has become a global leader in the biology of androgens, sarcopenia and aging related functional decline, his research has shaped clinical guidelines, its...

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The Truth About Performance Enhancing Drugs

Nov 04

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Bradley D. Anawalt Professor and Vice-Chair of Medicine Department of Medicine School of Medicine University of Washington Disclosure Summary: Consultant for the United States Anti-Doping Agency Note from Nelson: Listen at 31...

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PCT After Anabolics: Clomid versus hCG + Clomid

Nov 03

Objectives To evaluate the clinical necessity and optimal pharmacological strategy for post-cycle therapy (PCT) in recreational anabolic-androgenic steroid (AAS) users with normal pre-cycle reproductive profiles. Subjects and Methods This...

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Best HCG Dose for Men on TRT: Two Studies That Used HCG with Testosterone

Oct 28

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What's the optimal HCG dose to preserve fertility and testicular size while on testosterone replacement therapy? Two landmark studies provide critical guidance for men seeking to maintain reproductive function during TRT. Research from Baylor...

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038