What’s the general consensus on AI’s here?

Unless you have certain cancers, you really don't need an AI. For those that have difficulty reducing or stopping AI, it's probably because the way you are dosing your T is causing hormone spikes that are causing you to not feel well. The AI may mask the spikes, but it isn't actually helping you. I was formerly in the AI camp and even though my e2 crashed over and over again, I couldn't find a way to get off of them. It wasn't until I smoothed out my hormones enough by going to 2x daily compounded cream that I was finally able to discontinue the AI. Others may succeed simply by injecting at least EOD. My e2 sits around 80 now, but I feel the best I've ever felt on TRT. My body gets pissed if I even try zinc or calcium d-glucarate to lower e2. My e2 is where it should be at the higher level.

Do you apply the cream to your scrotum? Don’t forget that DHT basically minimizes high E2 symptoms. So a person with an E2 of 80 while applying cream to their scrotum is not the same thing as a person with an E2 of 80 with normal DHT levels. And I’m not attacking you or anything, I’m a cream user myself and apply a good amount to my scrotum. Just saying it’s not apples to apples.
 
Thanks to the Nicholites for chiming in. While you show your sources on the dangers of AI's used in low doses if needed, can you also show sources showing that running dht at supraphysiological levels is safe long term? TIA
 
did you actually document that 1mg dose you say took you from 66 to 10?

Document, as in speak with the doc about it? If that's the meaning of "document" then obviously yes. If "document" means do I have the lab results handy for a show-and-tell, then no...but I can get them from the doc.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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