TRT Review - Low SHBG, High E2, Crashing Libido

rdrg-queiroz

New Member
Hey guys,

Looking for some advice on my TRT protocol. I'm 21, had testicular cancer last year (orchiectomy + chemo, now in remission). Been on TRT for about 3 months, trying to dial it in since I'm still having issues.

Here's the situation:
Complaint: Zero libido, some anhedonia, water retention.
Protocol: 62.5mg Sustanon E3.5D (so 125mg/week), plus 500 IU HCG twice weekly (1000 IU total).
Labs (trough, 12h pre-injection):
- Total T: 921 ng/dL
- Free T: 294 pg/mL
- E2: 68 pg/mL
- SHBG: 15.9 nmol/L
- Prolactin: 12 ng/mL
- TSH: 2,49 mcUI/mL
- T4: 1,32 ng/dL
- T3: 133 ng/dL
- HCT: 53.3%

Background:
Tried Clomid initially, crashed hard with emotional sides and libido. HCG monotherapy didn't do much. Now on TRT + HCG, but libido is still MIA. Doc isn't super knowledgeable about TRT nuances, so I'm trying to figure this out myself.

My Thoughts:
I'm thinking my low SHBG is causing issues. The Sustanon is a blend of short and medium esters, so I'm probably spiking and crashing hard. My E2 seems high relative to my SHBG, even though Total T isn't crazy high.

The Question:
Given the low SHBG and high E2, does it make sense to switch to more frequent injections (EOD or daily) with a lower overall dose to stabilize things? Any other suggestions on how to dial this in and get my libido back? Also, any thoughts on the HCG dose?

Thanks in advance for any input!
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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