High SHBG, Low Free T, and Libido - Can you help me?

Commission__ · Apr 10, 2023

200mg test cyp a week, twice a week injection M/TH

0.125mg Arimidex with injection twice a week. 0.25mg total a week

SHBG 49.9

1259 total test

Free T 26.4 pg/mL

Estradiol ,sensitive 45.4 pg/mL

I felt my e2 was low on this and I had brain fog. Irritable, and just depressed. Libido was good

160mg test cyp a week, EOD injections

No AI

54.6 SHBG

909 total test

Free T 13.8 pg/mL

66.6 pg/mL e2

Zero Libido or interest in girls, felt ok but not interested in sex at all

200mg Test cyp a week, EOD injections

1000iu HCG a week EOD injections

0.125mg Arimidex EOD

SHBG 48.6

>1500 Total test

Free T 34.7 pg/mL

Estradiol, Sensitive 47.4 pg/mL

Felt brain fog here again, and just irritable and angry. Teeth gritting all the time, and hateful. Felt jealous all the time and just not fun to be aroune

I have no libido unless I take AI, but I feel terrible and am so moody and edgy. If I drop the AI, I have no motivation or drive to do anything. I need help, what should I try out?

Systemlord · Apr 10, 2023

Since you seem sensitivity to estrogen sides, maybe target a Free T level at 18-20 pg/mL. I would also add in Cialis which can lower E2 by favoring testosterone over estrogen, by change the ratios of the two hormones.

Cialis has many health benefits outside it’s intended use.

Definitely focus on smaller more frequent dosing regimens. Due to your three most recent labs and Free T results, your optimal dosage is somewhere between 160<->200 mg.

So 180 mg split up 3 times a week, 5 mg Cialis and no AI.

Years ago I was able to get anastrozole at 0.050 from Hollandale pharmacy through Defy Medical.

Commission__ · Apr 10, 2023

Anything past 75 for estradiol, I have to take an AI. I feel uneasy and just not right. I should’ve mentioned. Hcg also helps me with libido and sensitivity

Thank you for responding

Belekas · Apr 10, 2023

Have you tried smaller, I'd say normal TRT dosages like 70-100mg/week for example?

madman · Apr 11, 2023

Systemlord said:
Since you seem sensitivity to estrogen sides, maybe target a Free T level at 18-20 pg/mL. I would also add in Cialis which can lower E2 by favoring testosterone over estrogen, by change the ratios of the two hormones.

Cialis has many health benefits outside it’s intended use.

Definitely focus on smaller more frequent dosing regimens. Due to your three most recent labs and Free T results, your optimal dosage is somewhere between 160<->200 mg.

So 180 mg split up 3 times a week, 5 mg Cialis and no AI.

Years ago I was able to get anastrozole at 0.050 from Hollandale pharmacy through Defy Medical.

Far from a given that tadalafil is going to have a significant impact on lowering estradiol.

You have no clue where his trough FT level truly sits as he most likely never even tested it using an accurate assay (Equilibrium Dialysis or Ultrafiltration).

He has altered SHBG.

Looking over his labs TT/FT even without reference ranges good chance he used Labcorps standard immunoassay for TT and the piss poor direct immunoassay for FT.