Trouble with high dose?

Runner

New Member
I started TRT about 10 months ago after attempting every conservative treatment I could try and failing to get results. The honeymoon phase at a conservative dose was amazing, but then I had to switch providers due to my PCP moving. The new providers put me on 200mg once a week with routine monitoring. My numbers all looked "good" but nothing else did. I put on about 15lbs of weight (not mostly muscle), my sleeping got worse, and my overall feeling of wellness went down. Working out 5-6 days a week and eating extremely well did not change body type or cause weight loss (I'm at the top of a "healthy weight" and would prefer to be 15lbs lighter). My Estrodiol was at the high end of "normal" so I tried DIM for a few months and still did not see results. My doctor then gave me Anastrozole which does not seem to be helping either. After three weeks, I told my provider we had to make a change since I felt pretty much identical to my pre TRT self. I am fairly in tune with my body, and I suspect that the high dose may be doing something bad that may not be showing on bloodwork (though it did clearly elevate my Estradiol). We decided to cut the dose down to 140 and see if that helps. Has anyone else had an issue like this and tried reducing dosage?
 
What was the dosing during your conservative honeymoon phase? 70mg+ dosages at one time make me feel like my levels are 3000...then by the trough I will feel better and numbers will look good but the beginning of the week I feel like the dose is a bit much.
 

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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