Thoughts on latest labs

Pringle

Active Member
Just got my 6 weeks labs back after switching to Defy for HCG.
Initial labs at consult were:
Total T 1117 ng/dl range 264-916
Free T 29.7 pg/ml range 7.2-24.0
Estradiol sens 45.3pg/ml range 8.0-35
Shbg 46.2 nmol/l range 19.3-76.4
DHEA-s 116 ug/dl range 71.6-375.4
Progesterone .4g/dL range 0-.5

After adding DHEA 25mg daily, HCG 500 iu E3.5d, anastrozole .125 E3.5d, lowering my T dose to 40mg E3.5d from 50mg my results now are:
Total T 863
Free T 33.7
Estradiol 24.4
DHEA 468.2
Shbg 38.0
Progesterone .4

The obvious I need to lower the daily dose of DHEA. Larger question is Total testosterone to Free ratio. If you go by labcorp standards I am 33pg/ml. If I evaluate based on SHBG and Albumin through the calculator it is closer to 19pg/ml. What are your thoughts on proper method to evaluate free T? My doc that manages my Hemotology covers my T prescription to allow insurance reimbursement. He gets a little cautious when I am over top of range, but I feel better closer to 1000 total T. Thoughts?
 
Is your doctor aware that it was just last summer that LabCorp adjusted their ranges? That means that an awful lot of men woke up one morning and were posting out-of-range total testosterone values. The only change? LabCorp arbitrarily fiddling with their internal ranges. I raise this to point out that it makes little sense for him to react so negatively to something that has no clinical implications. Numbers/lab values in this game are certainly important, but to lock-step every patient into a range (without understanding the politics behind the range) is foolish. Feel good closer to 1000? I'd argue to stay there.
 
Thanks for the input. I may just take my whole regimen thru Defy. Will Cost a little more out of pocket, but don’t have to be the one continuously trying to educate the doc!
 
Thanks for the input. I may just take my whole regimen thru Defy. Will Cost a little more out of pocket, but don't have to be the one continuously trying to educate the doc!

How much is peace of mind worth? Not being snide, I fully understand that costs have to be managed, but don't complicate your life if you can avoid it. It may be reasonable to have that discussion with your doctor once...but again and again...you start to dread the whole interaction.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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